{"id":"https://openalex.org/W4362481357","doi":"https://doi.org/10.1158/1535-7163.22500472","title":"Supplementary Figure 5 from Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases","display_name":"Supplementary Figure 5 from Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362481357","doi":"https://doi.org/10.1158/1535-7163.22500472"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22500472","doi":"https://doi.org/10.1158/1535-7163.22500472","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22500472","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.22500472","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102508315","display_name":"Kazuharu Kai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuharu Kai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110968220","display_name":"Kimie Kondo","orcid":"https://orcid.org/0009-0002-3270-278X","observed_orcids":["https://orcid.org/0009-0002-3270-278X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimie Kondo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100459932","display_name":"Xiaoping Wang","orcid":"https://orcid.org/0000-0003-4511-8638","observed_orcids":["https://orcid.org/0000-0003-4511-8638"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoping Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102508300","display_name":"Xuemei Xie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuemei Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009171221","display_name":"Mary Kathryn Pitner","orcid":"https://orcid.org/0009-0004-7423-6072","observed_orcids":["https://orcid.org/0009-0004-7423-6072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary K. Pitner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001759010","display_name":"Monica E. Reyes","orcid":"https://orcid.org/0000-0003-1433-0126","observed_orcids":["https://orcid.org/0000-0003-1433-0126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monica E. Reyes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063903344","display_name":"Angie M. Torres-Adorno","orcid":"https://orcid.org/0000-0003-0546-1570","observed_orcids":["https://orcid.org/0000-0003-0546-1570"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angie M. Torres-Adorno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047800296","display_name":"Hiroko Masuda","orcid":"https://orcid.org/0000-0002-4306-1298","observed_orcids":["https://orcid.org/0000-0002-4306-1298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroko Masuda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018617106","display_name":"Gabriel N. Hortob\u00e1gyi","orcid":"https://orcid.org/0000-0002-4873-4412","observed_orcids":["https://orcid.org/0000-0002-4873-4412","https://orcid.org/0000-0001-9030-4136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel N. Hortobagyi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011380404","display_name":"Chandra Bartholomeusz","orcid":"https://orcid.org/0000-0002-5806-1557","observed_orcids":["https://orcid.org/0000-0002-5806-1557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chandra Bartholomeusz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039137137","display_name":"Hideyuki Saya","orcid":"https://orcid.org/0000-0001-6610-1902","observed_orcids":["https://orcid.org/0000-0001-6610-1902"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideyuki Saya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110083321","display_name":"Debu Tripathy","orcid":"https://orcid.org/0000-0002-5711-2404","observed_orcids":["https://orcid.org/0000-0002-5711-2404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debu Tripathy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039200530","display_name":"Subrata Sen","orcid":"https://orcid.org/0000-0001-6884-6246","observed_orcids":["https://orcid.org/0000-0001-6884-6246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Subrata Sen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088814426","display_name":"Naoto Tada Ueno","orcid":"https://orcid.org/0000-0002-0166-7275","observed_orcids":["https://orcid.org/0000-0002-0166-7275","https://orcid.org/0000-0001-7104-0673"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoto T. Ueno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-knockout","display_name":"p53 knockout","score":0.7379999756813049},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8930000066757202},{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.734000027179718},{"id":"https://openalex.org/keywords/aurora-b-kinase","display_name":"Aurora B kinase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7429760694503784},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.7097424268722534},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4974954426288605},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4630252420902252},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4111279845237732},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40103018283843994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28942954540252686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2728383541107178},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12400701642036438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.22500472","doi":"https://doi.org/10.1158/1535-7163.22500472","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22500472","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22500472","doi":"https://doi.org/10.1158/1535-7163.22500472","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22500472","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2564226379","https://openalex.org/W4362495516","https://openalex.org/W2172610136","https://openalex.org/W2142218724","https://openalex.org/W2283179572","https://openalex.org/W2507470204","https://openalex.org/W1983483230","https://openalex.org/W3204686228","https://openalex.org/W7097270394","https://openalex.org/W1985822873"],"abstract_inverted_index":{"Knockout":[0],"of":[1],"p53":[2],"in":[3],"HCT116":[4],"colon":[5],"cancer":[6],"cells":[7],"treated":[8],"with":[9],"KW-2450.":[10]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-04-05T00:00:00"}