{"id":"https://openalex.org/W4362483005","doi":"https://doi.org/10.22146/jfps.5485","title":"Potential Activity of Caryophyllene Derivatives as Xanthine Oxidase Inhibitor: An in silico Quantitative Structure-Activity Relationship Analysis","display_name":"Potential Activity of Caryophyllene Derivatives as Xanthine Oxidase Inhibitor: An in silico Quantitative Structure-Activity Relationship Analysis","publication_year":2022,"publication_date":"2022-12-31","ids":{"openalex":"https://openalex.org/W4362483005","doi":"https://doi.org/10.22146/jfps.5485"},"language":"en","primary_location":{"id":"doi:10.22146/jfps.5485","doi":"https://doi.org/10.22146/jfps.5485","is_oa":true,"landing_page_url":"https://doi.org/10.22146/jfps.5485","pdf_url":"https://jurnal.ugm.ac.id/v3/JFPS/article/download/5485/2234","source":{"id":"https://openalex.org/S2738601923","display_name":"Journal of Food and Pharmaceutical Sciences","issn_l":"2089-7200","issn":["2089-7200","2339-0948"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food and Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jurnal.ugm.ac.id/v3/JFPS/article/download/5485/2234","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011966868","display_name":"Arif Setiawansyah","orcid":"https://orcid.org/0000-0002-1443-8666","observed_orcids":["https://orcid.org/0000-0002-1443-8666"]},"institutions":[{"id":"https://openalex.org/I4210163351","display_name":"Universitas Kader Bangsa","ror":"https://ror.org/05f06q946","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210163351"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Arif Setiawansyah","raw_affiliation_strings":["Fakultas Farmasi, Universitas Kader Bangsa, Palembang, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-1443-8666","affiliations":[{"raw_affiliation_string":"Fakultas Farmasi, Universitas Kader Bangsa, Palembang, Indonesia","institution_ids":["https://openalex.org/I4210163351"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078060664","display_name":"Baiq Maylinda Gemantari","orcid":"https://orcid.org/0000-0001-5401-9784","observed_orcids":["https://orcid.org/0000-0001-5401-9784"]},"institutions":[{"id":"https://openalex.org/I4405258964","display_name":"Universitas Hamzanwadi","ror":"https://ror.org/01g3c3365","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405258964"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Baiq Maylinda Gemantari","raw_affiliation_strings":["Faculty of Health, Universitas Hamzanwadi, Selong, Nusa Tenggara Barat, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-5401-9784","affiliations":[{"raw_affiliation_string":"Faculty of Health, Universitas Hamzanwadi, Selong, Nusa Tenggara Barat, Indonesia","institution_ids":["https://openalex.org/I4405258964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4234,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.48099467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"700","last_page":"708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xanthine-oxidase-inhibition","display_name":"xanthine oxidase inhibition","score":0.9089999794960022},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.8270000219345093},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.7059999704360962},{"id":"https://openalex.org/keywords/caryophyllene-oxide","display_name":"caryophyllene oxide","score":0.8930000066757202},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.859000027179718},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8130000233650208},{"id":"https://openalex.org/keywords/lactone-ring","display_name":"lactone ring","score":0.753000020980835},{"id":"https://openalex.org/keywords/steric-hindrance","display_name":"steric hindrance","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.7766894102096558},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7186605334281921},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.515663743019104},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5033358931541443},{"id":"https://openalex.org/C2779470414","wikidata":"https://www.wikidata.org/wiki/Q50980","display_name":"Xanthine","level":3,"score":0.49525776505470276},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4918630123138428},{"id":"https://openalex.org/C2777820942","wikidata":"https://www.wikidata.org/wiki/Q8042974","display_name":"Xanthine oxidase