{"id":"https://openalex.org/W4362394444","doi":"https://doi.org/10.1158/1078-0432.22446698","title":"Supplementary Figure 5 from An Epithelial\u2013Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance","display_name":"Supplementary Figure 5 from An Epithelial\u2013Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4362394444","doi":"https://doi.org/10.1158/1078-0432.22446698"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22446698","doi":"https://doi.org/10.1158/1078-0432.22446698","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22446698","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.22446698","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067755477","display_name":"Lauren A. Byers","orcid":"https://orcid.org/0000-0002-0780-2677","observed_orcids":["https://orcid.org/0000-0002-0780-2677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauren Averett Byers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089771018","display_name":"Lixia Diao","orcid":"https://orcid.org/0000-0001-6995-4492","observed_orcids":["https://orcid.org/0000-0001-6995-4492"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lixia Diao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378341","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0001-7199-4784","observed_orcids":["https://orcid.org/0000-0001-7199-4784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065373099","display_name":"Pierre Saintigny","orcid":"https://orcid.org/0000-0002-8090-9323","observed_orcids":["https://orcid.org/0000-0002-8090-9323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Saintigny","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023932021","display_name":"Luc Girard","orcid":"https://orcid.org/0000-0002-6688-5281","observed_orcids":["https://orcid.org/0000-0002-6688-5281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luc Girard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010128828","display_name":"Michael Peyton","orcid":"https://orcid.org/0009-0002-4170-9633","observed_orcids":["https://orcid.org/0009-0002-4170-9633"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Peyton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110445","display_name":"Li Shen","orcid":"https://orcid.org/0000-0001-8427-9448","observed_orcids":["https://orcid.org/0000-0001-8427-9448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100551714","display_name":"Youhong Fan","orcid":"https://orcid.org/0000-0001-9990-3258","observed_orcids":["https://orcid.org/0000-0001-9990-3258"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youhong Fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059903431","display_name":"Uma P. Giri","orcid":"https://orcid.org/0000-0001-9529-3173","observed_orcids":["https://orcid.org/0000-0001-9529-3173"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uma Giri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014869813","display_name":"Praveen Kumar Tumula","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Praveen K. Tumula","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040693824","display_name":"Monique B. Nilsson","orcid":"https://orcid.org/0000-0002-0975-8833","observed_orcids":["https://orcid.org/0000-0002-0975-8833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monique B. Nilsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074180677","display_name":"Jayanthi P. Gudikote","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jayanthi Gudikote","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056267838","display_name":"Hai Thanh Tran","orcid":"https://orcid.org/0000-0003-4065-9355","observed_orcids":["https://orcid.org/0000-0003-4065-9355"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai Tran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067497387","display_name":"Robert J. Cardnell","orcid":"https://orcid.org/0009-0005-6203-0234","observed_orcids":["https://orcid.org/0009-0005-6203-0234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert J.G. Cardnell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037979147","display_name":"David J. Bearss","orcid":"https://orcid.org/0000-0003-4940-9942","observed_orcids":["https://orcid.org/0000-0003-4940-9942"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J. Bearss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055924314","display_name":"Steven L. Warner","orcid":"https://orcid.org/0000-0002-6596-1676","observed_orcids":["https://orcid.org/0000-0002-6596-1676"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven L. Warner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065834685","display_name":"Jason M. Foulks","orcid":"https://orcid.org/0000-0002-7883-2347","observed_orcids":["https://orcid.org/0000-0002-7883-2347"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason M. Foulks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084399396","display_name":"Steven Brian Kanner","orcid":"https://orcid.org/0000-0002-7698-9113","observed_orcids":["https://orcid.org/0000-0002-7698-9113","https://orcid.org/0009-0003-7790-4307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven B. Kanner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024454882","display_name":"Varsha V. Gandhi","orcid":"https://orcid.org/0000-0002-3172-9166","observed_orcids":["https://orcid.org/0000-0002-3172-9166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Varsha Gandhi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001354914","display_name":"Nancy\u2005L. Krett","orcid":"https://orcid.org/0000-0001-8329-4830","observed_orcids":["https://orcid.org/0000-0001-8329-4830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy Krett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013430443","display_name":"Steven T. Rosen","orcid":"https://orcid.org/0000-0002-8818-7724","observed_orcids":["https://orcid.org/0000-0002-8818-7724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven T. Rosen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067386747","display_name":"Edward S. Kim","orcid":"https://orcid.org/0000-0001-8351-1196","observed_orcids":["https://orcid.org/0000-0001-8351-1196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward S. Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008593691","display_name":"Roy S. Herbst","orcid":"https://orcid.org/0000-0003-2535-5847","observed_orcids":["https://orcid.org/0000-0003-2535-5847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roy S. Herbst","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077579849","display_name":"George R. Blumenschein","orcid":"https://orcid.org/0000-0002-9606-8194","observed_orcids":["https://orcid.org/0000-0002-9606-8194"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George R. Blumenschein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083735812","display_name":"J. Jack Lee","orcid":"https://orcid.org/0009-0005-4475-8299","observed_orcids":["https://orcid.org/0009-0005-4475-8299"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Jack Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069190968","display_name":"Scott Michael Lippman","orcid":"https://orcid.org/0000-0002-1643-4124","observed_orcids":["https://orcid.org/0000-0002-1643-4124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott M. Lippman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049318043","display_name":"K. Kian Ang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Kian Ang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111144617","display_name":"Waun Ki Hong","orcid":"https://orcid.org/0009-0008-9329-5544","observed_orcids":["https://orcid.org/0009-0008-9329-5544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Waun K. Hong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026079862","display_name":"John N. Weinstein","orcid":"https://orcid.org/0000-0001-9401-6908","observed_orcids":["https://orcid.org/0000-0001-9401-6908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John N. Weinstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028085268","display_name":"Ignacio Ivan Wistuba","orcid":"https://orcid.org/0000-0003-3365-6340","observed_orcids":["https://orcid.org/0000-0003-3365-6340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ignacio I. Wistuba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066837969","display_name":"Kevin R. Coombes","orcid":"https://orcid.org/0000-0002-7630-2123","observed_orcids":["https://orcid.org/0000-0002-7630-2123"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin R. Coombes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048865240","display_name":"John Dorrance Minna","orcid":"https://orcid.org/0000-0002-7776-0767","observed_orcids":["https://orcid.org/0000-0002-7776-0767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John D. Minna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048380048","display_name":"John Victor Heymach","orcid":"https://orcid.org/0000-0001-9068-8942","observed_orcids":["https://orcid.org/0000-0001-9068-8942"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John V. Heymach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.35740000009536743,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.35740000009536743,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.34279999136924744,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.14249999821186066,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.8190000057220459},{"id":"https://openalex.org/keywords/egfr-inhibitor-resistance","display_name":"EGFR inhibitor resistance","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pi3k-inhibitor-resistance","display_name":"PI3K inhibitor resistance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/axl","display_name":"AXL","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mesenchymal-cells","display_name":"mesenchymal cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6269999742507935},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.6934477686882019},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5493450164794922},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.5375096201896667},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.5313815474510193},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4386410117149353},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.41357243061065674},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35996419191360474},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3558273911476135},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.2991796135902405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2883946895599365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2696110010147095},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14936906099319458},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13930097222328186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09761714935302734},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09132695198059082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0593474805355072},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22446698","doi":"https://doi.org/10.1158/1078-0432.22446698","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22446698","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22446698","doi":"https://doi.org/10.1158/1078-0432.22446698","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22446698","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1006589974","https://openalex.org/W1974250949","https://openalex.org/W2031281657","https://openalex.org/W1978608178","https://openalex.org/W155856152","https://openalex.org/W2898511335","https://openalex.org/W3188367623","https://openalex.org/W4220837694","https://openalex.org/W4385441962","https://openalex.org/W4362394508"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"50K,":[3],"Mesenchymal":[4],"lines":[5],"are":[6],"sensitive":[7],"to":[8],"Axl":[9],"inhibition":[10],"by":[11],"SGI-7079":[12]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}