{"id":"https://openalex.org/W4362476895","doi":"https://doi.org/10.1158/1535-7163.c.6537124","title":"Data from \u03b2III-Tubulin Regulates Breast Cancer Metastases to the Brain","display_name":"Data from \u03b2III-Tubulin Regulates Breast Cancer Metastases to the Brain","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362476895","doi":"https://doi.org/10.1158/1535-7163.c.6537124"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6537124","doi":"https://doi.org/10.1158/1535-7163.c.6537124","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6537124","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.c.6537124","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010241998","display_name":"Deepak Kanojia","orcid":"https://orcid.org/0000-0003-4295-4972","observed_orcids":["https://orcid.org/0000-0003-4295-4972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deepak Kanojia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029807840","display_name":"Ramin A. Morshed","orcid":"https://orcid.org/0000-0001-8464-6041","observed_orcids":["https://orcid.org/0000-0001-8464-6041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramin A. Morshed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012035250","display_name":"Lingjiao Zhang","orcid":"https://orcid.org/0000-0003-0700-4584","observed_orcids":["https://orcid.org/0000-0003-0700-4584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingjiao Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074786388","display_name":"Jason M. Miska","orcid":"https://orcid.org/0000-0001-9608-2810","observed_orcids":["https://orcid.org/0000-0001-9608-2810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason M. Miska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100552417","display_name":"Jian Qiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Qiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080991651","display_name":"Julius W. Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julius W. Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040841932","display_name":"Peter Pytel","orcid":"https://orcid.org/0000-0001-9506-4709","observed_orcids":["https://orcid.org/0000-0001-9506-4709"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Pytel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030768660","display_name":"Irina V. Balyasnikova","orcid":"https://orcid.org/0000-0002-4664-9441","observed_orcids":["https://orcid.org/0000-0002-4664-9441"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irina V. Balyasnikova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053972433","display_name":"Maciej S. Lesniak","orcid":"https://orcid.org/0000-0002-0096-5107","observed_orcids":["https://orcid.org/0000-0002-0096-5107","https://orcid.org/0000-0002-6282-6583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maciej S. Lesniak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009246073","display_name":"Atique U. Ahmed","orcid":"https://orcid.org/0000-0003-4795-0188","observed_orcids":["https://orcid.org/0000-0003-4795-0188"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atique U. Ahmed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.043699998408555984,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-brain-metastases","display_name":"breast cancer brain metastasis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/beta-iii-tubulin","display_name":"TUBB3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuronal-markers","display_name":"neuronal markers","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5649999976158142},{"id":"https://openalex.org/keywords/brain-microenvironment","display_name":"brain microenvironment","score":0.7170000076293945},{"id":"https://openalex.org/keywords/integrin-beta3","display_name":"CD61","score":0.8799999952316284},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9240000247955322},{"id":"https://openalex.org/keywords/src-signaling","display_name":"Src signaling","score":0.7680000066757202},{"id":"https://openalex.org/keywords/metastatic-potential","display_name":"metastatic potential","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.726544976234436},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.6472192406654358},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5843807458877563},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5760496854782104},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5739995241165161},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5311347842216492},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4901469647884369},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46459221839904785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38904592394828796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38541826605796814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36086025834083557},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3242577612400055},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.20987427234649658},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.c.6537124","doi":"https://doi.org/10.1158/1535-7163.c.6537124","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6537124","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.c.6537124.v1","doi":"https://doi.org/10.1158/1535-7163.c.6537124.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6537124.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6537124","doi":"https://doi.org/10.1158/1535-7163.c.6537124","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6537124","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038716277","https://openalex.org/W2065072950","https://openalex.org/W4301657462","https://openalex.org/W7148887475","https://openalex.org/W4407613436","https://openalex.org/W7223236887","https://openalex.org/W4386293400","https://openalex.org/W4387023814","https://openalex.org/W2589597106","https://openalex.org/W4416084848"],"abstract_inverted_index":{"Abstract":[0],"Brain":[1],"metastases":[2,99],"occur":[3],"in":[4,15,53,76,87,95,115,127,150,155,167,173,186],"about":[5],"10%":[6],"to":[7,23,32,191],"30%":[8],"of":[9,61,68,92,139,184],"breast":[10,39,79,96,116,159,192],"cancer":[11,40,80,97,117,160,193],"patients,":[12],"which":[13,123],"culminates":[14],"a":[16,59,156,174,181],"poor":[17],"prognosis.":[18],"It":[19],"is,":[20],"therefore,":[21],"critical":[22,182],"understand":[24],"the":[25,54],"molecular":[26],"mechanisms":[27],"underlying":[28],"brain":[29,55,77,98,157,175,188],"metastatic":[30,78,158,165,189],"processes":[31],"identify":[33],"relevant":[34],"targets.":[35],"We":[36,57],"hypothesized":[37],"that":[38,46],"cells":[41,132],"must":[42],"express":[43],"brain-associated":[44],"markers":[45,63,71],"would":[47],"enable":[48],"their":[49,128],"invasion":[50],"and":[51,64,74,101,121,148,169],"survival":[52,172],"microenvironment.":[56],"assessed":[58],"panel":[60],"brain-predominant":[62],"found":[65],"an":[66],"elevation":[67],"several":[69],"neuronal":[70,84],"(\u03b2III-tubulin,":[72],"Nestin,":[73],"AchE)":[75],"cells.":[81,194],"Among":[82],"these":[83],"predominant":[85],"markers,":[86],"silico":[88],"analysis":[89],"revealed":[90,124],"overexpression":[91],"\u03b2III-tubulin":[93],"(TUBB3)":[94],"(BCBM)":[100],"its":[102,164],"expression":[103],"was":[104],"significantly":[105,170],"associated":[106],"with":[107,133],"distant":[108],"metastases.":[109],"TUBB3":[110,135,153,185],"knockdown":[111,154],"studies":[112],"were":[113],"conducted":[114],"models":[118],"(MDA-Br,":[119],"GLIM2,":[120],"MDA-MB-468),":[122],"significant":[125],"reduction":[126],"invasive":[129],"capabilities.":[130],"MDA-Br":[131],"suppressed":[134],"also":[136],"demonstrated":[137],"loss":[138],"key":[140],"signaling":[141],"molecules":[142],"such":[143],"as":[144],"\u03b23":[145],"integrin,":[146],"pFAK,":[147],"pSrc":[149],"vitro.":[151],"Furthermore,":[152],"cell":[161],"line":[162],"compromised":[163],"ability":[166],"vivo,":[168],"improved":[171],"metastasis":[176],"model.":[177],"These":[178],"results":[179],"implicate":[180],"role":[183],"conferring":[187],"potential":[190],"Mol":[195],"Cancer":[196],"Ther;":[197],"14(5);":[198],"1152\u201361.":[199],"\u00a92015":[200],"AACR.":[201]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-05T00:00:00"}
