{"id":"https://openalex.org/W4362482002","doi":"https://doi.org/10.1158/1535-7163.22503721","title":"Supplementary Figure S3 from Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High-Risk TP53 Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence","display_name":"Supplementary Figure S3 from Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High-Risk TP53 Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362482002","doi":"https://doi.org/10.1158/1535-7163.22503721"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22503721","doi":"https://doi.org/10.1158/1535-7163.22503721","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22503721","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.22503721","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081618990","display_name":"Abdullah A. Osman","orcid":"https://orcid.org/0000-0002-6320-6255","observed_orcids":["https://orcid.org/0000-0002-6320-6255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdullah A. Osman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000413703","display_name":"Marcus M. Monroe","orcid":"https://orcid.org/0000-0001-8899-2304","observed_orcids":["https://orcid.org/0000-0001-8899-2304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcus M. Monroe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071550152","display_name":"Marcus V. Ortega Alves","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcus V. Ortega Alves","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073241820","display_name":"Ameeta A. Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ameeta A. Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024033300","display_name":"Panagiotis Katsonis","orcid":"https://orcid.org/0000-0002-7172-1644","observed_orcids":["https://orcid.org/0000-0002-7172-1644"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Panagiotis Katsonis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065481778","display_name":"Alison L. Fitzgerald","orcid":"https://orcid.org/0000-0002-7279-7907","observed_orcids":["https://orcid.org/0000-0002-7279-7907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alison L. Fitzgerald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082631468","display_name":"David M. Neskey","orcid":"https://orcid.org/0000-0003-2026-2406","observed_orcids":["https://orcid.org/0000-0003-2026-2406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David M. Neskey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088937494","display_name":"Mitchell J. Frederick","orcid":"https://orcid.org/0000-0002-0932-8809","observed_orcids":["https://orcid.org/0000-0002-0932-8809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitchell J. Frederick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112400933","display_name":"Sang Hyeok Woo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sang Hyeok Woo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071658477","display_name":"Carlos Caul\u0131\u0301n","orcid":"https://orcid.org/0000-0002-5059-0016","observed_orcids":["https://orcid.org/0000-0002-5059-0016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Caulin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034802496","display_name":"Teng\u2010Kuei Hsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teng-Kuei Hsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051162687","display_name":"Thomas O. McDonald","orcid":"https://orcid.org/0000-0002-5272-0187","observed_orcids":["https://orcid.org/0000-0002-5272-0187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas O. McDonald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071222148","display_name":"Marek Kimmel","orcid":"https://orcid.org/0000-0001-8161-890X","observed_orcids":["https://orcid.org/0000-0001-8161-890X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marek Kimmel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111506784","display_name":"Raymond E. Meyn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond E. Meyn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023680746","display_name":"Olivier Lichtarge","orcid":"https://orcid.org/0000-0003-4057-7122","observed_orcids":["https://orcid.org/0000-0003-4057-7122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivier Lichtarge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068859775","display_name":"Jeffrey N. Myers","orcid":"https://orcid.org/0000-0003-4767-3408","observed_orcids":["https://orcid.org/0000-0003-4767-3408"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey N. Myers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.4246000051498413,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mk-1775","display_name":"MK-1775","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.796999990940094},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mitotic-arrest","display_name":"mitotic arrest","score":0.996999979019165},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9399999976158142},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6714022159576416},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5324795246124268},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.47566336393356323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4423433542251587},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43118321895599365},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.41747650504112244},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.4122891426086426},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3590930700302124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34436744451522827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3226516842842102},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28725284337997437},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1062537133693695},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.09040716290473938}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.22503721","doi":"https://doi.org/10.1158/1535-7163.22503721","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22503721","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22503721","doi":"https://doi.org/10.1158/1535-7163.22503721","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22503721","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2091461259","https://openalex.org/W2149068418","https://openalex.org/W2406608798","https://openalex.org/W2406596433","https://openalex.org/W2066496973","https://openalex.org/W2460036924","https://openalex.org/W3120025342","https://openalex.org/W2021865845","https://openalex.org/W1971929983","https://openalex.org/W2100875939"],"abstract_inverted_index":{"The":[0],"underlying":[1],"synergy":[2],"between":[3],"cisplatin":[4],"and":[5],"MK-1775":[6],"in":[7],"HNSCC":[8],"is":[9],"not":[10],"mediated":[11],"by":[12],"apoptosis.":[13]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}