{"id":"https://openalex.org/W4362482500","doi":"https://doi.org/10.1158/1535-7163.22503643","title":"Supplemental Figure 3 from Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair Inhibitors","display_name":"Supplemental Figure 3 from Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair Inhibitors","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362482500","doi":"https://doi.org/10.1158/1535-7163.22503643"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22503643","doi":"https://doi.org/10.1158/1535-7163.22503643","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22503643","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplemental_Figure_3_from_Identification_of_Novel_Radiosensitizers_in_a_High-Throughput_Cell-Based_Screen_for_DSB_Repair_Inhibitors/22503643/1/files/39963097.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplemental_Figure_3_from_Identification_of_Novel_Radiosensitizers_in_a_High-Throughput_Cell-Based_Screen_for_DSB_Repair_Inhibitors/22503643/1/files/39963097.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049702760","display_name":"Alexander G. Goglia","orcid":"https://orcid.org/0000-0003-3970-2694","observed_orcids":["https://orcid.org/0000-0003-3970-2694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander G. Goglia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113092679","display_name":"Robert Delsite","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Delsite","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112471272","display_name":"Antonio N. Luz","orcid":"https://orcid.org/0009-0006-9966-2961","observed_orcids":["https://orcid.org/0009-0006-9966-2961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio N. Luz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040217547","display_name":"David Shahbazian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Shahbazian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054946644","display_name":"Ahmed F. Salem","orcid":"https://orcid.org/0009-0007-9640-5836","observed_orcids":["https://orcid.org/0009-0007-9640-5836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmed F. Salem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016318219","display_name":"Ranjini K. Sundaram","orcid":"https://orcid.org/0000-0002-5725-0284","observed_orcids":["https://orcid.org/0000-0002-5725-0284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ranjini K. Sundaram","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078249079","display_name":"Jeanne Chiaravalli","orcid":"https://orcid.org/0000-0001-9135-4565","observed_orcids":["https://orcid.org/0000-0001-9135-4565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeanne Chiaravalli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009036611","display_name":"Petrus J. Hendrikx","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petrus J. Hendrikx","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063107522","display_name":"Jennifer A. Wilshire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer A. Wilshire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089227056","display_name":"Maria Jasin","orcid":"https://orcid.org/0000-0002-7976-2379","observed_orcids":["https://orcid.org/0000-0002-7976-2379"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Jasin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001175430","display_name":"Harriet M. Kluger","orcid":"https://orcid.org/0000-0002-4932-9873","observed_orcids":["https://orcid.org/0000-0002-4932-9873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harriet M. Kluger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008177492","display_name":"J. Fraser Glickman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Fraser Glickman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056895130","display_name":"Simon N. Powell","orcid":"https://orcid.org/0000-0002-8183-4765","observed_orcids":["https://orcid.org/0000-0002-8183-4765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon N. Powell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040738951","display_name":"Ranjit S. Bindra","orcid":"https://orcid.org/0000-0002-3255-0467","observed_orcids":["https://orcid.org/0000-0002-3255-0467"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ranjit S. Bindra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiosensitizers","display_name":"radiosensitizers","score":0.9539999961853027},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8690000176429749},{"id":"https://openalex.org/keywords/dna-repair-inhibitors","display_name":"DNA repair inhibitors","score":0.7509999871253967},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9539999961853027},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.9440000057220459},{"id":"https://openalex.org/keywords/high-throughput-screening-hits","display_name":"high-throughput screening hits","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7326644659042358},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.6504015326499939},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4407261908054352},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.4314590394496918},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4038164019584656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2604743540287018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2596804201602936},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.08138608932495117},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.05580982565879822},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22503643","doi":"https://doi.org/10.1158/1535-7163.22503643","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22503643","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplemental_Figure_3_from_Identification_of_Novel_Radiosensitizers_in_a_High-Throughput_Cell-Based_Screen_for_DSB_Repair_Inhibitors/22503643/1/files/39963097.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22503643.v1","doi":"https://doi.org/10.1158/1535-7163.22503643.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22503643.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22503643","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplemental_Figure_3_from_Identification_of_Novel_Radiosensitizers_in_a_High-Throughput_Cell-Based_Screen_for_DSB_Repair_Inhibitors/22503643","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22503643","doi":"https://doi.org/10.1158/1535-7163.22503643","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22503643","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplemental_Figure_3_from_Identification_of_Novel_Radiosensitizers_in_a_High-Throughput_Cell-Based_Screen_for_DSB_Repair_Inhibitors/22503643/1/files/39963097.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362482500.pdf","grobid_xml":"https://content.openalex.org/works/W4362482500.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392681501","https://openalex.org/W2164419505","https://openalex.org/W2595775277","https://openalex.org/W2106057323","https://openalex.org/W2492777075","https://openalex.org/W4362542079","https://openalex.org/W2075818408","https://openalex.org/W1992267167","https://openalex.org/W2750743944","https://openalex.org/W3083590824"],"abstract_inverted_index":{"Full":[0],"IC50":[1],"curves":[2],"for":[3,9],"mNHEJ,":[4],"HR":[5],"and":[6],"cell":[7],"viability":[8],"each":[10],"of":[11],"the":[12],"16":[13],"identified":[14],"hits":[15],"which":[16],"inhibit":[17],"DSB":[18],"repair":[19],"activity.":[20]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}