{"id":"https://openalex.org/W4362425014","doi":"https://doi.org/10.1158/0008-5472.22432232.v1","title":"Supplementary Data from Poziotinib Inhibits HER2-Mutant\u2013Driven Therapeutic Resistance and Multiorgan Metastasis in Breast Cancer","display_name":"Supplementary Data from Poziotinib Inhibits HER2-Mutant\u2013Driven Therapeutic Resistance and Multiorgan Metastasis in Breast Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4362425014","doi":"https://doi.org/10.1158/0008-5472.22432232.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22432232.v1","doi":"https://doi.org/10.1158/0008-5472.22432232.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22432232.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Poziotinib_Inhibits_HER2-Mutant_Driven_Therapeutic_Resistance_and_Multiorgan_Metastasis_in_Breast_Cancer/22432232/1/files/39878594.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Poziotinib_Inhibits_HER2-Mutant_Driven_Therapeutic_Resistance_and_Multiorgan_Metastasis_in_Breast_Cancer/22432232/1/files/39878594.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002817732","display_name":"Rashi Kalra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rashi Kalra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031743516","display_name":"Ching Hui Chen","orcid":"https://orcid.org/0000-0002-8365-3036","observed_orcids":["https://orcid.org/0000-0002-8365-3036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ching Hui Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8365-3036","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650251","display_name":"Junkai Wang","orcid":"https://orcid.org/0000-0003-4782-5790","observed_orcids":["https://orcid.org/0000-0003-4782-5790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junkai Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013589035","display_name":"Ahmad Bin Salam","orcid":"https://orcid.org/0000-0002-9315-3211","observed_orcids":["https://orcid.org/0000-0002-9315-3211"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmad Bin Salam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044175725","display_name":"Lacey Elizabeth Dobrolecki","orcid":"https://orcid.org/0000-0001-6839-629X","observed_orcids":["https://orcid.org/0000-0001-6839-629X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lacey E. Dobrolecki","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6839-629X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036328427","display_name":"Alaina N. Lewis","orcid":"https://orcid.org/0009-0009-8760-2293","observed_orcids":["https://orcid.org/0009-0009-8760-2293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alaina Lewis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022709255","display_name":"Christina Sallas","orcid":"https://orcid.org/0009-0005-2194-0522","observed_orcids":["https://orcid.org/0009-0005-2194-0522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina Sallas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060515951","display_name":"Clayton Clopton Yates","orcid":"https://orcid.org/0000-0001-5420-9852","observed_orcids":["https://orcid.org/0000-0001-5420-9852"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clayton C. Yates","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5420-9852","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023898240","display_name":"Carolina Guti\u00e9rrez","orcid":"https://orcid.org/0000-0002-2941-3461","observed_orcids":["https://orcid.org/0000-0002-2941-3461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolina Gutierrez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2941-3461","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031584638","display_name":"Balasubramanyam Karanam","orcid":"https://orcid.org/0000-0002-0782-2539","observed_orcids":["https://orcid.org/0000-0002-0782-2539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Balasubramanyam Karanam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024724100","display_name":"Meenakshi Anurag","orcid":"https://orcid.org/0000-0003-4379-5192","observed_orcids":["https://orcid.org/0000-0003-4379-5192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meenakshi Anurag","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4379-5192","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053893309","display_name":"Bora Lim","orcid":"https://orcid.org/0000-0002-4182-6058","observed_orcids":["https://orcid.org/0000-0002-4182-6058"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bora Lim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4182-6058","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057135409","display_name":"Matthew J. Ellis","orcid":"https://orcid.org/0000-0002-8467-8534","observed_orcids":["https://orcid.org/0000-0002-8467-8534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew J. Ellis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8467-8534","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028471851","display_name":"Shyam M. Kavuri","orcid":"https://orcid.org/0000-0002-3321-6727","observed_orcids":["https://orcid.org/0000-0002-3321-6727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shyam M. Kavuri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3321-6727","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poziotinib","display_name":"poziotinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/her2-mutation","display_name":"HER2 mutation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7229999899864197},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.9440000057220459},{"id":"https://openalex.org/keywords/multi-organ-metastasis","display_name":"multiple organ metastasis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/her2-tyrosine-kinase-inhibitor","display_name":"HER2 tyrosine kinase inhibitor","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.67316734790802},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6447202563285828},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6306600570678711},{"id":"https://openalex.org/C2993589390","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Breast cancer metastasis","level":5,"score":0.5900723338127136},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5195420384407043},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.5194151401519775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.516196072101593},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44990405440330505},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3708304166793823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3191748559474945},{"id":"https://openalex.org/C2992691968","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Cancer metastasis","level":4,"score":0.2997395992279053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19449180364608765},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08549904823303223},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08233031630516052}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.22432232.v1","doi":"https://doi.org/10.1158/0008-5472.22432232.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22432232.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Poziotinib_Inhibits_HER2-Mutant_Driven_Therapeutic_Resistance_and_Multiorgan_Metastasis_in_Breast_Cancer/22432232/1/files/39878594.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22432232","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Data_from_Poziotinib_Inhibits_HER2-Mutant_Driven_Therapeutic_Resistance_and_Multiorgan_Metastasis_in_Breast_Cancer/22432232","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22432232.v1","doi":"https://doi.org/10.1158/0008-5472.22432232.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22432232.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Poziotinib_Inhibits_HER2-Mutant_Driven_Therapeutic_Resistance_and_Multiorgan_Metastasis_in_Breast_Cancer/22432232/1/files/39878594.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5299999713897705,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362425014.pdf","grobid_xml":"https://content.openalex.org/works/W4362425014.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2155835698","https://openalex.org/W2076096978","https://openalex.org/W60055582","https://openalex.org/W2570537891","https://openalex.org/W2027683842","https://openalex.org/W2918051428","https://openalex.org/W4321371981","https://openalex.org/W2297039878","https://openalex.org/W2134945055","https://openalex.org/W4362424726"],"abstract_inverted_index":{"Supplementary":[0],"Data":[1],"from":[2],"Poziotinib":[3],"Inhibits":[4],"HER2-Mutant\u2013Driven":[5],"Therapeutic":[6],"Resistance":[7],"and":[8],"Multiorgan":[9],"Metastasis":[10],"in":[11],"Breast":[12],"Cancer":[13]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}