{"id":"https://openalex.org/W4362420072","doi":"https://doi.org/10.1158/0008-5472.22397312","title":"Supplementary Figure 2 from RANKL Expression, Function, and Therapeutic Targeting in Multiple Myeloma and Chronic Lymphocytic Leukemia","display_name":"Supplementary Figure 2 from RANKL Expression, Function, and Therapeutic Targeting in Multiple Myeloma and Chronic Lymphocytic Leukemia","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4362420072","doi":"https://doi.org/10.1158/0008-5472.22397312"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22397312","doi":"https://doi.org/10.1158/0008-5472.22397312","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22397312","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_RANKL_Expression_Function_and_Therapeutic_Targeting_in_Multiple_Myeloma_and_Chronic_Lymphocytic_Leukemia/22397312/1/files/39843020.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_RANKL_Expression_Function_and_Therapeutic_Targeting_in_Multiple_Myeloma_and_Chronic_Lymphocytic_Leukemia/22397312/1/files/39843020.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071199486","display_name":"Benjamin Joachim Schmiedel","orcid":"https://orcid.org/0000-0002-9103-9378","observed_orcids":["https://orcid.org/0000-0002-9103-9378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Joachim Schmiedel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037956017","display_name":"Carolin Andrea Scheible","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolin Andrea Scheible","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046999122","display_name":"Tina Nuebling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tina Nuebling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036009814","display_name":"Hans\u2010Georg Kopp","orcid":"https://orcid.org/0000-0002-0825-8888","observed_orcids":["https://orcid.org/0000-0002-0825-8888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans-Georg Kopp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031869321","display_name":"Stefan Wirths","orcid":"https://orcid.org/0000-0003-2494-9862","observed_orcids":["https://orcid.org/0000-0003-2494-9862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Wirths","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069602567","display_name":"Miyuki Azuma","orcid":"https://orcid.org/0000-0002-3529-4585","observed_orcids":["https://orcid.org/0000-0002-3529-4585"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miyuki Azuma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045281805","display_name":"Pascal Schneider","orcid":"https://orcid.org/0000-0003-0677-9409","observed_orcids":["https://orcid.org/0000-0003-0677-9409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pascal Schneider","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066615137","display_name":"Gundram Jung","orcid":"https://orcid.org/0000-0002-2831-2829","observed_orcids":["https://orcid.org/0000-0002-2831-2829"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gundram Jung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002838487","display_name":"Ludger Gro\u00dfe\u2010Hovest","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ludger Grosse-Hovest","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026255080","display_name":"Helmut Rainer Salih","orcid":"https://orcid.org/0000-0002-6719-1847","observed_orcids":["https://orcid.org/0000-0002-6719-1847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helmut Rainer Salih","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.21559999883174896,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.9549999833106995},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9559999704360962},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.8270000219345093},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/soluble-rankl","display_name":"soluble RANKL","score":0.8709999918937683},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7710000276565552},{"id":"https://openalex.org/keywords/therapeutic-targeting","display_name":"therapeutic targeting","score":0.5839999914169312},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7350000143051147},{"id":"https://openalex.org/keywords/rpmi-8226-cells","display_name":"RPMI 8226 cells","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.8344850540161133},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.8257082104682922},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5863385200500488},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.49477046728134155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3972470164299011},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3937009572982788},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39186447858810425},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37053942680358887},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3136780261993408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30713391304016113},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29939717054367065},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.133933424949646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09002327919006348},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.06817498803138733}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.22397312","doi":"https://doi.org/10.1158/0008-5472.22397312","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22397312","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_RANKL_Expression_Function_and_Therapeutic_Targeting_in_Multiple_Myeloma_and_Chronic_Lymphocytic_Leukemia/22397312/1/files/39843020.