{"id":"https://openalex.org/W4362452189","doi":"https://doi.org/10.1016/j.cbi.2023.110470","title":"Protease-activated receptors in kidney diseases: A comprehensive review of pathological roles, therapeutic outcomes and challenges","display_name":"Protease-activated receptors in kidney diseases: A comprehensive review of pathological roles, therapeutic outcomes and challenges","publication_year":2023,"publication_date":"2023-04-01","ids":{"openalex":"https://openalex.org/W4362452189","doi":"https://doi.org/10.1016/j.cbi.2023.110470","pmid":"https://pubmed.ncbi.nlm.nih.gov/37011708"},"language":"en","primary_location":{"id":"doi:10.1016/j.cbi.2023.110470","doi":"https://doi.org/10.1016/j.cbi.2023.110470","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbi.2023.110470","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.authorea.com/doi/pdf/10.22541/au.164081642.27222358","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005399921","display_name":"Newly Bagang","orcid":"https://orcid.org/0000-0001-6684-4992","observed_orcids":["https://orcid.org/0000-0001-6684-4992"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]},{"id":"https://openalex.org/I76414455","display_name":"Kasturba Medical College, Manipal","ror":"https://ror.org/05hg48t65","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460","https://openalex.org/I76414455"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Newly Bagang","raw_affiliation_strings":["Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address: newlybagang@gmail.com","Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address: newlybagang@gmail.com","institution_ids":["https://openalex.org/I164861460","https://openalex.org/I76414455"]},{"raw_affiliation_string":"Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India","institution_ids":["https://openalex.org/I164861460","https://openalex.org/I76414455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071110452","display_name":"Kirti Gupta","orcid":"https://orcid.org/0000-0002-7038-4949","observed_orcids":["https://orcid.org/0000-0002-7038-4949"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kirti Gupta","raw_affiliation_strings":["International Graduate program of Medicines, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: kirtigupta17397@gmail.com","International Graduate program of Medicines, College of Medicine, Taipei Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Graduate program of Medicines, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: kirtigupta17397@gmail.com","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"International Graduate program of Medicines, College of Medicine, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007945945","display_name":"Gaaminepreet Singh","orcid":"https://orcid.org/0000-0003-4032-9049","observed_orcids":["https://orcid.org/0000-0003-4032-9049"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gaaminepreet Singh","raw_affiliation_strings":["Dept. of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. Electronic address: Gxs519@case.edu","Dept. of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-4032-9049","affiliations":[{"raw_affiliation_string":"Dept. of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. Electronic address: Gxs519@case.edu","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Dept. of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040735144","display_name":"Sri Harsha Kanuri","orcid":"https://orcid.org/0000-0003-0442-1489","observed_orcids":["https://orcid.org/0000-0003-0442-1489"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sri Harsha Kanuri","raw_affiliation_strings":["Dept. of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. Electronic address: sxk768@case.edu","Dept. of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. Electronic address: sxk768@case.edu","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Dept. of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057728839","display_name":"Sidharth Mehan","orcid":"https://orcid.org/0000-0003-0034-835X","observed_orcids":["https://orcid.org/0000-0003-0034-835X"]},"institutions":[{"id":"https://openalex.org/I4210092982","display_name":"Indo Soviet Friendship College of Pharmacy","ror":"https://ror.org/00fd30e02","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210092982"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sidharth Mehan","raw_affiliation_strings":["Department of Pharmacology, Indo-Soviet Friendship College of Pharmacy, Moga, Punjab, India. Electronic