{"id":"https://openalex.org/W4362486767","doi":"https://doi.org/10.1158/1940-6207.22523035","title":"Perspective from Long-term Epigenetic Therapy with Oral Zebularine Has Minimal Side Effects and Prevents Intestinal Tumors in Mice","display_name":"Perspective from Long-term Epigenetic Therapy with Oral Zebularine Has Minimal Side Effects and Prevents Intestinal Tumors in Mice","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362486767","doi":"https://doi.org/10.1158/1940-6207.22523035"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.22523035","doi":"https://doi.org/10.1158/1940-6207.22523035","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.22523035","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1940-6207.22523035","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014163530","display_name":"Christine B. Yoo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine B. Yoo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069757285","display_name":"Jody C. Chuang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jody C. Chuang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044303659","display_name":"Hyang\u2010Min Byun","orcid":"https://orcid.org/0000-0002-6278-3165","observed_orcids":["https://orcid.org/0000-0002-6278-3165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyang-Min Byun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072260744","display_name":"Gerda Egger","orcid":"https://orcid.org/0000-0003-2489-155X","observed_orcids":["https://orcid.org/0000-0003-2489-155X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerda Egger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112485671","display_name":"Allen S. Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allen S. Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001173511","display_name":"Louis Dubeau","orcid":"https://orcid.org/0000-0001-6736-4907","observed_orcids":["https://orcid.org/0000-0001-6736-4907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louis Dubeau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113752836","display_name":"Tiffany I. Long","orcid":"https://orcid.org/0000-0002-6713-6717","observed_orcids":["https://orcid.org/0000-0002-6713-6717"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tiffany Long","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025761663","display_name":"Peter W. Laird","orcid":"https://orcid.org/0000-0001-9117-3641","observed_orcids":["https://orcid.org/0000-0001-9117-3641"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter W. Laird","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102108516","display_name":"V\u00edctor E. M\u00e1rquez","orcid":"https://orcid.org/0009-0007-9619-8531","observed_orcids":["https://orcid.org/0009-0007-9619-8531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor E. Marquez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088347458","display_name":"Peter A. Jones","orcid":"https://orcid.org/0000-0001-8309-4767","observed_orcids":["https://orcid.org/0000-0001-8309-4767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter A. Jones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zebularine","display_name":"zebularine","score":0.996999979019165},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.7239999771118164},{"id":"https://openalex.org/keywords/long-term-treatment","display_name":"long-term treatment","score":0.7419999837875366},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.828000009059906},{"id":"https://openalex.org/keywords/intestinal-neoplasms","display_name":"intestinal tumors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/colorectal-cancer-prevention","display_name":"colorectal cancer prevention","score":0.7559999823570251},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.7409999966621399},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.7073196172714233},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6330525875091553},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.5646733641624451},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42476707696914673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40959805250167847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27352720499038696},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13434043526649475},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12392324209213257},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06997013092041016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1940-6207.22523035","doi":"https://doi.org/10.1158/1940-6207.22523035","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.22523035","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1940-6207.22523035.v1","doi":"https://doi.org/10.1158/1940-6207.22523035.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.22523035.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22523035","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Perspective_from_Long-term_Epigenetic_Therapy_with_Oral_Zebularine_Has_Minimal_Side_Effects_and_Prevents_Intestinal_Tumors_in_Mice/22523035","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1158/1940-6207.22523035","doi":"https://doi.org/10.1158/1940-6207.22523035","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.22523035","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2380573693","https://openalex.org/W4362486891","https://openalex.org/W2105116198","https://openalex.org/W2272904685","https://openalex.org/W2316328071","https://openalex.org/W2338850359","https://openalex.org/W3025893080","https://openalex.org/W4283016031","https://openalex.org/W2944667154","https://openalex.org/W2042685234"],"abstract_inverted_index":{"Perspective":[0],"from":[1],"Long-term":[2],"Epigenetic":[3],"Therapy":[4],"with":[5],"Oral":[6],"Zebularine":[7],"Has":[8],"Minimal":[9],"Side":[10],"Effects":[11],"and":[12],"Prevents":[13],"Intestinal":[14],"Tumors":[15],"in":[16],"Mice":[17]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}