inhibitor","level":4,"score":0.46943238377571106},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.40779992938041687},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.31374391913414},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3113231658935547},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.22146/jfps.5485","doi":"https://doi.org/10.22146/jfps.5485","is_oa":true,"landing_page_url":"https://doi.org/10.22146/jfps.5485","pdf_url":"https://jurnal.ugm.ac.id/v3/JFPS/article/download/5485/2234","source":{"id":"https://openalex.org/S2738601923","display_name":"Journal of Food and Pharmaceutical Sciences","issn_l":"2089-7200","issn":["2089-7200","2339-0948"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food and Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:8e45f386766b4ca9bd3e3ad8fe54f702","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8e45f386766b4ca9bd3e3ad8fe54f702","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Food and Pharmaceutical Sciences, Pp 700-708 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.22146/jfps.5485","doi":"https://doi.org/10.22146/jfps.5485","is_oa":true,"landing_page_url":"https://doi.org/10.22146/jfps.5485","pdf_url":"https://jurnal.ugm.ac.id/v3/JFPS/article/download/5485/2234","source":{"id":"https://openalex.org/S2738601923","display_name":"Journal of Food and Pharmaceutical Sciences","issn_l":"2089-7200","issn":["2089-7200","2339-0948"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food and Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329091","display_name":"Institut Teknologi Bandung","ror":"https://ror.org/00apj8t60"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362483005.pdf","grobid_xml":"https://content.openalex.org/works/W4362483005.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1487878063","https://openalex.org/W1994802835","https://openalex.org/W2045185413","https://openalex.org/W2058561421","https://openalex.org/W2066843609","https://openalex.org/W2105668062","https://openalex.org/W2132262459","https://openalex.org/W2751835111","https://openalex.org/W2753529925","https://openalex.org/W2769533173","https://openalex.org/W2801268472","https://openalex.org/W2976583878","https://openalex.org/W3035236982","https://openalex.org/W3049076550","https://openalex.org/W3093277047","https://openalex.org/W3119143490","https://openalex.org/W3119952098","https://openalex.org/W3148317443","https://openalex.org/W3200701719","https://openalex.org/W4214740847","https://openalex.org/W4250623703"],"related_works":["https://openalex.org/W4402829628","https://openalex.org/W4387158175","https://openalex.org/W2077310239","https://openalex.org/W2048067934","https://openalex.org/W2610714733","https://openalex.org/W4311860480","https://openalex.org/W3048843506","https://openalex.org/W2078673639","https://openalex.org/W4382404051","https://openalex.org/W2771490808"],"abstract_inverted_index":{"As":[0],"the":[1,5,28,38,59,65,75,94,106,110,113,119,122,142,151],"enzyme":[2,120],"responsible":[3],"for":[4,18],"uric":[6],"acid":[7],"formation,":[8],"Xanthine":[9,43,84],"oxidase":[10],"was":[11,23,55],"considered":[12],"to":[13,26,41,57,63,83,98,118,138,149],"be":[14],"a":[15,80],"therapeutic":[16],"target":[17,123],"hyperuricemic":[19],"treatment.":[20],"This":[21],"study":[22],"carried":[24],"out":[25],"assess":[27],"potential":[29],"of":[30,68,77,109,130,144,156],"caryophyllene,":[31],"and":[32,51,62,115,141],"its":[33],"derivates":[34,76],"usually":[35],"present":[36],"in":[37,125],"natural":[39],"product":[40],"inhibit":[42],"oxidase.":[44],"The":[45,71,128],"molecular":[46,60,116],"docking":[47],"using":[48],"Autodock":[49],"Tool":[50],"Biovia":[52],"Discovery":[53],"Studio":[54],"conducted":[56],"visualize":[58],"interaction":[61,117],"reveal":[64],"structure-activity":[66],"relationship":[67,102],"those":[69,89],"compounds.":[70],"results":[72],"showed":[73,79,104],"that":[74,105],"caryophyllene":[78,91,157],"higher":[81],"affinity":[82,114],"Oxide":[85],"than":[86],"Allopurinol.":[87],"Among":[88],"all,":[90],"oxide":[92,153],"has":[93],"most":[95],"stable":[96],"bonding":[97],"xanthine":[99,152],"oxide.":[100],"Structure-activity":[101],"analysis":[103],"chemical":[107],"properties":[108],"compound":[111],"affected":[112],"as":[121],"site":[124],"this":[126],"study.":[127],"number":[129],"double":[131],"bonds,":[132],"substituents":[133],"position,":[134],"conformational":[135],"structure":[136],"related":[137],"steric":[139],"hindrance,":[140],"presence":[143],"lactone":[145],"ring":[146],"were":[147],"assumed":[148],"influence":[150],"inhibitory":[154],"activity":[155],"derivates.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