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22397312.v1","doi":"https://doi.org/10.1158/0008-5472.22397312.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22397312.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22397312","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_RANKL_Expression_Function_and_Therapeutic_Targeting_in_Multiple_Myeloma_and_Chronic_Lymphocytic_Leukemia/22397312","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22397312","doi":"https://doi.org/10.1158/0008-5472.22397312","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22397312","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_RANKL_Expression_Function_and_Therapeutic_Targeting_in_Multiple_Myeloma_and_Chronic_Lymphocytic_Leukemia/22397312/1/files/39843020.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362420072.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2560912368","https://openalex.org/W4392684669","https://openalex.org/W2164204445","https://openalex.org/W2538526833","https://openalex.org/W2979709920","https://openalex.org/W2980114195","https://openalex.org/W1514772132","https://openalex.org/W2584540558","https://openalex.org/W2761616369","https://openalex.org/W2552592374"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"264K,":[3],"(A)":[4],"The":[5,21,176],"ability":[6],"of":[7,30,70,76,104,118,125,131,153,172,178,232,234,280,291,318,321],"MM":[8,37,135,197,208,213],"cells":[9,33,38,72,80,139,156,198,209,214,226,274],"to":[10,83],"release":[11,46,66,249,299],"sRANKL":[12,47],"does":[13],"not":[14,44,121,200],"influence":[15],"NK":[16,32,71,126,155,192,225,273],"reactivity":[17,127,193],"induced":[18],"by":[19,128,162,202,246,262,296,311],"RANK-Fc-ADCC.":[20,129],"increase":[22,145],"in":[23,73,85,146,165,227,256,275,305,328],"cytotoxicity":[24,147],"(left)":[25,148,210,301],"and":[26,95,109,137,149,185,211,253,287,302,330],"cytokine":[27,65,150],"production":[28,151],"(right)":[29,152,215],"allogeneic":[31,154,224,272],"using":[34],"RANKL":[35,119,132,195,218,267],"surface-positive":[36],"that":[39,216],"do":[40,43,120],"(+sRANKL)":[41],"or":[42,64,230,240,278,282],"(-sRANKL)":[45],"as":[48,163],"targets":[49],"upon":[50,102,157],"treatment":[51,158],"with":[52,123,143,159,223,271,323],"RANK-Fc-ADCC":[53,160,281],"was":[54,81,100,141,244,294],"calculated.":[55],"To":[56],"this":[57],"end,":[58],"specific":[59],"lysis":[60],"(E:T":[61,67],"ratio":[62,68],"40:1)":[63],"1:1)":[69],"the":[74,144,170,203,228,235,276,288],"presence":[75,229,277],"isotyp":[77],"control-treated":[78],"target":[79],"set":[82],"1":[84],"each":[86,317],"individual":[87],"data":[88],"set.":[89],"No":[90],"statistically":[91],"significant":[92],"difference":[93],"(p=0.39":[94],"p=1,":[96],"respectively;":[97],"Mann-Whitney":[98],"U-Test)":[99],"observed":[101],"analysis":[103],"results":[105,325],"from":[106],"8":[107],"(cytotoxicity)":[108],"6":[110],"(cytokine":[111],"release)":[112],"independent":[113,174,179],"experiments.":[114],"(B)":[115],"Surface":[116],"levels":[117,255,304],"correlate":[122],"induction":[124],"Expression":[130],"on":[133],"patient":[134],"(circles)":[136],"CLL":[138],"(triangles)":[140],"correlated":[142],"calculated":[161],"described":[164],"A.":[166],"Each":[167],"symbol":[168],"represents":[169],"result":[171],"one":[173],"experiment.":[175],"number":[177],"experiments,":[180],"correlation":[181],"coefficients":[182],"(Pearson":[183],"correlation)":[184],"p":[186],"values":[187],"(T-Test)":[188],"are":[189],"indicated.":[190],"(C)":[191],"against":[194],"surface-negative":[196],"is":[199,326],"affected":[201],"fusion":[204,238],"proteins.":[205],"RPMI":[206],"8226":[207],"primary":[212],"lack":[217],"surface":[219],"expression":[220],"were":[221,258,269,307],"incubated":[222],"absence":[231,279],"10mug/ml":[233],"indicated":[236,289],"RANK":[237],"proteins":[239],"isotype":[241,283],"control.":[242],"Cytotoxicity":[243,293],"determined":[245,295],"2h":[247,297],"Europium":[248,298],"assays":[250,300],"(upper":[251],"panels)":[252],"IFN-gamma":[254],"supernatants":[257,306],"analyzed":[259,308],"after":[260,309],"24h":[261,310],"ELISA":[263,312],"(lower":[264],"panels).":[265],"(D)":[266],"transfectants":[268],"cultured":[270],"control":[284],"(10\ufffdg/ml":[285],"each)":[286],"concentrations":[290],"rRANKL.":[292],"IFN-\ufffd":[303],"(right).":[313],"One":[314],"repesentative":[315],"experiment":[316],"a":[319],"total":[320],"three":[322],"similar":[324],"shown":[327],"C":[329],"D.":[331]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}