address: sidh.mehan@gmail.com","Department of Pharmacology, Indo-Soviet Friendship College of Pharmacy, Moga, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Indo-Soviet Friendship College of Pharmacy, Moga, Punjab, India. Electronic address: sidh.mehan@gmail.com","institution_ids":["https://openalex.org/I4210092982"]},{"raw_affiliation_string":"Department of Pharmacology, Indo-Soviet Friendship College of Pharmacy, Moga, Punjab, India","institution_ids":["https://openalex.org/I4210092982"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007945945"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":3410,"currency":"USD","value_usd":3410},"apc_paid":null,"fwci":1.4698,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.81615704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"377","issue":null,"first_page":"110470","last_page":"110470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7207000255584717,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7207000255584717,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.08330000191926956,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.06729999929666519,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protease-activated-receptors","display_name":"protease-activated receptors","score":1.0},{"id":"https://openalex.org/keywords/par1","display_name":"PAR1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/par2","display_name":"PAR2","score":1.0},{"id":"https://openalex.org/keywords/protease-activated-receptor-4","display_name":"PAR4","score":0.9350000023841858},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.8199999928474426},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/drug-induced-nephrotoxicity","display_name":"drug-induced nephrotoxicity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.7670000195503235},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.7960000038146973},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion-injury","display_name":"renal ischemia-reperfusion injury","score":0.9129999876022339},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.7549999952316284},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/kallikrein","display_name":"kallikrein","score":0.8740000128746033},{"id":"https://openalex.org/keywords/podocyte-apoptosis","display_name":"podocyte apoptosis","score":0.6480000019073486},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tubular-inflammation","display_name":"tubular inflammation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.718999981880188},{"id":"https://openalex.org/keywords/urethral-obstruction","display_name":"urethral obstruction","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5706821084022522},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5418989658355713},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5346822738647461},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4947583079338074},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.4583415985107422},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.44194984436035156},{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.43413421511650085},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41663020849227905},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28719469904899597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2612411081790924},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.09072461724281311},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044463","descriptor_name":"Receptor, PAR-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.cbi.2023.110470","doi":"https://doi.org/10.1016/j.cbi.2023.110470","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbi.2023.110470","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},{"id":"doi:10.22541/au.164081642.27222358/v1","doi":"https://doi.org/10.22541/au.164081642.27222358/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.164081642.27222358/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.164081642.27222358","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:37011708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37011708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-biological