{"id":"https://openalex.org/W4362403907","doi":"https://doi.org/10.1158/1078-0432.22465277","title":"Figure S1-S5 from Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP","display_name":"Figure S1-S5 from Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4362403907","doi":"https://doi.org/10.1158/1078-0432.22465277"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22465277","doi":"https://doi.org/10.1158/1078-0432.22465277","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22465277","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S1-S5_from_Acquired_Resistance_of_ER-Positive_Breast_Cancer_to_Endocrine_Treatment_Confers_an_Adaptive_Sensitivity_to_TRAIL_through_Posttranslational_Downregulation_of_c-FLIP/22465277/1/files/39916604.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S1-S5_from_Acquired_Resistance_of_ER-Positive_Breast_Cancer_to_Endocrine_Treatment_Confers_an_Adaptive_Sensitivity_to_TRAIL_through_Posttranslational_Downregulation_of_c-FLIP/22465277/1/files/39916604.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023545324","display_name":"Luke Piggott","orcid":"https://orcid.org/0000-0001-8602-2865","observed_orcids":["https://orcid.org/0000-0001-8602-2865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke Piggott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100600180","display_name":"Andreia Machado da Silva","orcid":"https://orcid.org/0000-0001-6365-1407","observed_orcids":["https://orcid.org/0000-0001-6365-1407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreia Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102107944","display_name":"Timothy Robinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy Robinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084823631","display_name":"Ang\u00e9lica Santiago-G\u00f3mez","orcid":"https://orcid.org/0000-0002-2946-2669","observed_orcids":["https://orcid.org/0000-0002-2946-2669"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angelica Santiago-G\u00f3mez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085631179","display_name":"Bruno M. Sim\u00f5es","orcid":"https://orcid.org/0000-0003-1253-6657","observed_orcids":["https://orcid.org/0000-0003-1253-6657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno M. Sim\u00f5es","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060122908","display_name":"Michael A. Becker","orcid":"https://orcid.org/0000-0002-9706-905X","observed_orcids":["https://orcid.org/0000-0002-9706-905X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Becker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109512554","display_name":"Iduna Fichtner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iduna Fichtner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082643230","display_name":"Ladislav And\u011bra","orcid":"https://orcid.org/0000-0003-3073-2280","observed_orcids":["https://orcid.org/0000-0003-3073-2280"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ladislav Andera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111891701","display_name":"Philippa Young","orcid":"https://orcid.org/0009-0006-9181-3753","observed_orcids":["https://orcid.org/0009-0006-9181-3753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philippa Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Christine Morris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Morris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003969811","display_name":"Peter J. Barrett-Lee","orcid":"https://orcid.org/0000-0002-6246-7357","observed_orcids":["https://orcid.org/0000-0002-6246-7357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Barrett-Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057403437","display_name":"Fouad Alchami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fouad Alchami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028758526","display_name":"Marco Piva","orcid":"https://orcid.org/0000-0001-6906-6065","observed_orcids":["https://orcid.org/0000-0001-6906-6065"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Piva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091309671","display_name":"Mar\u00eda dM Vivanco","orcid":"https://orcid.org/0000-0002-9540-247X","observed_orcids":["https://orcid.org/0000-0002-9540-247X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria dM. Vivanco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073495103","display_name":"Robert B. Clarke","orcid":"https://orcid.org/0000-0001-5407-3123","observed_orcids":["https://orcid.org/0000-0001-5407-3123","https://orcid.org/0000-0002-9278-0854"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert B. Clarke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012364827","display_name":"Julia M.W. Gee","orcid":"https://orcid.org/0000-0001-6483-2015","observed_orcids":["https://orcid.org/0000-0001-6483-2015"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Gee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070489186","display_name":"Richard W. E. Clarkson","orcid":"https://orcid.org/0000-0001-7389-8673","observed_orcids":["https://orcid.org/0000-0001-7389-8673"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Clarkson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.38040000200271606,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.38040000200271606,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.23270000517368317,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.16099999845027924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.8019999861717224},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/trail-sensitivity","display_name":"TRAIL sensitivity","score":0.871999979019165},{"id":"https://openalex.org/keywords/flip","display_name":"c-FLIP","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8489999771118164},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.7929480075836182},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.6441527605056763},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5802182555198669},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48031824827194214},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.47251543402671814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45824453234672546},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.45041322708129883},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42473727464675903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39547181129455566},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36593806743621826},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3466199040412903},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3426845371723175},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.329811692237854},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.22928619384765625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1143541932106018},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07558411359786987},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07516199350357056},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22465277","doi":"https://doi.org/10.1158/1078-0432.22465277","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22465277","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S1-S5_from_Acquired_Resistance_of_ER-Positive_Breast_Cancer_to_Endocrine_Treatment_Confers_an_Adaptive_Sensitivity_to_TRAIL_through_Posttranslational_Downregulation_of_c-FLIP/22465277/1/files/39916604.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22465277","doi":"https://doi.org/10.1158/1078-0432.22465277","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22465277","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S1-S5_from_Acquired_Resistance_of_ER-Positive_Breast_Cancer_to_Endocrine_Treatment_Confers_an_Adaptive_Sensitivity_to_TRAIL_through_Posttranslational_Downregulation_of_c-FLIP/22465277/1/files/39916604.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362403907.pdf","grobid_xml":"https://content.openalex.org/works/W4362403907.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361945972","https://openalex.org/W2800004342","https://openalex.org/W1975378908","https://openalex.org/W2797593820","https://openalex.org/W2206774775","https://openalex.org/W1669037042","https://openalex.org/W1549256608","https://openalex.org/W3171499407","https://openalex.org/W3176472161","https://openalex.org/W3176258634"],"abstract_inverted_index":{"Figure":[0,9,17,22,34],"S1:":[1],"Endocrine-resistant":[2,11,24],"MCF-7":[3],"cells":[4,29],"demonstrate":[5,13],"sensitivity":[6,14,41],"to":[7,15,32,42],"TRAIL":[8],"S2:":[10],"CSCs":[12],"TRIAL.":[16],"S3:":[18],"Primary-derived":[19],"patient":[20],"samples.":[21],"S4:":[23],"primary":[25],"and":[26],"PDX":[27],"tumour":[28,39],"are":[30],"sensitive":[31],"TRAIL.":[33,43],"S5:":[35],"Mechanism":[36],"of":[37],"endocrine-resistant":[38],"cell":[40]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2023-04-05T00:00:00"}
