{"id":"https://openalex.org/W4362484094","doi":"https://doi.org/10.1158/1541-7786.c.6545627","title":"Data from Uveal Melanoma Exosomes Induce a Prometastatic Microenvironment through Macrophage Migration Inhibitory Factor","display_name":"Data from Uveal Melanoma Exosomes Induce a Prometastatic Microenvironment through Macrophage Migration Inhibitory Factor","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362484094","doi":"https://doi.org/10.1158/1541-7786.c.6545627"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6545627","doi":"https://doi.org/10.1158/1541-7786.c.6545627","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6545627","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.c.6545627","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026962347","display_name":"Grazia Ambrosini","orcid":"https://orcid.org/0000-0002-3051-362X","observed_orcids":["https://orcid.org/0000-0002-3051-362X"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grazia Ambrosini","raw_affiliation_strings":["The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St. Nicholas Avenue, New York, NY 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St. Nicholas Avenue, New York, NY 10032","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010597464","display_name":"Alex J. Rai","orcid":"https://orcid.org/0000-0002-3734-4590","observed_orcids":["https://orcid.org/0000-0002-3734-4590"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex J. Rai","raw_affiliation_strings":["The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St. Nicholas Avenue, New York, NY 10032"],"raw_orcid":"https://orcid.org/0000-0002-3734-4590","affiliations":[{"raw_affiliation_string":"The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St. Nicholas Avenue, New York, NY 10032","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086473468","display_name":"Richard D. Carvajal","orcid":"https://orcid.org/0000-0002-3796-1118","observed_orcids":["https://orcid.org/0000-0002-3796-1118"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Carvajal","raw_affiliation_strings":["The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St. Nicholas Avenue, New York, NY 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St. Nicholas Avenue, New York, NY 10032","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006913373","display_name":"Gary K. Schwartz","orcid":"https://orcid.org/0000-0003-1813-5061","observed_orcids":["https://orcid.org/0000-0003-1813-5061"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary K. Schwartz","raw_affiliation_strings":["The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St. Nicholas Avenue, New York, NY 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St. Nicholas Avenue, New York, NY 10032","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":1.0},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9089999794960022},{"id":"https://openalex.org/keywords/macrophage-migration-inhibitory-factor","display_name":"macrophage migration inhibitory factor","score":0.9169999957084656},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hepatocyte-activation","display_name":"hepatocyte activation","score":0.5609999895095825},{"id":"https://openalex.org/keywords/exosomal-proteome","display_name":"exosomal proteome","score":0.5509999990463257},{"id":"https://openalex.org/keywords/metastatic-markers","display_name":"metastatic markers","score":0.5519999861717224},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6880000233650208},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.7540000081062317},{"id":"https://openalex.org/keywords/metastasis-prevention","display_name":"metastasis prevention","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C104177226","wikidata":"https://www.wikidata.org/wiki/Q15311903","display_name":"Macrophage migration inhibitory factor","level":3,"score":0.8648484349250793},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8440892696380615},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.7531934976577759},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.7446450591087341},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7097318172454834},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6607581377029419},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.58614581823349},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.48222529888153076},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.475673109292984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3922986388206482},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3848347067832947},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37545686960220337},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36021625995635986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34820085763931274},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31366032361984253},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