interactions","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.22541/au.164081642.27222358/v1","doi":"https://doi.org/10.22541/au.164081642.27222358/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.164081642.27222358/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.164081642.27222358","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362452189.pdf","grobid_xml":"https://content.openalex.org/works/W4362452189.grobid-xml"},"referenced_works_count":164,"referenced_works":["https://openalex.org/W11598776","https://openalex.org/W111526867","https://openalex.org/W1418915365","https://openalex.org/W1500271653","https://openalex.org/W1505008375","https://openalex.org/W1532257467","https://openalex.org/W1603713747","https://openalex.org/W1642728877","https://openalex.org/W1792093655","https://openalex.org/W1890604266","https://openalex.org/W1894886495","https://openalex.org/W1963938486","https://openalex.org/W1970282570","https://openalex.org/W1971799714","https://openalex.org/W1974726237","https://openalex.org/W1976629434","https://openalex.org/W1981243375","https://openalex.org/W1982054459","https://openalex.org/W1987188654","https://openalex.org/W1989499124","https://openalex.org/W1990817996","https://openalex.org/W1994169025","https://openalex.org/W1995692056","https://openalex.org/W1997958887","https://openalex.org/W1999647741","https://openalex.org/W2001314904","https://openalex.org/W2002730863","https://openalex.org/W2003171184","https://openalex.org/W2009629707","https://openalex.org/W2014862688","https://openalex.org/W2016060700","https://openalex.org/W2019744391","https://openalex.org/W2020164466","https://openalex.org/W2021916231","https://openalex.org/W2024792147","https://openalex.org/W2026332974","https://openalex.org/W2027454031","https://openalex.org/W2028031291","https://openalex.org/W2029539300","https://openalex.org/W2033181607","https://openalex.org/W2036563690","https://openalex.org/W2042673794","https://openalex.org/W2044347636","https://openalex.org/W2044804580","https://openalex.org/W2045516356","https://openalex.org/W2049774659","https://openalex.org/W2050588661","https://openalex.org/W2054755233","https://openalex.org/W2055298026","https://openalex.org/W2062208260","https://openalex.org/W2063819332","https://openalex.org/W2066640119","https://openalex.org/W2073218447","https://openalex.org/W2077012158","https://openalex.org/W2077293402","https://openalex.org/W2078546046","https://openalex.org/W2080814763","https://openalex.org/W2082092422","https://openalex.org/W2085983629","https://openalex.org/W2086196978","https://openalex.org/W2086640781","https://openalex.org/W2087509925","https://openalex.org/W2090436751","https://openalex.org/W2096242497","https://openalex.org/W2098019283","https://openalex.org/W2100197057","https://openalex.org/W2102235083","https://openalex.org/W2111255529","https://openalex.org/W2112543878","https://openalex.org/W2113830065","https://openalex.org/W2116365120","https://openalex.org/W2117714031","https://openalex.org/W2123629654","https://openalex.org/W2127637322","https://openalex.org/W2129601349","https://openalex.org/W2130696336","https://openalex.org/W2131419242","https://openalex.org/W2132302426","https://openalex.org/W2133834465","https://openalex.org/W2134552023","https://openalex.org/W2141030542","https://openalex.org/W2142221153","https://openalex.org/W2142541327","https://openalex.org/W2144582052","https://openalex.org/W2146916955","https://openalex.org/W2149516546","https://openalex.org/W2151438241","https://openalex.org/W2151998349","https://openalex.org/W2155939210","https://openalex.org/W2159231976","https://openalex.org/W2159594258","https://openalex.org/W2160578994","https://openalex.org/W2163499692","https://openalex.org/W2163605874","https://openalex.org/W2164235492","https://openalex.org/W2165255133","https://openalex.org/W2166999542","https://openalex.org/W2167440496","https://openalex.org/W2169158278","https://openalex.org/W2169712199","https://openalex.org/W2217446289","https://openalex.org/W2254213576","https://openalex.org/W2254471596","https://openalex.org/W2260987072","https://openalex.org/W2266760369","https://openalex.org/W2314664886","https://openalex.org/W2332354682","https://openalex.org/W2396212074","https://openalex.org/W2401755770","https://openalex.org/W2407574550","https://openalex.org/W2409073940","https://openalex.org/W2410449798","https://openalex.org/W2413748441","https://openalex.org/W2415371617","https://openalex.org/W2415651303","https://openalex.org/W2519905081","https://openalex.org/W2521011435","https://openalex.org/W2529874798","https://openalex.org/W2564738459","https://openalex.org/W2587141314","https://openalex.org/W2592877394","https://openalex.org/W2593771998","https://openalex.org/W2606390009","https://openalex.org/W2615714795","