{"id":"https://openalex.org/W4362486802","doi":"https://doi.org/10.1158/1940-6207.c.6543562","title":"Data from Long-term Epigenetic Therapy with Oral Zebularine Has Minimal Side Effects and Prevents Intestinal Tumors in Mice","display_name":"Data from Long-term Epigenetic Therapy with Oral Zebularine Has Minimal Side Effects and Prevents Intestinal Tumors in Mice","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362486802","doi":"https://doi.org/10.1158/1940-6207.c.6543562"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.c.6543562","doi":"https://doi.org/10.1158/1940-6207.c.6543562","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6543562","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1940-6207.c.6543562","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014163530","display_name":"Christine B. Yoo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine B. Yoo","raw_affiliation_strings":["Biochemistry and Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069757285","display_name":"Jody C. Chuang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jody C. Chuang","raw_affiliation_strings":["Biochemistry and Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044303659","display_name":"Hyang\u2010Min Byun","orcid":"https://orcid.org/0000-0002-6278-3165","observed_orcids":["https://orcid.org/0000-0002-6278-3165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyang-Min Byun","raw_affiliation_strings":["Hematology, and","Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, and","institution_ids":[]},{"raw_affiliation_string":"Pathology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072260744","display_name":"Gerda Egger","orcid":"https://orcid.org/0000-0003-2489-155X","observed_orcids":["https://orcid.org/0000-0003-2489-155X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerda Egger","raw_affiliation_strings":["USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112485671","display_name":"Allen S. Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen S. Yang","raw_affiliation_strings":["Hematology, and","USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, and","institution_ids":[]},{"raw_affiliation_string":"USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001173511","display_name":"Louis Dubeau","orcid":"https://orcid.org/0000-0001-6736-4907","observed_orcids":["https://orcid.org/0000-0001-6736-4907"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis Dubeau","raw_affiliation_strings":["Pathology, and","USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, and","institution_ids":[]},{"raw_affiliation_string":"USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113752836","display_name":"Tiffany I. Long","orcid":"https://orcid.org/0000-0002-6713-6717","observed_orcids":["https://orcid.org/0000-0002-6713-6717"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffany Long","raw_affiliation_strings":["Surgery,","USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery,","institution_ids":[]},{"raw_affiliation_string":"USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025761663","display_name":"Peter W. Laird","orcid":"https://orcid.org/0000-0001-9117-3641","observed_orcids":["https://orcid.org/0000-0001-9117-3641"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W. Laird","raw_affiliation_strings":["Biochemistry and Molecular Biology,","Surgery,","USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology,","institution_ids":[]},{"raw_affiliation_string":"Surgery,","institution_ids":[]},{"raw_affiliation_string":"USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102108516","display_name":"V\u00edctor E. M\u00e1rquez","orcid":"https://orcid.org/0009-0007-9619-8531","observed_orcids":["https://orcid.org/0009-0007-9619-8531"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor E. Marquez","raw_affiliation_strings":["Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088347458","display_name":"Peter A. Jones","orcid":"https://orcid.org/0000-0001-8309-4767","observed_orcids":["https://orcid.org/0000-0001-8309-4767"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter A. Jones","raw_affiliation_strings":["Biochemistry and Molecular Biology,","USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;","Urology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology,","institution_ids":[]},{"raw_affiliation_string":"USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Urology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5088347458"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zebularine","display_name":"zebularine","score":1.0},{"id":"https://openalex.org/keywords/dna-methylation-inhibitors","display_name":"DNA methylation inhibitors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.9150000214576721},{"id":"https://openalex.org/keywords/apcmin-mice","display_name":"ApcMin/+ mice","score":0.9160000085830688},{"id":"https://openalex.org/keywords/intestinal-neoplasms","display_name":"intestinal tumors","score":0.6380000114440918},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.49799999594688416},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5429999828338623},{"id":"https://openalex.org/keywords/aldehyde-oxidase","display_name":"aldehyde oxidase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/polyp-prevention","display_name":"polyp prevention","score":0.5},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.708324670791626},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5766251087188721},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5184311866760254},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5164235234260559},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5085445642471313},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4808395802974701},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4655393362045288},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.41345149278640747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3428957462310791},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3363025486469269},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2675490379333496},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.21976009011268616},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19322961568832397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08771371841430664}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1940-6207.c.6543562","doi":"https://doi.org/10.1158/1940-6207.c.6543562","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6543562","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1940-6207.c.6543562.v1","doi":"https://doi.org/10.1158/1940-6207.c.6543562.