.19548338651657104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18165358901023865},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.14048483967781067},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.c.6545627","doi":"https://doi.org/10.1158/1541-7786.c.6545627","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6545627","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6545627","doi":"https://doi.org/10.1158/1541-7786.c.6545627","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6545627","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W630263923","https://openalex.org/W1533729577","https://openalex.org/W1601681275","https://openalex.org/W1779367761","https://openalex.org/W1939970239","https://openalex.org/W1950118853","https://openalex.org/W1965035416","https://openalex.org/W2003474477","https://openalex.org/W2008264147","https://openalex.org/W2027848378","https://openalex.org/W2046933020","https://openalex.org/W2048951066","https://openalex.org/W2052211053","https://openalex.org/W2061597055","https://openalex.org/W2074701159","https://openalex.org/W2087448306","https://openalex.org/W2099293633","https://openalex.org/W2111778115","https://openalex.org/W2136802909","https://openalex.org/W2143878396","https://openalex.org/W2163037808","https://openalex.org/W2169491358","https://openalex.org/W2190836196","https://openalex.org/W2265419075","https://openalex.org/W2310474609","https://openalex.org/W2321395476","https://openalex.org/W2333728922","https://openalex.org/W2408787182","https://openalex.org/W2416973816","https://openalex.org/W2468768867","https://openalex.org/W2516337088","https://openalex.org/W2566408036","https://openalex.org/W2570946556","https://openalex.org/W2617277129","https://openalex.org/W2790701366","https://openalex.org/W2791527635","https://openalex.org/W2918972495","https://openalex.org/W2938965256","https://openalex.org/W2943261504","https://openalex.org/W2946962120","https://openalex.org/W2952257329","https://openalex.org/W3045930758","https://openalex.org/W3091384409","https://openalex.org/W3091819807","https://openalex.org/W3120388036"],"related_works":["https://openalex.org/W4205823171","https://openalex.org/W4401912596","https://openalex.org/W3083088789","https://openalex.org/W3175799242","https://openalex.org/W3091819807","https://openalex.org/W3177681408","https://openalex.org/W4311039790","https://openalex.org/W2752156067","https://openalex.org/W2118088184","https://openalex.org/W7043437331"],"abstract_inverted_index":{"Abstract":[0],"Uveal":[1],"melanoma":[2,6,46,77,92,121],"is":[3,55],"a":[4,128,151,186,213],"rare":[5],"subtype":[7],"different":[8],"from":[9,108],"cutaneous":[10],"melanoma,":[11],"with":[12,85,165],"high":[13],"incidence":[14],"of":[15,44,66,75,83,96,103,119,172,182],"liver":[16,112],"metastasis":[17,183,220],"and":[18,31,38,49,60,79,100,105,157,168],"poor":[19],"prognosis.":[20],"Cancer":[21],"cell\u2013derived":[22],"extracellular":[23],"vesicles":[24],"have":[25,127],"been":[26],"shown":[27],"to":[28,57,191,218],"induce":[29,94,117],"proinflammatory":[30,143],"prometastatic":[32],"signaling":[33,98],"in":[34,52,62,115,131,154,163,174,178,195,204,221],"the":[35,63,72,81,101,125,132,142,170,179,202],"tumor":[36],"microenvironment":[37],"at":[39],"distant":[40],"sites.":[41],"The":[42],"characterization":[43],"uveal":[45,76,91,120,196,222],"exosome":[47],"cargo":[48],"its":[50,158],"role":[51,130],"metastatic":[53,67,86,193],"spread":[54,194],"essential":[56],"identify":[58],"targets":[59],"intervene":[61],"early":[64,180],"stages":[65,181],"development.":[68],"Our":[69],"study":[70,200],"characterizes":[71],"proteomic":[73],"content":[74],"exosomes":[78,93,126],"identified":[80],"presence":[82],"markers":[84],"properties.":[87],"We":[88,139],"demonstrated":[89],"that":[90,124,141,207],"activation":[95],"cell":[97,137,161],"pathways":[99],"release":[102],"cytokines":[104],"growth":[106],"factors":[107],"hepatocytes.":[109],"These":[110],"exosome-stimulated":[111,166],"cells":[113],"could":[114],"turn":[116],"migration":[118,146,162],"cells,":[122],"confirming":[123],"functional":[129],"cross-talk":[133],"between":[134],"these":[135,155],"two":[136],"types.":[138],"found":[140],"cytokine":[144],"macrophage":[145],"inhibitory":[147],"factor":[148],"(MIF)":[149],"was":[150],"major":[152],"player":[153],"mechanisms":[156],"blockade":[159],"inhibited":[160],"coculture":[164],"hepatocytes":[167],"prevented":[169],"development":[171],"metastases":[173],"vivo.":[175],"Targeting":[176],"MIF":[177,208],"may":[184,210],"represent":[185],"novel":[187,214],"adjuvant":[188,215],"drug":[189,216],"therapy":[190,217],"prevent":[192,219],"melanoma.":[197,223],"Implications:":[198],"This":[199],"provides":[201],"first":[203],"vivo":[205],"evidence":[206],"inhibition":[209],"serve":[211],"as":[212]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-04-05T00:00:00"}
