{"id":"https://openalex.org/W4362481545","doi":"https://doi.org/10.1158/1535-7163.22498464","title":"Supplementary Figure 2 from Inhibition of HSP90 with AUY922 Induces Synergy in HER2-Amplified Trastuzumab-Resistant Breast and Gastric Cancer","display_name":"Supplementary Figure 2 from Inhibition of HSP90 with AUY922 Induces Synergy in HER2-Amplified Trastuzumab-Resistant Breast and Gastric Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362481545","doi":"https://doi.org/10.1158/1535-7163.22498464"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22498464","doi":"https://doi.org/10.1158/1535-7163.22498464","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22498464","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.22498464","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019473289","display_name":"Zev A. Wainberg","orcid":"https://orcid.org/0000-0002-7142-1246","observed_orcids":["https://orcid.org/0000-0002-7142-1246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zev A. Wainberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078879489","display_name":"Adrian Anghel","orcid":"https://orcid.org/0000-0002-4526-5913","observed_orcids":["https://orcid.org/0000-0002-4526-5913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adrian Anghel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054706823","display_name":"Amy M. Rogers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy M. Rogers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009971985","display_name":"Amrita J. Desai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amrita J. Desai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054528392","display_name":"Ondrej Kalous","orcid":"https://orcid.org/0000-0002-3821-6603","observed_orcids":["https://orcid.org/0000-0002-3821-6603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ondrej Kalous","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045387212","display_name":"Dylan F. Conklin","orcid":"https://orcid.org/0000-0003-4708-0071","observed_orcids":["https://orcid.org/0000-0003-4708-0071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dylan Conklin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039664664","display_name":"Raul Ayala","orcid":"https://orcid.org/0009-0006-1044-2031","observed_orcids":["https://orcid.org/0009-0006-1044-2031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raul Ayala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028010756","display_name":"Neil A. O\u2019Brien","orcid":"https://orcid.org/0000-0001-7408-1091","observed_orcids":["https://orcid.org/0000-0001-7408-1091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil A. O'Brien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033930240","display_name":"Cornelia Quadt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cornelia Quadt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019036811","display_name":"Mikhail Akimov","orcid":"https://orcid.org/0000-0002-7467-4409","observed_orcids":["https://orcid.org/0000-0002-7467-4409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikhail Akimov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015491002","display_name":"Dennis J. Slamon","orcid":"https://orcid.org/0000-0002-6330-498X","observed_orcids":["https://orcid.org/0000-0002-6330-498X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis J. Slamon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073989429","display_name":"Richard S. Finn","orcid":"https://orcid.org/0000-0003-2494-2126","observed_orcids":["https://orcid.org/0000-0003-2494-2126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard S. Finn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.15870000422000885,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90-inhibition","display_name":"HSP90 inhibition","score":0.9729999899864197},{"id":"https://openalex.org/keywords/auy922","display_name":"AUY922","score":0.9869999885559082},{"id":"https://openalex.org/keywords/her2-amplification","display_name":"HER2 amplification","score":0.7910000085830688},{"id":"https://openalex.org/keywords/trastuzumab-resistance","display_name":"trastuzumab resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7839999794960022},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":1.0},{"id":"https://openalex.org/keywords/nci-n87-cells","display_name":"NCI-N87 cells","score":0.7720000147819519},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.8789941072463989},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43946000933647156},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4248155355453491},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40545082092285156},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3756917119026184},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.353951632976532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33786246180534363}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.22498464","doi":"https://doi.org/10.1158/1535-7163.22498464","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22498464","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22498464.v1","doi":"https://doi.org/10.1158/1535-7163.22498464.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22498464.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Inhibition_of_HSP90_with_AUY922_Induces_Synergy_in_HER2-Amplified_Trastuzumab-Resistant_Breast_and_Gastric_Cancer/22498464/1/files/39956844.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22498464","doi":"https://doi.org/10.1158/1535-7163.22498464","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22498464","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362481545.pdf","grobid_xml":"https://content.openalex.org/works/W4362481545.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392681213","https://openalex.org/W7099507215","https://openalex.org/W2126429511","https://openalex.org/W2048898687","https://openalex.org/W7096234282","https://openalex.org/W2533150528","https://openalex.org/W2034936246","https://openalex.org/W2793567915","https://openalex.org/W2338959727","https://openalex.org/W2343865822"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"2":[2],"PDF":[3],"file":[4],"-":[5],"91K,":[6],"Speed":[7],"of":[8,10],"recovery":[9],"downstream":[11],"targets":[12],"in":[13],"NCI-N87":[14]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
