{"id":"https://openalex.org/W4362477408","doi":"https://doi.org/10.1158/1535-7163.22498155","title":"Supplementary Figure 1 from Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF-\u03baB Pathways","display_name":"Supplementary Figure 1 from Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF-\u03baB Pathways","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362477408","doi":"https://doi.org/10.1158/1535-7163.22498155"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22498155","doi":"https://doi.org/10.1158/1535-7163.22498155","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22498155","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Protein_Kinase_C_Inhibitor_AEB071_Targets_Ocular_Melanoma_Harboring_GNAQ_Mutations_via_Effects_on_the_PKC_Erk1_2_and_PKC_NF-_B_Pathways/22498155/1/files/39956511.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Protein_Kinase_C_Inhibitor_AEB071_Targets_Ocular_Melanoma_Harboring_GNAQ_Mutations_via_Effects_on_the_PKC_Erk1_2_and_PKC_NF-_B_Pathways/22498155/1/files/39956511.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103093153","display_name":"Xinqi Wu","orcid":"https://orcid.org/0000-0003-4979-4596","observed_orcids":["https://orcid.org/0000-0003-4979-4596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinqi Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100338370","display_name":"Jingjing Li","orcid":"https://orcid.org/0000-0002-0661-5642","observed_orcids":["https://orcid.org/0000-0002-0661-5642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingjing Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049104586","display_name":"Meijun J. Zhu","orcid":"https://orcid.org/0000-0001-8027-1780","observed_orcids":["https://orcid.org/0000-0001-8027-1780"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meijun Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070886570","display_name":"Jonathan A. Fletcher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan A. Fletcher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084967339","display_name":"Frank Stephen Hodi","orcid":"https://orcid.org/0000-0001-6825-091X","observed_orcids":["https://orcid.org/0000-0001-6825-091X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Stephen Hodi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c-inhibitors","display_name":"PKC inhibitors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ocular-melanoma","display_name":"ocular melanoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gnaq-mutation","display_name":"GNAQ mutation","score":0.984000027179718},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.7919999957084656},{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2779176653","wikidata":"https://www.wikidata.org/wiki/Q18026236","display_name":"GNAQ","level":4,"score":0.9866768717765808},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.7828809022903442},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5315321087837219},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43215325474739075},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.43211886286735535},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4054338037967682},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3922997713088989},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36174649000167847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3557484745979309},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35510939359664917},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18946322798728943},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07395148277282715}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22498155","doi":"https://doi.org/10.1158/1535-7163.22498155","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22498155","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Protein_Kinase_C_Inhibitor_AEB071_Targets_Ocular_Melanoma_Harboring_GNAQ_Mutations_via_Effects_on_the_PKC_Erk1_2_and_PKC_NF-_B_Pathways/22498155/1/files/39956511.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22498155.v1","doi":"https://doi.org/10.1158/1535-7163.22498155.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22498155.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22498155","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Protein_Kinase_C_Inhibitor_AEB071_Targets_Ocular_Melanoma_Harboring_GNAQ_Mutations_via_Effects_on_the_PKC_Erk1_2_and_PKC_NF-_B_Pathways/22498155","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22498155","doi":"https://doi.org/10.1158/1535-7163.22498155","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22498155","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Protein_Kinase_C_Inhibitor_AEB071_Targets_Ocular_Melanoma_Harboring_GNAQ_Mutations_via_Effects_on_the_PKC_Erk1_2_and_PKC_NF-_B_Pathways/22498155/1/files/39956511.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362477408.pdf","grobid_xml":"https://content.openalex.org/works/W4362477408.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362478300","https://openalex.org/W2135453874","https://openalex.org/W4392681231","https://openalex.org/W2039939270","https://openalex.org/W2090787537","https://openalex.org/W2150039434","https://openalex.org/W2090640662","https://openalex.org/W2603902604","https://openalex.org/W2106628108","https://openalex.org/W2138896279"],"abstract_inverted_index":{"PDF":[0],"file,":[1],"41KB,":[2],"AEB071":[3],"selectively":[4],"reduced":[5],"viability":[6],"of":[7],"GNAQ":[8],"mutated":[9],"UM":[10],"cells.":[11]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
