{"id":"https://openalex.org/W4362425956","doi":"https://doi.org/10.1158/1078-0432.22440663.v1","title":"Supplementary Data from Mitochondrial Mutations Contribute to HIF1\u03b1 Accumulation via Increased Reactive Oxygen Species and Up-regulated Pyruvate Dehydrogenease Kinase 2 in Head and Neck Squamous Cell Carcinoma","display_name":"Supplementary Data from Mitochondrial Mutations Contribute to HIF1\u03b1 Accumulation via Increased Reactive Oxygen Species and Up-regulated Pyruvate Dehydrogenease Kinase 2 in Head and Neck Squamous Cell Carcinoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4362425956","doi":"https://doi.org/10.1158/1078-0432.22440663.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22440663.v1","doi":"https://doi.org/10.1158/1078-0432.22440663.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22440663.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Mitochondrial_Mutations_Contribute_to_HIF1_Accumulation_via_Increased_Reactive_Oxygen_Species_and_Up-regulated_Pyruvate_Dehydrogenease_Kinase_2_in_Head_and_Neck_Squamous_Cell_Carcinoma/22440663/1/files/39891522.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Mitochondrial_Mutations_Contribute_to_HIF1_Accumulation_via_Increased_Reactive_Oxygen_Species_and_Up-regulated_Pyruvate_Dehydrogenease_Kinase_2_in_Head_and_Neck_Squamous_Cell_Carcinoma/22440663/1/files/39891522.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063835774","display_name":"Wenyue Sun","orcid":"https://orcid.org/0000-0003-1673-0895","observed_orcids":["https://orcid.org/0000-0003-1673-0895"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenyue Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108477975","display_name":"Shaoyu Zhou","orcid":"https://orcid.org/0000-0002-8649-7462","observed_orcids":["https://orcid.org/0000-0002-8649-7462","https://orcid.org/0000-0002-0336-7954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaoyu Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103849340","display_name":"Steven S. Chang","orcid":"https://orcid.org/0000-0002-8645-1392","observed_orcids":["https://orcid.org/0000-0002-8645-1392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven S. Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031455085","display_name":"Thomas McFate","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas McFate","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083669395","display_name":"Ajay Kumar Verma","orcid":"https://orcid.org/0000-0001-8006-8475","observed_orcids":["https://orcid.org/0000-0001-8006-8475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ajay Verma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017600358","display_name":"Joseph A. Califano","orcid":"https://orcid.org/0000-0002-4715-6761","observed_orcids":["https://orcid.org/0000-0002-4715-6761"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph A. Califano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-mutations","display_name":"mitochondrial mutations","score":0.9900000095367432},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.996999979019165},{"id":"https://openalex.org/keywords/pdk2","display_name":"PDK2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6955212354660034},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6191825866699219},{"id":"https://openalex.org/C2780854706","wikidata":"https://www.wikidata.org/wiki/Q900970","display_name":"Pyruvate kinase","level":4,"score":0.557993471622467},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.5422585010528564},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.48758548498153687},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4426470994949341},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43566304445266724},{"id":"https://openalex.org/C2994491419","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Squamous carcinoma","level":3,"score":0.4240262508392334},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.4220470190048218},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.41666823625564575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3897656202316284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34975677728652954},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.30907830595970154},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3055429458618164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28212666511535645},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.23537740111351013},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.19880574941635132},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19687476754188538},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18317845463752747},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1340819001197815},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11519506573677063},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10464721918106079},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22440663.v1","doi":"https://doi.org/10.1158/1078-0432.22440663.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22440663.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Mitochondrial_Mutations_Contribute_to_HIF1_Accumulation_via_Increased_Reactive_Oxygen_Species_and_Up-regulated_Pyruvate_Dehydrogenease_Kinase_2_in_Head_and_Neck_Squamous_Cell_Carcinoma/22440663/1/files/39891522.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22440663","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Data_from_Mitochondrial_Mutations_Contribute_to_HIF1_Accumulation_via_Increased_Reactive_Oxygen_Species_and_Up-regulated_Pyruvate_Dehydrogenease_Kinase_2_in_Head_and_Neck_Squamous_Cell_Carcinoma/22440663","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22440663.v1","doi":"https://doi.org/10.1158/1078-0432.22440663.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22440663.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Mitochondrial_Mutations_Contribute_to_HIF1_Accumulation_via_Increased_Reactive_Oxygen_Species_and_Up-regulated_Pyruvate_Dehydrogenease_Kinase_2_in_Head_and_Neck_Squamous_Cell_Carcinoma/22440663/1/files/39891522.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4362425956.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2129900098","https://openalex.org/W4361943831","https://openalex.org/W1979484027","https://openalex.org/W2004088511","https://openalex.org/W2019748669","https://openalex.org/W4313643596","https://openalex.org/W2057199368","https://openalex.org/W2169490414","https://openalex.org/W2436525055","https://openalex.org/W1027356788"],"abstract_inverted_index":{"Supplementary":[0],"Data":[1],"from":[2],"Mitochondrial":[3],"Mutations":[4],"Contribute":[5],"to":[6],"HIF1\u03b1":[7],"Accumulation":[8],"via":[9],"Increased":[10],"Reactive":[11],"Oxygen":[12],"Species":[13],"and":[14,22],"Up-regulated":[15],"Pyruvate":[16],"Dehydrogenease":[17],"Kinase":[18],"2":[19],"in":[20],"Head":[21],"Neck":[23],"Squamous":[24],"Cell":[25],"Carcinoma":[26]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-05T00:00:00"}