{"id":"https://openalex.org/W4362484786","doi":"https://doi.org/10.1158/1535-7163.22507564","title":"Supplemental Figures 1-6 and Supplemental Tables 1-3 from NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer","display_name":"Supplemental Figures 1-6 and Supplemental Tables 1-3 from NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362484786","doi":"https://doi.org/10.1158/1535-7163.22507564"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22507564","doi":"https://doi.org/10.1158/1535-7163.22507564","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22507564","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.22507564","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041704230","display_name":"Long-Shan Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Long-Shan Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Srilakshmi Reddy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srilakshmi Reddy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101690704","display_name":"Zhenhua Lin","orcid":"https://orcid.org/0000-0002-5633-2907","observed_orcids":["https://orcid.org/0000-0002-5633-2907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhen-Hua Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039815644","display_name":"Shuangping Liu","orcid":"https://orcid.org/0000-0001-6029-3245","observed_orcids":["https://orcid.org/0000-0001-6029-3245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuangping Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023786506","display_name":"Hyunsil Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyunsil Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012745900","display_name":"Stephen G. Chun","orcid":"https://orcid.org/0000-0002-4324-8044","observed_orcids":["https://orcid.org/0000-0002-4324-8044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen G. Chun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105789795","display_name":"William G. Bornmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William G. Bornmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074139393","display_name":"Joel D. Thibodeaux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel Thibodeaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045838","display_name":"Jingsheng Yan","orcid":"https://orcid.org/0000-0002-3856-8019","observed_orcids":["https://orcid.org/0000-0002-3856-8019"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingsheng Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085285744","display_name":"Gaurab Chakrabarti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaurab Chakrabarti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101198644","display_name":"Xian-Jin Xie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xian-Jin Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000204424","display_name":"Baran D. Sumer","orcid":"https://orcid.org/0000-0002-8371-4388","observed_orcids":["https://orcid.org/0000-0002-8371-4388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baran D. Sumer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016606481","display_name":"David A. Boothman","orcid":"https://orcid.org/0000-0001-7474-9020","observed_orcids":["https://orcid.org/0000-0001-7474-9020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Boothman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068474532","display_name":"John S. Yordy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John S. Yordy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":1.0},{"id":"https://openalex.org/keywords/beta-lapachone","display_name":"\u03b2-lapachone","score":0.7540000081062317},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/nad-depletion","display_name":"NAD+ depletion","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9620000123977661},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.6800000071525574},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.7900000214576721},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6660000085830688},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.765999972820282},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6947472095489502},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.6312529444694519},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5473617911338806},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5421186089515686},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.5134209394454956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4786590039730072},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46502116322517395},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41312727332115173},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3664274215698242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3395159840583801},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3268964886665344},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.2586901783943176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22724536061286926},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1652105450630188},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12147775292396545},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10564115643501282}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22507564","doi":"https://doi.org/10.1158/1535-7163.22507564","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22507564","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22507564.v1","doi":"https://doi.org/10.1158/1535-7163.22507564.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22507564.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39969097","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22507564","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplemental_Figures_1-6_and_Supplemental_Tables_1-3_from_NQO1-Mediated_Tumor-Selective_Lethality_and_Radiosensitization_for_Head_and_Neck_Cancer/22507564","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22507564","doi":"https://doi.org/10.1158/1535-7163.22507564","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22507564","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362484786.pdf","grobid_xml":"https://content.openalex.org/works/W4362484786.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362493739","https://openalex.org/W2336123209","https://openalex.org/W2321986047","https://openalex.org/W1974742690","https://openalex.org/W2909437688","https://openalex.org/W4361955132","https://openalex.org/W2026604822","https://openalex.org/W2147495392","https://openalex.org/W1140549219","https://openalex.org/W3006113063"],"abstract_inverted_index":{"Supplemental":[0,18,28,39,56,89,109,122],"Figure":[1,19,29,40,57,74],"1.":[2,91],"Elevated":[3],"NQO1":[4,32,52,92,136],"expression":[5],"in":[6,85,99,119],"patients":[7],"with":[8,11],"HNC":[9,71,86,101,120],"correlates":[10],"poor":[12],"overall":[13],"survival":[14],"to":[15,69,116],"standard":[16],"therapy;":[17],"2.":[20,111],"Functional":[21],"shRNA-NQO1":[22],"knockdown":[23],"rescues":[24],"\u03b2-lapinduced":[25],"cell":[26,102],"death;":[27],"3.":[30,124],"\u03b2-Lap-induced":[31],"dependent":[33,53],"DNA":[34],"damage":[35],"and":[36,47,67,83,95,104,132,137],"NAD+":[37],"depletion;":[38],"4.":[41],"Combination":[42],"sublethal":[43],"doses":[44,113],"of":[45,65,77,81,97],"\u03b2-lap":[46,68,82],"low":[48],"dose":[49],"IR":[50,66,84],"induce":[51],"anti-cancer":[54],"lethality;":[55],"5.":[58],"Cooperative":[59],"antitumor":[60],"efficacy":[61],"using":[62],"a":[63],"combination":[64,80],"treat":[70],"xenograft":[72,87],"models;":[73,88],"6.":[75],"Expression":[76],"Ki-67":[78],"after":[79],"Table":[90,110,123],"enzyme":[93],"activity":[94,98],"abrogation":[96],"41":[100],"lines":[103],"primary":[105],"human":[106],"IMR90":[107],"fibroblasts;":[108],"Equitoxic":[112],"comparing":[114],"single":[115],"combined":[117],"treatment":[118],"cells;":[121],"Individual":[125],"patient":[126],"gender,":[127],"age,":[128],"subsite,":[129],"stage,":[130],"histology":[131],"IHC":[133],"scoring":[134],"for":[135],"Catalase":[138]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}