{"id":"https://openalex.org/W4362422147","doi":"https://doi.org/10.1158/0008-5472.22415355.v1","title":"Supplementary Data from Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution","display_name":"Supplementary Data from Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4362422147","doi":"https://doi.org/10.1158/0008-5472.22415355.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22415355.v1","doi":"https://doi.org/10.1158/0008-5472.22415355.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22415355.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.22415355.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090654138","display_name":"Shaon Chakrabarti","orcid":"https://orcid.org/0000-0002-7429-5927","observed_orcids":["https://orcid.org/0000-0002-7429-5927"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaon Chakrabarti","raw_affiliation_strings":["Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215","Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091861581","display_name":"Franziska Michor A","orcid":"https://orcid.org/0000-0003-4869-8842","observed_orcids":["https://orcid.org/0000-0003-4869-8842","https://orcid.org/0009-0003-8552-7767"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franziska Michor","raw_affiliation_strings":["Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215","Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9700000286102295},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.9890000224113464},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.9440000057220459},{"id":"https://openalex.org/keywords/computational-model","display_name":"computational model","score":0.6729999780654907},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.8970000147819519},{"id":"https://openalex.org/keywords/parameter-estimation","display_name":"parameter estimation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mathematical-modelling-of-cancer","display_name":"mathematical modelling of cancer","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.622826099395752},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5692250728607178},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4848552942276001},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4794794023036957},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.44163161516189575},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43626996874809265},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.43410539627075195},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.39232751727104187},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.34778887033462524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3217892050743103},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27582430839538574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19660961627960205},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07600772380828857},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.22415355.v1","doi":"https://doi.org/10.1158/0008-5472.22415355.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22415355.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22415355","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Data_from_Pharmacokinetics_and_Drug_Interactions_Determine_Optimum_Combination_Strategies_in_Computational_Models_of_Cancer_Evolution/22415355","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22415355.v1","doi":"https://doi.org/10.1158/0008-5472.22415355.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22415355.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2102787760"],"related_works":["https://openalex.org/W4361824304","https://openalex.org/W2618035748","https://openalex.org/W4361825037","https://openalex.org/W3036137756","https://openalex.org/W4362385200","https://openalex.org/W2564306535","https://openalex.org/W4361926142","https://openalex.org/W7111432575","https://openalex.org/W2049977830","https://openalex.org/W1946697391"],"abstract_inverted_index":{"Supplemental":[0],"data":[1],"for":[2,22],"the":[3,23,32],"main":[4,9],"manuscript.":[5],"Contains":[6],"derivations":[7],"of":[8,15,20],"formulae":[10],"used":[11],"in":[12,31],"text,":[13],"analysis":[14],"different":[16],"dosing":[17],"schedules,":[18],"estimation":[19],"parameters":[21],"TATTON":[24],"trial":[25],"and":[26],"discussions":[27],"regarding":[28],"assumptions":[29],"made":[30],"analysis.":[33]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2023-04-05T00:00:00"}