https://openalex.org/W2735568802","https://openalex.org/W2754072852","https://openalex.org/W2761931108","https://openalex.org/W2775434460","https://openalex.org/W2780394963","https://openalex.org/W2780954662","https://openalex.org/W2800995050","https://openalex.org/W2807725460","https://openalex.org/W2912708395","https://openalex.org/W2913317832","https://openalex.org/W2919287351","https://openalex.org/W2938493336","https://openalex.org/W2943435124","https://openalex.org/W2947174455","https://openalex.org/W2956038375","https://openalex.org/W2959093666","https://openalex.org/W2971377905","https://openalex.org/W2982578608","https://openalex.org/W3008074101","https://openalex.org/W3012685126","https://openalex.org/W3032510268","https://openalex.org/W3044253363","https://openalex.org/W3046809127","https://openalex.org/W3085699029","https://openalex.org/W3092730281","https://openalex.org/W3096075076","https://openalex.org/W3097013826","https://openalex.org/W3109646113","https://openalex.org/W3133252592","https://openalex.org/W3178443655","https://openalex.org/W3200958143","https://openalex.org/W3206563693","https://openalex.org/W4220981267","https://openalex.org/W4251417745","https://openalex.org/W4406058838","https://openalex.org/W6659002203","https://openalex.org/W6661254387","https://openalex.org/W6678939668","https://openalex.org/W6731089052","https://openalex.org/W6747315094"],"related_works":["https://openalex.org/W4200038618","https://openalex.org/W4407319979","https://openalex.org/W4389180095","https://openalex.org/W3012685126","https://openalex.org/W2529874798","https://openalex.org/W2044347636","https://openalex.org/W2912708395","https://openalex.org/W7143294464","https://openalex.org/W2951692649","https://openalex.org/W3092730281"],"abstract_inverted_index":{"Studies":[0],"have":[1,60,102,141],"demonstrated":[2],"that":[3,203],"protease-activated":[4],"receptors":[5],"(PARs)":[6],"with":[7],"four":[8],"subtypes":[9,42,140,169,196],"(PAR1-4)":[10],"are":[11,37,188],"mainly":[12],"expressed":[13],"in":[14,51,65,92,109,132,174,197],"the":[15,77,133,138,158,192,198],"renal":[16,95,181],"epithelial,":[17],"endothelial,":[18],"and":[19,24,31,58,70,99,115,117,126,130,167,180,215],"podocyte":[20,159],"cells.":[21],"Some":[22],"endogenous":[23],"urinary":[25],"proteases,":[26],"namely":[27],"thrombin,":[28],"trypsin,":[29],"urokinase,":[30],"kallikrein":[32],"released":[33],"during":[34,217],"diseased":[35],"conditions,":[36],"responsible":[38],"for":[39,147],"activating":[40],"different":[41],"of":[43,54,68,81,194],"PARs.":[44],"Each":[45],"PAR":[46],"receptor":[47],"subtype":[48],"is":[49],"involved":[50],"kidney":[52,73,177,218],"disease":[53,83],"distinct":[55,78],"aetiology.":[56],"PAR1":[57,98],"PAR2":[59,100,122,166],"shown":[61],"differential":[62],"therapeutic":[63,145],"outcomes":[64],"rodent":[66],"models":[67],"type-1":[69],"type-2":[71],"diabetic":[72,94],"diseases":[74],"due":[75],"to":[76,89,105,190],"etiological":[79],"basis":[80],"each":[82],"type,":[84],"however":[85],"such":[86],"findings":[87],"need":[88],"be":[90],"confirmed":[91],"other":[93,195],"injury":[96,178,183],"models.":[97,184],"blockers":[101],"been":[103,172],"observed":[104],"abolish":[106],"drug-induced":[107],"nephrotoxicity":[108],"rodents":[110],"by":[111],"suppressing":[112],"tubular":[113],"inflammation":[114],"fibrosis":[116],"preventing":[118],"mitochondrial":[119],"dysfunction.":[120],"Notably,":[121],"inhibition":[123],"improved":[124],"autophagy":[125],"prevented":[127],"fibrosis,":[128,212],"inflammation,":[129],"remodeling":[131],"urethral":[134],"obstruction":[135],"model.":[136,200],"Only":[137],"PAR1/4":[139],"emerged":[142],"as":[143],"a":[144],"target":[146],"treating":[148],"experimentally":[149],"induced":[150,161],"nephrotic":[151],"syndrome,":[152],"where":[153],"their":[154],"respective":[155],"antibodies":[156],"attenuated":[157],"apoptosis":[160,216],"upon":[162],"thrombin":[163],"activation.":[164],"Strikingly":[165],"PAR4":[168],"involvement":[170],"has":[171],"tested":[173],"sepsis-induced":[175],"acute":[176],"(AKI)":[179],"ischemia-reperfusion":[182],"Thus,":[185],"more":[186],"studies":[187],"required":[189],"delineate":[191],"role":[193],"sepsis-AKI":[199],"Evidence":[201],"suggests":[202],"PARs":[204],"regulate":[205],"oxidative,":[206],"inflammatory":[207],"stress,":[208],"immune":[209],"cell":[210],"activation,":[211],"autophagic":[213],"flux,":[214],"diseases.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-04-05T00:00:00"}