{"id":"https://openalex.org/W4362476815","doi":"https://doi.org/10.1158/1535-7163.c.6536851","title":"Data from Small Molecule BMH-Compounds That Inhibit RNA Polymerase I and Cause Nucleolar Stress","display_name":"Data from Small Molecule BMH-Compounds That Inhibit RNA Polymerase I and Cause Nucleolar Stress","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362476815","doi":"https://doi.org/10.1158/1535-7163.c.6536851"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6536851","doi":"https://doi.org/10.1158/1535-7163.c.6536851","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6536851","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.c.6536851","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036333727","display_name":"Karita Peltonen","orcid":"https://orcid.org/0000-0002-3063-451X","observed_orcids":["https://orcid.org/0000-0002-3063-451X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karita Peltonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049039046","display_name":"Laureen C. Colis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laureen Colis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057451470","display_name":"Hester Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hester Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081198623","display_name":"Sari J\u00e4\u00e4maa","orcid":"https://orcid.org/0009-0005-7922-9127","observed_orcids":["https://orcid.org/0009-0005-7922-9127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sari J\u00e4\u00e4maa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101857587","display_name":"Zhewei Zhang","orcid":"https://orcid.org/0000-0002-1431-2297","observed_orcids":["https://orcid.org/0000-0002-1431-2297"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhewei Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069613888","display_name":"Taija af H\u00e4llstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taija af H\u00e4llstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031991401","display_name":"Henna M. Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henna M. Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075165001","display_name":"Paul Sirajuddin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Sirajuddin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028508240","display_name":"Marikki Laiho","orcid":"https://orcid.org/0000-0002-5625-6430","observed_orcids":["https://orcid.org/0000-0002-5625-6430"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marikki Laiho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.2833999991416931,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-polymerase-i-inhibition","display_name":"RNA polymerase I inhibition","score":0.9020000100135803},{"id":"https://openalex.org/keywords/nucleolar-stress","display_name":"nucleolar stress","score":0.925000011920929},{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/nucleolar-segregation","display_name":"nucleolar segregation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/small-molecule-anticancer-drugs","display_name":"small molecule anticancer agents","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.7792339324951172},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6650466918945312},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5515062808990479},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4643931984901428},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.43024203181266785},{"id":"https://openalex.org/C25281209","wikidata":"https://www.wikidata.org/wiki/Q3502188","display_name":"RNA polymerase I","level":5,"score":0.42827263474464417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4226037859916687},{"id":"https://openalex.org/C131140672","wikidata":"https://www.wikidata.org/wiki/Q2031164","display_name":"Processivity","level":4,"score":0.4216974377632141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.408210426568985},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.3953637480735779},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.385986328125},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.33770251274108887},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33092883229255676},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.27211180329322815},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22035309672355652},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.1786612570285797},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17249014973640442},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10056781768798828},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.c.6536851","doi":"https://doi.org/10.1158/1535-7163.c.6536851","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6536851","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.c.6536851.v1","doi":"https://doi.org/10.1158/1535-7163.c.6536851.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6536851.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6536851","doi":"https://doi.org/10.1158/1535-7163.c.6536851","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6536851","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2120344444","https://openalex.org/W7223139068","https://openalex.org/W2033742799","https://openalex.org/W4406248660","https://openalex.org/W3215648870","https://openalex.org/W2797752654","https://openalex.org/W4282934974","https://openalex.org/W4309002785","https://openalex.org/W4282974450","https://openalex.org/W1528894011"],"abstract_inverted_index":{"Abstract":[0],"Activation":[1],"of":[2,28,51,64,91,98,103,124,147,195,204],"the":[3,29,43,62,99,109,125,166,183,201],"p53":[4,32,196,210],"pathway":[5,211],"has":[6,71],"been":[7],"considered":[8],"a":[9,24,101,114],"therapeutic":[10],"strategy":[11],"to":[12],"target":[13],"cancers.":[14],"We":[15,46,75],"have":[16],"previously":[17],"identified":[18],"several":[19],"p53-activating":[20],"small":[21],"molecules":[22,219],"in":[23,42,82,113,136,165],"cell-based":[25],"screen.":[26],"Two":[27],"compounds":[30,81,110],"activated":[31],"by":[33,188],"causing":[34],"DNA":[35],"damage,":[36],"but":[37],"this":[38,83],"modality":[39],"was":[40,134],"absent":[41],"other":[44],"four.":[45],"recently":[47],"showed":[48,151,171],"that":[49,78,152,182],"one":[50],"these,":[52],"BMH-21,":[53],"inhibits":[54],"RNA":[55],"polymerase":[56],"I":[57,66,105,185,206,222],"(Pol":[58],"I)":[59],"transcription,":[60],"causes":[61],"degradation":[63],"Pol":[65,104,184,205,221],"catalytic":[67],"subunit":[68],"RPA194,":[69],"and":[70,87,117,122,130,163,191,213],"potent":[72,172],"anticancer":[73,173],"activity.":[74],"show":[76,181],"here":[77],"three":[79],"remaining":[80],"screen,":[84],"BMH-9,":[85,161,189],"BMH-22,":[86,162,190],"BMH-23,":[88],"cause":[89],"reorganization":[90],"nucleolar":[92,132],"marker":[93],"proteins":[94],"consistent":[95],"with":[96],"segregation":[97],"nucleolus,":[100],"hallmark":[102],"transcription":[106,186,207],"stress.":[107],"Further,":[108],"destabilize":[111],"RPA194":[112],"proteasome-dependent":[115],"manner":[116],"inhibit":[118],"nascent":[119],"rRNA":[120,127],"synthesis":[121],"expression":[123],"45S":[126],"precursor.":[128],"BMH-9\u2013":[129],"BMH-22\u2013mediated":[131],"stress":[133,187,208],"detected":[135],"ex":[137],"vivo\u2013cultured":[138],"human":[139],"prostate":[140],"tissues":[141],"indicating":[142],"good":[143],"tissue":[144],"bioactivity.":[145],"Testing":[146],"closely":[148],"related":[149],"analogues":[150],"their":[153],"activities":[154],"were":[155],"chemically":[156,216],"constrained.":[157],"Viability":[158],"screen":[159],"for":[160,220],"BMH-23":[164,192],"NCI60":[167],"cancer":[168,226],"cell":[169],"lines":[170],"activity":[174],"across":[175],"many":[176],"tumor":[177],"types.":[178],"Finally,":[179],"we":[180],"is":[193],"independent":[194],"function.":[197],"These":[198],"results":[199],"highlight":[200],"dominant":[202],"impact":[203],"on":[209],"activation":[212],"bring":[214],"forward":[215],"novel":[217],"lead":[218],"inhibition,":[223],"and,":[224],"potentially,":[225],"targeting.":[227],"Mol":[228],"Cancer":[229],"Ther;":[230],"13(11);":[231],"2537\u201346.":[232],"\u00a92014":[233],"AACR.":[234]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}
