{"id":"https://openalex.org/W4362446428","doi":"https://doi.org/10.1158/0008-5472.22413281","title":"Supplementary Materials from A Model-Based Personalized Cancer Screening Strategy for Detecting Early-Stage Tumors Using Blood-Borne Biomarkers","display_name":"Supplementary Materials from A Model-Based Personalized Cancer Screening Strategy for Detecting Early-Stage Tumors Using Blood-Borne Biomarkers","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4362446428","doi":"https://doi.org/10.1158/0008-5472.22413281"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22413281","doi":"https://doi.org/10.1158/0008-5472.22413281","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22413281","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22413281","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082883632","display_name":"Sharon Seiko Hori","orcid":"https://orcid.org/0000-0002-4188-4952","observed_orcids":["https://orcid.org/0000-0002-4188-4952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharon Seiko Hori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076949598","display_name":"Amelie M. Lutz","orcid":"https://orcid.org/0000-0003-2844-7616","observed_orcids":["https://orcid.org/0000-0003-2844-7616"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amelie M. Lutz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018880989","display_name":"Ramasamy Paulmurugan","orcid":"https://orcid.org/0000-0001-7155-4738","observed_orcids":["https://orcid.org/0000-0001-7155-4738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramasamy Paulmurugan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019955301","display_name":"Sanjiv Sam Gambhir","orcid":"https://orcid.org/0000-0002-2711-7554","observed_orcids":["https://orcid.org/0000-0002-2711-7554"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjiv Sam Gambhir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7519999742507935},{"id":"https://openalex.org/keywords/blood-borne-biomarkers","display_name":"blood-borne biomarkers","score":0.8730000257492065},{"id":"https://openalex.org/keywords/seap","display_name":"SEAP","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mathematical-tumor-growth-model","display_name":"mathematical tumor growth model","score":0.6549999713897705},{"id":"https://openalex.org/keywords/two-compartment-model","display_name":"two-compartment model","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tumor-growth-prediction","display_name":"tumor growth prediction","score":0.460999995470047},{"id":"https://openalex.org/keywords/a2780-cells","display_name":"A2780 cells","score":0.7049999833106995},{"id":"https://openalex.org/keywords/hek293t-cells","display_name":"HEK293T cells","score":0.6480000019073486},{"id":"https://openalex.org/keywords/model-validation","display_name":"model validation","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6078641414642334},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5036317706108093},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.500584602355957},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49684789776802063},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4325403869152069},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41307687759399414},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3589332699775696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.341029554605484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3290337324142456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11996138095855713},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.22413281","doi":"https://doi.org/10.1158/0008-5472.22413281","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22413281","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22413281","doi":"https://doi.org/10.1158/0008-5472.22413281","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22413281","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2591773109","https://openalex.org/W4361823748","https://openalex.org/W2330848365","https://openalex.org/W2049113945","https://openalex.org/W2094550799","https://openalex.org/W1484440908","https://openalex.org/W2788744507","https://openalex.org/W3128177746","https://openalex.org/W2007347670","https://openalex.org/W825468358"],"abstract_inverted_index":{"The":[0],"Supplementary":[1,44,68,93,113,123,146,159,185,204,211,217,229],"Materials":[2],"contains":[3],"the":[4,14,21,26,89,164,177,190],"following:":[5],"1)":[6],"Derivation":[7],"of":[8,16,20,30,49,59,64,82,135,163,170,179,189,196,233],"Model":[9,23,36,238],"Steady":[10],"State":[11,208],"Conditions":[12],"in":[13,25,76,88,103,105,119,132,153,176,225],"Absence":[15,27],"Cancer;":[17,31],"2)":[18],"Validation":[19,239],"2-Compartment":[22],"Structure":[24],"and":[28,35,62,142],"Presence":[29],"3)":[32],"Parameter":[33,235],"Values":[34],"Assumptions":[37],"for":[38,56,139,237],"Simulating":[39],"Cancer":[40],"Patient":[41],"Screening;":[42],"4)":[43],"Fig.":[45,69,94,114,124,147,160,186],"S1":[46,206],"(Mathematical":[47],"modeling":[48],"blood":[50],"biomarker":[51,222],"data":[52],"can":[53],"be":[54],"used":[55,138],"personalized":[57,168,194],"detection":[58],"aggressive":[60,174,201],"disease":[61,175],"monitoring":[63],"non-aggressive":[65],"disease);":[66,202],"5)":[67],"S2":[70,213],"(Comparing":[71],"early":[72],"tumor":[73,101,130,150],"growth":[74,131,151],"using":[75],"vivo":[77,104],"FL":[78],"bioluminescence":[79],"following":[80],"implantation":[81],"A2780-SEAP-FL-eGFP":[83],"or":[84],"non-transfected":[85],"A2780":[86],"cells":[87],"mouse":[90,110],"ovary);":[91],"6)":[92],"S3":[95,219],"(Plasma":[96],"SEAP":[97],"levels":[98],"correlate":[99],"with":[100,172,198],"viability":[102],"a":[106,133],"subcutaneous":[107],"293T":[108],"xenograft":[109],"model);":[111],"7)":[112],"S4":[115,231],"(SEAP":[116],"shedding":[117,223],"rates":[118],"cell":[120],"culture);":[121],"8)":[122],"S5":[125],"(Model":[126,207,214],"validation":[127,156],"by":[128],"predicting":[129],"subset":[134],"mice":[136],"not":[137],"model":[140,166,192],"fitting":[141],"parameter":[143],"estimation);":[144],"9)":[145],"S6":[148],"(Predicted":[149],"parameters":[152],"clinically":[154],"relevant":[155],"study);":[157],"10)":[158],"S7":[161],"(Application":[162,188],"mathematical":[165,191],"to":[167,193],"screening":[169,195],"patients":[171,197],"asymptomatic":[173,199],"absence":[178],"technical":[180],"(assay":[181],"measurement)":[182],"error);":[183],"11)":[184],"S8":[187],"moderately":[200],"12)":[203],"Table":[205,212,218,230],"Variables);":[209],"13)":[210],"Parameters);":[215],"14)":[216],"(Estimating":[220],"cancer-specific":[221],"kinetics":[224],"living":[226],"mice);":[227],"15)":[228],"(Summary":[232],"Training":[234],"Estimates":[236],"Study)":[240]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}
