{"id":"https://openalex.org/W4362482014","doi":"https://doi.org/10.1158/1535-7163.22503955","title":"Supplementary Methods and Supplementary Figures S2-S6 from Quantitative Phosphoproteomics Reveals Wee1 Kinase as a Therapeutic Target in a Model of Proneural Glioblastoma","display_name":"Supplementary Methods and Supplementary Figures S2-S6 from Quantitative Phosphoproteomics Reveals Wee1 Kinase as a Therapeutic Target in a Model of Proneural Glioblastoma","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362482014","doi":"https://doi.org/10.1158/1535-7163.22503955"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22503955","doi":"https://doi.org/10.1158/1535-7163.22503955","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22503955","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.22503955","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017738788","display_name":"Rebecca S. Lescarbeau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca S. Lescarbeau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Liang Lei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liang Lei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013680777","display_name":"Katrina K. Bakken","orcid":"https://orcid.org/0009-0009-8900-0077","observed_orcids":["https://orcid.org/0009-0009-8900-0077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katrina K. Bakken","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066080208","display_name":"Peter A. Sims","orcid":"https://orcid.org/0000-0002-3921-4837","observed_orcids":["https://orcid.org/0000-0002-3921-4837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter A. Sims","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015247761","display_name":"Jann Nagina Sarkaria","orcid":"https://orcid.org/0000-0001-7489-4885","observed_orcids":["https://orcid.org/0000-0001-7489-4885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jann N. Sarkaria","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046673359","display_name":"Peter Canoll","orcid":"https://orcid.org/0000-0002-7001-0226","observed_orcids":["https://orcid.org/0000-0002-7001-0226"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Canoll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002079869","display_name":"Forest M. White","orcid":"https://orcid.org/0000-0002-1545-1651","observed_orcids":["https://orcid.org/0000-0002-1545-1651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Forest M. White","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wee1","display_name":"WEE1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/proneural-glioblastoma","display_name":"proneural glioblastoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.9380000233650208},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.875},{"id":"https://openalex.org/keywords/cdk1-phosphorylation","display_name":"CDK1 phosphorylation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9150000214576721},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":1.0}],"concepts":[{"id":"https://openalex.org/C2781252693","wikidata":"https://www.wikidata.org/wiki/Q7979264","display_name":"Wee1","level":5,"score":0.6403864026069641},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.597675085067749},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.5522841215133667},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5296546816825867},{"id":"https://openalex.org/C6675166","wikidata":"https://www.wikidata.org/wiki/Q7187538","display_name":"Phosphoproteomics","level":5,"score":0.5255899429321289},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5092135667800903},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.44975370168685913},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.37706679105758667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35235345363616943},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2676500082015991},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.20608869194984436},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15861395001411438},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.09908634424209595}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22503955","doi":"https://doi.org/10.1158/1535-7163.22503955","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22503955","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22503955.v1","doi":"https://doi.org/10.1158/1535-7163.22503955.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22503955.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39963412","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22503955","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Methods_and_Supplementary_Figures_S2-S6_from_Quantitative_Phosphoproteomics_Reveals_Wee1_Kinase_as_a_Therapeutic_Target_in_a_Model_of_Proneural_Glioblastoma/22503955","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22503955","doi":"https://doi.org/10.1158/1535-7163.22503955","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22503955","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362482014.pdf","grobid_xml":"https://content.openalex.org/works/W4362482014.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392697459","https://openalex.org/W2334319208","https://openalex.org/W2039442869","https://openalex.org/W2468740668","https://openalex.org/W4402829613","https://openalex.org/W2324243307","https://openalex.org/W6958294107","https://openalex.org/W3217300400","https://openalex.org/W2488344932","https://openalex.org/W4308977931"],"abstract_inverted_index":{"Supplementary":[0,10,29,48,61,73],"Methods:":[1],"Detailed":[2],"decryption":[3],"of":[4,14,33,79],"all":[5],"methods":[6],"in":[7,19,38,68],"the":[8,15,20,25,34,39,44],"manuscript.":[9],"Figure":[11,30,49,62,74],"S2.":[12],"Heatmap":[13,32],"125":[16],"phosphopeptides":[17,36],"quantified":[18,37],"first":[21],"tumor":[22,41],"cohort":[23,42],"and":[24,43,58,66,77],"normal":[26,45],"brain":[27,46],"tissues.":[28,47],"S3.":[31],"78":[35],"second":[40],"S4.":[50],"Immunoblots":[51],"to":[52],"characterize":[53],"primary":[54,70],"murine":[55,69,81],"cell":[56],"lines":[57],"CDK1":[59],"phosphorylation.":[60],"S5.":[63],"DNA":[64],"damage":[65],"apoptosis":[67],"GBM":[71],"cells.":[72,82],"S6.":[75],"Apoptosis":[76],"rescue":[78],"MGPP7":[80]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}