{"id":"https://openalex.org/W4362478229","doi":"https://doi.org/10.1158/1535-7163.22499377","title":"Supplementary Figure 5 from Cotargeting Stress-Activated Hsp27 and Autophagy as a Combinatorial Strategy to Amplify Endoplasmic Reticular Stress in Prostate Cancer","display_name":"Supplementary Figure 5 from Cotargeting Stress-Activated Hsp27 and Autophagy as a Combinatorial Strategy to Amplify Endoplasmic Reticular Stress in Prostate Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362478229","doi":"https://doi.org/10.1158/1535-7163.22499377"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22499377","doi":"https://doi.org/10.1158/1535-7163.22499377","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22499377","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.22499377","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083970599","display_name":"Masafumi Kumano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masafumi Kumano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043410571","display_name":"Junya Furukawa","orcid":"https://orcid.org/0000-0001-8974-9218","observed_orcids":["https://orcid.org/0000-0001-8974-9218"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junya Furukawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015753910","display_name":"Masaki Shiota","orcid":"https://orcid.org/0000-0002-3306-4858","observed_orcids":["https://orcid.org/0000-0002-3306-4858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaki Shiota","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010896342","display_name":"Anousheh Zardan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anousheh Zardan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403486","display_name":"Fan Zhang","orcid":"https://orcid.org/0000-0002-6257-8911","observed_orcids":["https://orcid.org/0000-0002-6257-8911","https://orcid.org/0009-0009-3817-7083"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fan Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038938817","display_name":"Eliana Beraldi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eliana Beraldi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019160074","display_name":"Romina M. Wiedmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romina M. Wiedmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034110828","display_name":"Ladan Fazli","orcid":"https://orcid.org/0009-0005-0731-0583","observed_orcids":["https://orcid.org/0009-0005-0731-0583","https://orcid.org/0000-0001-6488-4245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ladan Fazli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081653545","display_name":"Amina Zoubeidi","orcid":"https://orcid.org/0000-0002-0498-142X","observed_orcids":["https://orcid.org/0000-0002-0498-142X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amina Zoubeidi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062125605","display_name":"Martin Edwin Gleave","orcid":"https://orcid.org/0000-0003-4235-0167","observed_orcids":["https://orcid.org/0000-0003-4235-0167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin E. Gleave","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.4311999976634979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.4311999976634979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.3433000147342682,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.15209999680519104,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp27","display_name":"HSP27","score":0.9670000076293945},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.753000020980835},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/3-methyladenine","display_name":"3-methyladenine","score":0.9079999923706055},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":1.0},{"id":"https://openalex.org/keywords/autophagy-inhibitors","display_name":"autophagy inhibitors","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.828000009059906},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8750389218330383},{"id":"https://openalex.org/C2779559962","wikidata":"https://www.wikidata.org/wiki/Q14905263","display_name":"Hsp27","level":5,"score":0.8524302244186401},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7052440643310547},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5924057364463806},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5070912837982178},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5021369457244873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4853934049606323},{"id":"https://openalex.org/C95190701","wikidata":"https://www.wikidata.org/wiki/Q3268002","display_name":"Reticular connective tissue","level":2,"score":0.47125008702278137},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4651094079017639},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.4112808108329773},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.3735445737838745},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.320288747549057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24721065163612366},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22025418281555176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2105633020401001},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.193627268075943},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.1660153567790985},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.12477859854698181},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08527752757072449},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08487504720687866},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05978831648826599}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22499377","doi":"https://doi.org/10.1158/1535-7163.22499377","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22499377","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22499377.v1","doi":"https://doi.org/10.1158/1535-7163.22499377.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22499377.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_Cotargeting_Stress-Activated_Hsp27_and_Autophagy_as_a_Combinatorial_Strategy_to_Amplify_Endoplasmic_Reticular_Stress_in_Prostate_Cancer/22499377/1/files/39957757.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22499377","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_Cotargeting_Stress-Activated_Hsp27_and_Autophagy_as_a_Combinatorial_Strategy_to_Amplify_Endoplasmic_Reticular_Stress_in_Prostate_Cancer/22499377","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22499377","doi":"https://doi.org/10.1158/1535-7163.22499377","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22499377","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362478229.pdf","grobid_xml":"https://content.openalex.org/works/W4362478229.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098678446","https://openalex.org/W2119528020","https://openalex.org/W4362477439","https://openalex.org/W2073789788","https://openalex.org/W4384071415","https://openalex.org/W2138482985","https://openalex.org/W3177437863","https://openalex.org/W4384070822","https://openalex.org/W1987710508","https://openalex.org/W2315287648"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"164K,":[3],"Combination":[4],"of":[5],"Hsp27":[6],"inhibition":[7],"with":[8],"autophagy":[9],"inhibitors":[10],"3-Methyladenine":[11],"(3-MA)":[12],"or":[13],"Chloroquine":[14],"(CQ)":[15],"increases":[16],"cytotoxicity":[17],"in":[18],"PC3":[19],"cells":[20]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}