{"id":"https://openalex.org/W4362431165","doi":"https://doi.org/10.1158/0008-5472.22433040.v1","title":"Supplementary Data from Targeting DNA Repair with Combined Inhibition of NHEJ and MMEJ Induces Synthetic Lethality in TP53-Mutant Cancers","display_name":"Supplementary Data from Targeting DNA Repair with Combined Inhibition of NHEJ and MMEJ Induces Synthetic Lethality in TP53-Mutant Cancers","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4362431165","doi":"https://doi.org/10.1158/0008-5472.22433040.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22433040.v1","doi":"https://doi.org/10.1158/0008-5472.22433040.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22433040.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22433040.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025906425","display_name":"Jeffrey Patterson-Fortin","orcid":"https://orcid.org/0000-0001-8493-8060","observed_orcids":["https://orcid.org/0000-0001-8493-8060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey Patterson-Fortin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8493-8060","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076167474","display_name":"Arindam Bose","orcid":"https://orcid.org/0000-0003-2130-9544","observed_orcids":["https://orcid.org/0000-0003-2130-9544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arindam Bose","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2130-9544","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036174584","display_name":"Wei-Chih Tsai","orcid":"https://orcid.org/0000-0002-1886-6350","observed_orcids":["https://orcid.org/0000-0002-1886-6350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-Chih Tsai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1886-6350","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000948006","display_name":"Carter Grochala","orcid":"https://orcid.org/0000-0001-8064-1913","observed_orcids":["https://orcid.org/0000-0001-8064-1913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carter Grochala","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8064-1913","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005950027","display_name":"Huy Q. Nguyen","orcid":"https://orcid.org/0000-0002-4424-1047","observed_orcids":["https://orcid.org/0000-0002-4424-1047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huy Nguyen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4424-1047","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016112931","display_name":"Jia Zhou","orcid":"https://orcid.org/0000-0002-2156-0483","observed_orcids":["https://orcid.org/0000-0002-2156-0483"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia Zhou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2156-0483","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043442872","display_name":"Kalindi Parmar","orcid":"https://orcid.org/0000-0002-9522-1716","observed_orcids":["https://orcid.org/0000-0002-9522-1716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kalindi Parmar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9522-1716","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073858657","display_name":"Jean\u2010Bernard Lazaro","orcid":"https://orcid.org/0000-0002-9417-3388","observed_orcids":["https://orcid.org/0000-0002-9417-3388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Bernard Lazaro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9417-3388","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060953135","display_name":"Joyce F. Liu","orcid":"https://orcid.org/0000-0003-3888-3972","observed_orcids":["https://orcid.org/0000-0003-3888-3972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joyce Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3888-3972","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050753145","display_name":"Kelsey McQueen","orcid":"https://orcid.org/0000-0002-2448-0200","observed_orcids":["https://orcid.org/0000-0002-2448-0200"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelsey McQueen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2448-0200","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045419282","display_name":"Geoffrey Ira Shapiro","orcid":"https://orcid.org/0000-0002-3331-4095","observed_orcids":["https://orcid.org/0000-0002-3331-4095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey I. Shapiro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3331-4095","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075890039","display_name":"David Kozono","orcid":"https://orcid.org/0000-0002-8916-396X","observed_orcids":["https://orcid.org/0000-0002-8916-396X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Kozono","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8916-396X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044648110","display_name":"Alan D. D\u2019Andrea","orcid":"https://orcid.org/0000-0001-6168-6294","observed_orcids":["https://orcid.org/0000-0001-6168-6294","https://orcid.org/0000-0002-3672-8760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan D. D'Andrea","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6168-6294","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7020000219345093},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.949999988079071},{"id":"https://openalex.org/keywords/microhomology-mediated-end-joining","display_name":"microhomology-mediated end joining","score":0.9279999732971191},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.9464103579521179},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7669423222541809},{"id":"https://openalex.org/C20379349","wikidata":"https://www.wikidata.org/wiki/Q1720706","display_name":"Lethality","level":2,"score":0.7300978302955627},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5310561656951904},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.506951093673706},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.47606179118156433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37040817737579346},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3510188162326813},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28926172852516174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18839091062545776}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.22433040.v1","doi":"https://doi.org/10.1158/0008-5472.22433040.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22433040.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22433040","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Data_from_Targeting_DNA_Repair_with_Combined_Inhibition_of_NHEJ_and_MMEJ_Induces_Synthetic_Lethality_in_i_TP53_i_-Mutant_Cancers/22433040","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22433040.v1","doi":"https://doi.org/10.1158/0008-5472.22433040.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22433040.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392723528","https://openalex.org/W4292183961","https://openalex.org/W4282964471","https://openalex.org/W3149034333","https://openalex.org/W6922515803","https://openalex.org/W4387673747","https://openalex.org/W4238916956","https://openalex.org/W2560679504","https://openalex.org/W2772117249","https://openalex.org/W7134248160"],"abstract_inverted_index":{"Supplementary":[0],"Data":[1],"from":[2],"Targeting":[3],"DNA":[4],"Repair":[5],"with":[6],"Combined":[7],"Inhibition":[8],"of":[9],"NHEJ":[10],"and":[11],"MMEJ":[12],"Induces":[13],"Synthetic":[14],"Lethality":[15],"in":[16],"TP53-Mutant":[17],"Cancers":[18]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-05T00:00:00"}
