{"id":"https://openalex.org/W4362478331","doi":"https://doi.org/10.1158/1535-7163.c.6535699.v1","title":"Data from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II","display_name":"Data from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362478331","doi":"https://doi.org/10.1158/1535-7163.c.6535699.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6535699.v1","doi":"https://doi.org/10.1158/1535-7163.c.6535699.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6535699.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.c.6535699.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhipeng Meng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhipeng Meng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455265","display_name":"Tao Li","orcid":"https://orcid.org/0000-0001-9835-4744","observed_orcids":["https://orcid.org/0000-0001-9835-4744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100667081","display_name":"Xiaoxiao Ma","orcid":"https://orcid.org/0009-0007-6289-6120","observed_orcids":["https://orcid.org/0009-0007-6289-6120"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoxiao Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005713679","display_name":"Xiaoqiong Wang","orcid":"https://orcid.org/0000-0002-8554-4386","observed_orcids":["https://orcid.org/0000-0002-8554-4386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoqiong Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072957064","display_name":"Carl Van Ness","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl Van Ness","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027048026","display_name":"Yichao Gan","orcid":"https://orcid.org/0000-0003-4579-7941","observed_orcids":["https://orcid.org/0000-0003-4579-7941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yichao Gan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112878209","display_name":"Hong Zhou","orcid":"https://orcid.org/0009-0009-9774-6039","observed_orcids":["https://orcid.org/0009-0009-9774-6039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000223869","display_name":"Jinfen Tang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinfen Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002120493","display_name":"Guiyu Lou","orcid":"https://orcid.org/0000-0001-5549-4659","observed_orcids":["https://orcid.org/0000-0001-5549-4659"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guiyu Lou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039398140","display_name":"Yafan Wang","orcid":"https://orcid.org/0009-0001-1581-3958","observed_orcids":["https://orcid.org/0009-0001-1581-3958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yafan Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100341514","display_name":"Jun Wu","orcid":"https://orcid.org/0000-0003-0807-5229","observed_orcids":["https://orcid.org/0000-0003-0807-5229"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009104622","display_name":"Yun Yen","orcid":"https://orcid.org/0000-0003-0815-412X","observed_orcids":["https://orcid.org/0000-0003-0815-412X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun Yen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091690894","display_name":"Rongzhen Xu","orcid":"https://orcid.org/0000-0002-5865-0589","observed_orcids":["https://orcid.org/0000-0002-5865-0589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rongzhen Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071384941","display_name":"Wendong Huang","orcid":"https://orcid.org/0000-0003-3735-9466","observed_orcids":["https://orcid.org/0000-0003-3735-9466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wendong Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.17260000109672546,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/berbamine","display_name":"berbamine","score":1.0},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8679999709129333},{"id":"https://openalex.org/keywords/calcium-calmodulin-dependent-protein-kinase-ii","display_name":"calcium/calmodulin-dependent protein kinase II","score":0.9120000004768372},{"id":"https://openalex.org/keywords/camkii","display_name":"CaMKII","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5989999771118164},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6729999780654907},{"id":"https://openalex.org/keywords/camkii-phosphorylation","display_name":"CaMKII phosphorylation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.6539999842643738},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7330138087272644},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.6901211738586426},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6216388940811157},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6179139614105225},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5085552930831909},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4650462865829468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4139307737350464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.322883278131485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28272849321365356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1495860517024994}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.c.6535699.v1","doi":"https://doi.org/10.1158/1535-7163.c.6535699.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6535699.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6535699.v1","doi":"https://doi.org/10.1158/1535-7163.c.6535699.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6535699.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2160088467","https://openalex.org/W2980817214","https://openalex.org/W2082762354","https://openalex.org/W3122628553","https://openalex.org/W3186198382","https://openalex.org/W2751805847","https://openalex.org/W2374587160","https://openalex.org/W2017182462","https://openalex.org/W2062110065","https://openalex.org/W3178802253"],"abstract_inverted_index":{"Abstract":[0],"Liver":[1],"cancer":[2,9,18,38,60,65,84,117,126,137,163,174,190],"is":[3,19,25],"the":[4,41,78,91,108,122,149,166],"third":[5],"leading":[6],"cause":[7],"of":[8,43,53,82,94,105,110,114,124,134,157,170],"deaths":[10],"worldwide":[11],"but":[12],"no":[13],"effective":[14],"treatment":[15],"toward":[16],"liver":[17,37,59,83,95,125,136,145,162,173,189],"available":[20],"so":[21],"far.":[22],"Therefore,":[23],"there":[24],"an":[26],"unmet":[27],"medical":[28],"need":[29],"to":[30,34,128,187],"identify":[31],"novel":[32],"therapies":[33],"efficiently":[35],"treat":[36],"and":[39,51,63,89,120,165,181],"improve":[40],"prognosis":[42],"this":[44],"disease.":[45],"Here,":[46],"we":[47],"report":[48],"that":[49,140,179],"berbamine":[50,76,129,171,180],"one":[52],"its":[54,182],"derivatives,":[55],"bbd24,":[56],"potently":[57],"suppressed":[58],"cell":[61,66,118],"proliferation":[62,119],"induced":[64],"death":[67],"by":[68,192],"targeting":[69,193],"Ca2+/calmodulin-dependent":[70],"protein":[71],"kinase":[72],"II":[73],"(CAMKII).":[74],"Furthermore,":[75],"inhibited":[77],"in":[79,86,144,159],"vivo":[80],"tumorigenicity":[81],"cells":[85,127],"NOD/SCID":[87],"mice":[88],"downregulated":[90],"self-renewal":[92],"abilities":[93],"cancer\u2013initiating":[96],"cells.":[97],"Chemical":[98],"inhibition":[99],"or":[100],"short":[101],"hairpin":[102],"RNA\u2013mediated":[103],"knockdown":[104],"CAMKII":[106,115,141,158],"recapitulated":[107],"effects":[109],"berbamine,":[111],"whereas":[112],"overexpression":[113],"promoted":[116],"increased":[121],"resistance":[123],"treatments.":[130],"Western":[131],"blot":[132],"analyses":[133],"human":[135,161],"specimens":[138],"showed":[139],"was":[142],"hyperphosphorylated":[143],"tumors":[146],"compared":[147],"with":[148],"paired":[150],"peritumor":[151],"tissues,":[152],"which":[153],"supports":[154],"a":[155],"role":[156],"promoting":[160],"progression":[164],"potential":[167],"clinical":[168],"use":[169],"for":[172],"therapies.":[175],"Our":[176],"data":[177],"suggest":[178],"derivatives":[183],"are":[184],"promising":[185],"agents":[186],"suppress":[188],"growth":[191],"CAMKII.":[194],"Mol":[195],"Cancer":[196],"Ther;":[197],"12(10);":[198],"2067\u201377.":[199],"\u00a92013":[200],"AACR.":[201]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}