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1940-6207.c.6543562.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1940-6207.c.6543562","doi":"https://doi.org/10.1158/1940-6207.c.6543562","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6543562","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W219347884","https://openalex.org/W1504303645","https://openalex.org/W1785331055","https://openalex.org/W1983293961","https://openalex.org/W1990381590","https://openalex.org/W1990606472","https://openalex.org/W1995023151","https://openalex.org/W1995913255","https://openalex.org/W1998894350","https://openalex.org/W2001258296","https://openalex.org/W2002822143","https://openalex.org/W2015248217","https://openalex.org/W2017583063","https://openalex.org/W2021069666","https://openalex.org/W2023972136","https://openalex.org/W2027124686","https://openalex.org/W2031129569","https://openalex.org/W2038437697","https://openalex.org/W2040149948","https://openalex.org/W2057830803","https://openalex.org/W2061578142","https://openalex.org/W2062093164","https://openalex.org/W2066602623","https://openalex.org/W2076754933","https://openalex.org/W2083535257","https://openalex.org/W2093404230","https://openalex.org/W2100128545","https://openalex.org/W2106401558","https://openalex.org/W2109890006","https://openalex.org/W2111041465","https://openalex.org/W2118666253","https://openalex.org/W2121417064","https://openalex.org/W2122580718","https://openalex.org/W2129863070","https://openalex.org/W2129867437","https://openalex.org/W2133600149","https://openalex.org/W2138302361","https://openalex.org/W2142643115","https://openalex.org/W2146745114","https://openalex.org/W2149260648","https://openalex.org/W2155577690","https://openalex.org/W2155725346","https://openalex.org/W2785915477","https://openalex.org/W4240907666"],"related_works":["https://openalex.org/W2105116198","https://openalex.org/W4362486884","https://openalex.org/W2380573693","https://openalex.org/W2272904685","https://openalex.org/W1983293961","https://openalex.org/W3204531380","https://openalex.org/W7100881468","https://openalex.org/W2589054828","https://openalex.org/W4362477829","https://openalex.org/W2158950810"],"abstract_inverted_index":{"Abstract":[0],"Recent":[1],"successes":[2],"in":[3,43,68,77,89,100,136,171,179,194,242],"the":[4,10,19,38,49,52,78,101,109,123,132,147,188,211],"application":[5],"of":[6,12,21,24,51,83,104,114,118,131,150,160,169,177,202,218,224,236],"epigenetic":[7,239],"drugs":[8,240],"for":[9,210],"treatment":[11,235],"myelodysplastic":[13],"syndrome":[14],"have":[15],"raised":[16],"questions":[17],"on":[18,54],"safety":[20],"long-term":[22,215],"administration":[23,168,217],"DNA":[25,39,69,231],"methylation":[26,40,70],"inhibitors.":[27],"We":[28,139],"treated":[29],"preweaned":[30],"cancer":[31,61],"prone":[32],"ApcMin/+":[33],"(Min)":[34],"mice":[35,86,105,237],"continuously":[36],"with":[37,165,238],"inhibitor":[41],"zebularine":[42,170,219],"their":[44,137],"drinking":[45],"water":[46],"to":[47,129,185,199],"determine":[48],"effects":[50],"drug":[53],"normal":[55],"mouse":[56],"development":[57],"as":[58,60],"well":[59],"prevention.":[62],"Zebularine":[63],"caused":[64],"a":[65,221,229],"tissue-specific":[66,230],"reduction":[67],"at":[71],"B1":[72],"short":[73],"interspersed":[74],"nucleotide":[75],"elements":[76],"small":[79],"and":[80,144,152,246],"large":[81],"intestines":[82],"female":[84],"Min":[85,172,180,195],"but":[87],"not":[88,141],"other":[90],"organs":[91],"examined":[92],"after":[93],"chronic":[94,166],"oral":[95,167,216],"treatment.":[96,110],"No":[97],"significant":[98],"difference":[99],"average":[102,175,189],"weights":[103],"was":[106],"observed":[107],"during":[108],"In":[111],"addition,":[112],"analysis":[113,149],"global":[115],"gene":[116],"expression":[117],"colonic":[119],"epithelial":[120],"cells":[121],"from":[122,146,183],"females":[124,181],"indicated":[125],"that":[126,214],"only":[127,243],"3%":[128],"6%":[130],"genes":[133],"were":[134],"affected":[135],"expression.":[138],"did":[140],"detect":[142],"toxicity":[143],"abnormalities":[145],"histopathologic":[148],"liver":[151],"intestinal":[153,225],"tissues.":[154],"Lastly,":[155],"we":[156],"tested":[157],"whether":[158],"prevention":[159],"tumorigenesis":[161],"can":[162],"be":[163],"achieved":[164],"mice.":[173],"The":[174],"number":[176,191],"polyps":[178],"decreased":[182],"58":[184],"1,":[186],"whereas":[187],"polyp":[190],"remained":[192],"unaffected":[193],"males":[196],"possibly":[197],"due":[198],"differential":[200],"activity":[201],"aldehyde":[203],"oxidase.":[204],"Taken":[205],"together,":[206],"our":[207],"results":[208],"show":[209],"first":[212],"time":[213],"causes":[220],"gender-specific":[222],"abrogation":[223],"tumors":[226],"while":[227],"causing":[228],"demethylation.":[232],"Importantly,":[233],"prolonged":[234],"resulted":[241],"minor":[244],"developmental":[245],"histologic":[247],"changes.":[248]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
