{"id":"https://openalex.org/W4362483541","doi":"https://doi.org/10.1158/2159-8290.22528455","title":"Supplementary Figure S6 from Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2","display_name":"Supplementary Figure S6 from Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362483541","doi":"https://doi.org/10.1158/2159-8290.22528455"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.22528455","doi":"https://doi.org/10.1158/2159-8290.22528455","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22528455","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/2159-8290.22528455","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086512281","display_name":"Michael P. O\u2019Connell","orcid":"https://orcid.org/0000-0002-8615-7660","observed_orcids":["https://orcid.org/0000-0002-8615-7660"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael P. O'Connell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006710874","display_name":"Katie Marchbank","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katie Marchbank","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005085527","display_name":"Marie R. Webster","orcid":"https://orcid.org/0000-0001-7633-7150","observed_orcids":["https://orcid.org/0000-0001-7633-7150"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie R. Webster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030585540","display_name":"Alexander A. Valiga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander A. Valiga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Amanpreet Kaur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanpreet Kaur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091555027","display_name":"Adina Vultur","orcid":"https://orcid.org/0000-0003-0068-9496","observed_orcids":["https://orcid.org/0000-0003-0068-9496"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adina Vultur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435369","display_name":"Ling Li","orcid":"https://orcid.org/0000-0003-1847-4522","observed_orcids":["https://orcid.org/0000-0003-1847-4522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028792712","display_name":"Meenhard Herlyn","orcid":"https://orcid.org/0000-0003-0839-0739","observed_orcids":["https://orcid.org/0000-0003-0839-0739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meenhard Herlyn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090236197","display_name":"Jessie Villanueva","orcid":"https://orcid.org/0000-0001-5701-2609","observed_orcids":["https://orcid.org/0000-0001-5701-2609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessie Villanueva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432490","display_name":"Qin Liu","orcid":"https://orcid.org/0000-0001-9964-580X","observed_orcids":["https://orcid.org/0000-0001-9964-580X","https://orcid.org/0009-0000-3931-0813"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qin Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103978106","display_name":"Xiangfan Yin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiangfan Yin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058649466","display_name":"Sandy Widura","orcid":"https://orcid.org/0009-0005-7424-9356","observed_orcids":["https://orcid.org/0009-0005-7424-9356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandy Widura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030076503","display_name":"Janelle Nelson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janelle Nelson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010167165","display_name":"Nivia Ruiz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nivia Ruiz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066672954","display_name":"Tura C. Camilli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tura C. Camilli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055023038","display_name":"Fred Eliezer Indig","orcid":"https://orcid.org/0000-0002-7106-8278","observed_orcids":["https://orcid.org/0000-0002-7106-8278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fred E. Indig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023174631","display_name":"Keith T. Flaherty","orcid":"https://orcid.org/0000-0002-3402-0478","observed_orcids":["https://orcid.org/0000-0002-3402-0478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith T. Flaherty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035427219","display_name":"Jennifer Ann Wargo","orcid":"https://orcid.org/0000-0003-3438-7576","observed_orcids":["https://orcid.org/0000-0003-3438-7576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer A. Wargo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047185974","display_name":"Dennie Tompers Frederick","orcid":"https://orcid.org/0000-0003-3355-5267","observed_orcids":["https://orcid.org/0000-0003-3355-5267"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennie T. Frederick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071770314","display_name":"Zachary Aaron Cooper","orcid":"https://orcid.org/0000-0003-1059-0940","observed_orcids":["https://orcid.org/0000-0003-1059-0940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zachary A. Cooper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Suresh Nair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suresh Nair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009482043","display_name":"Ravi K. Amaravadi","orcid":"https://orcid.org/0000-0002-5768-2474","observed_orcids":["https://orcid.org/0000-0002-5768-2474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ravi K. Amaravadi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012671311","display_name":"Lynn Mara Schuchter","orcid":"https://orcid.org/0000-0002-0523-4346","observed_orcids":["https://orcid.org/0000-0002-0523-4346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lynn M. Schuchter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035929126","display_name":"Giorgos Constantine Karakousis","orcid":"https://orcid.org/0000-0002-9321-2795","observed_orcids":["https://orcid.org/0000-0002-9321-2795"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgos C. Karakousis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115592426","display_name":"Wei Xu","orcid":"https://orcid.org/0009-0006-3042-608X","observed_orcids":["https://orcid.org/0009-0006-3042-608X","https://orcid.org/0000-0001-9341-8382","https://orcid.org/0009-0000-3819-4152","https://orcid.org/0000-0002-3265-7475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110634","display_name":"Xiaowei Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaowei Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085589424","display_name":"Ashani T. Weeraratna","orcid":"https://orcid.org/0000-0003-0448-6952","observed_orcids":["https://orcid.org/0000-0003-0448-6952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashani T. Weeraratna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8899999856948853},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/phenotypic-plasticity","display_name":"phenotypic plasticity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ror1","display_name":"ROR1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ror2","display_name":"ROR2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/braf-inhibitors","display_name":"BRAF inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cancer-cell-sensitivity","display_name":"tumor cell sensitivity","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C23440912","wikidata":"https://www.wikidata.org/wiki/Q18030230","display_name":"ROR1","level":5,"score":0.6504761576652527},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.557987630367279},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.503454864025116},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.47785326838493347},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4668228030204773},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4329533576965332},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4172079563140869},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40560048818588257},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.402137815952301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.334263414144516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33289384841918945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3109593391418457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2662835121154785},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.22445443272590637},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20943480730056763},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2093651294708252},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.06108418107032776},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.059346526861190796},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2159-8290.22528455","doi":"https://doi.org/10.1158/2159-8290.22528455","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22528455","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.22528455","doi":"https://doi.org/10.1158/2159-8290.22528455","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22528455","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4285190535","https://openalex.org/W2610403267","https://openalex.org/W2150814991","https://openalex.org/W2160930114","https://openalex.org/W2027911638","https://openalex.org/W3029761319","https://openalex.org/W284991352","https://openalex.org/W2029323837","https://openalex.org/W56039399","https://openalex.org/W1977408386"],"abstract_inverted_index":{"PDF":[0],"file":[1],"165K,":[2],"Decreases":[3],"in":[4],"ROR2":[5],"expression":[6],"increase":[7],"tumor":[8],"cell":[9],"sensitivity":[10],"to":[11],"BRAF":[12],"inhibitors":[13]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}