{"id":"https://openalex.org/W4362394837","doi":"https://doi.org/10.1158/1078-0432.22448670","title":"Supplementary Table 1 from Modeling RAS Phenotype in Colorectal Cancer Uncovers Novel Molecular Traits of RAS Dependency and Improves Prediction of Response to Targeted Agents in Patients","display_name":"Supplementary Table 1 from Modeling RAS Phenotype in Colorectal Cancer Uncovers Novel Molecular Traits of RAS Dependency and Improves Prediction of Response to Targeted Agents in Patients","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4362394837","doi":"https://doi.org/10.1158/1078-0432.22448670"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22448670","doi":"https://doi.org/10.1158/1078-0432.22448670","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22448670","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_1_from_Modeling_RAS_Phenotype_in_Colorectal_Cancer_Uncovers_Novel_Molecular_Traits_of_RAS_Dependency_and_Improves_Prediction_of_Response_to_Targeted_Agents_in_Patients/22448670/1/files/39899721.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_1_from_Modeling_RAS_Phenotype_in_Colorectal_Cancer_Uncovers_Novel_Molecular_Traits_of_RAS_Dependency_and_Improves_Prediction_of_Response_to_Targeted_Agents_in_Patients/22448670/1/files/39899721.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080308005","display_name":"Justin Guinney","orcid":"https://orcid.org/0000-0003-1477-1888","observed_orcids":["https://orcid.org/0000-0003-1477-1888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin Guinney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111883100","display_name":"Charles Fert\u00e9","orcid":"https://orcid.org/0000-0001-5701-8357","observed_orcids":["https://orcid.org/0000-0001-5701-8357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Fert\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063585604","display_name":"Jonathan R. Dry","orcid":"https://orcid.org/0000-0002-1640-2616","observed_orcids":["https://orcid.org/0000-0002-1640-2616"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Dry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009167161","display_name":"Robert K. McEwen","orcid":"https://orcid.org/0009-0000-7155-5714","observed_orcids":["https://orcid.org/0009-0000-7155-5714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert McEwen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044673409","display_name":"Gilles Manceau","orcid":"https://orcid.org/0000-0002-0783-8688","observed_orcids":["https://orcid.org/0000-0002-0783-8688"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilles Manceau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967164","display_name":"KJ Kao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KJ Kao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102889840","display_name":"Kai\u2010Ming Chang","orcid":"https://orcid.org/0000-0003-3911-8463","observed_orcids":["https://orcid.org/0000-0003-3911-8463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai-Ming Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047570415","display_name":"Claus Bendtsen","orcid":"https://orcid.org/0000-0002-8338-987X","observed_orcids":["https://orcid.org/0000-0002-8338-987X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claus Bendtsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061297807","display_name":"Kevin Hudson","orcid":"https://orcid.org/0000-0002-6608-891X","observed_orcids":["https://orcid.org/0000-0002-6608-891X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Hudson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104092030","display_name":"Erich S. Huang","orcid":"https://orcid.org/0000-0001-5547-9408","observed_orcids":["https://orcid.org/0000-0001-5547-9408"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erich Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087646089","display_name":"Brian Andrew Dougherty","orcid":"https://orcid.org/0000-0002-0093-1142","observed_orcids":["https://orcid.org/0000-0002-0093-1142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Dougherty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085121407","display_name":"Michel Pierre Ducreux","orcid":"https://orcid.org/0000-0001-8649-7449","observed_orcids":["https://orcid.org/0000-0001-8649-7449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michel Ducreux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021624793","display_name":"Jean\u2010Charles Soria","orcid":"https://orcid.org/0000-0001-9597-0701","observed_orcids":["https://orcid.org/0000-0001-9597-0701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Charles Soria","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069348884","display_name":"Stephen Henry Friend","orcid":"https://orcid.org/0000-0002-0830-7600","observed_orcids":["https://orcid.org/0000-0002-0830-7600"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Friend","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074057226","display_name":"Jonathan M.J. Derry","orcid":"https://orcid.org/0009-0005-7620-0003","observed_orcids":["https://orcid.org/0009-0005-7620-0003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Derry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089818289","display_name":"Pierre Laurent\u2010Puig","orcid":"https://orcid.org/0000-0001-8475-5459","observed_orcids":["https://orcid.org/0000-0001-8475-5459"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Laurent-Puig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.7720000147819519},{"id":"https://openalex.org/keywords/targeted-therapy-response-prediction","display_name":"targeted therapy response prediction","score":0.7990000247955322},{"id":"https://openalex.org/keywords/molecular-traits","display_name":"molecular traits","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C19768560","wikidata":"https://www.wikidata.org/wiki/Q320727","display_name":"Dependency (UML)","level":2,"score":0.803516149520874},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7072027325630188},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.5640079379081726},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5629453063011169},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49504604935646057},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40926092863082886},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33669835329055786},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33618780970573425},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33103886246681213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32822656631469727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3087735176086426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2785085439682007},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13406771421432495},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1327148675918579},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.10537528991699219}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22448670","doi":"https://doi.org/10.1158/1078-0432.22448670","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22448670","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_1_from_Modeling_RAS_Phenotype_in_Colorectal_Cancer_Uncovers_Novel_Molecular_Traits_of_RAS_Dependency_and_Improves_Prediction_of_Response_to_Targeted_Agents_in_Patients/22448670/1/files/39899721.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22448670","doi":"https://doi.org/10.1158/1078-0432.22448670","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22448670","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_1_from_Modeling_RAS_Phenotype_in_Colorectal_Cancer_Uncovers_Novel_Molecular_Traits_of_RAS_Dependency_and_Improves_Prediction_of_Response_to_Targeted_Agents_in_Patients/22448670/1/files/39899721.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362394837.pdf","grobid_xml":"https://content.openalex.org/works/W4362394837.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361944518","https://openalex.org/W2116200229","https://openalex.org/W2079545401","https://openalex.org/W2493308654","https://openalex.org/W4310754362","https://openalex.org/W4415940830","https://openalex.org/W4313008929","https://openalex.org/W2886257579","https://openalex.org/W4394970939","https://openalex.org/W4282968795"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"37K,":[3],"Characteristics":[4],"of":[5,16],"the":[6,17],"4":[7],"CRC":[8],"datasets":[9],"used":[10],"in":[11],"training":[12],"(KFSYSCC)":[13],"and":[14],"validation":[15],"RAS":[18],"model.":[19]},"counts_by_year":[],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2023-04-05T00:00:00"}