{"id":"https://openalex.org/W4362393620","doi":"https://doi.org/10.1158/1078-0432.22445036","title":"Supplementary Figures 1 - 8 from Lyn Kinase Mediates Cell Motility and Tumor Growth in EGFRvIII-Expressing Head and Neck Cancer","display_name":"Supplementary Figures 1 - 8 from Lyn Kinase Mediates Cell Motility and Tumor Growth in EGFRvIII-Expressing Head and Neck Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4362393620","doi":"https://doi.org/10.1158/1078-0432.22445036"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22445036","doi":"https://doi.org/10.1158/1078-0432.22445036","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22445036","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22445036","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010717116","display_name":"Sarah E. Wheeler","orcid":"https://orcid.org/0000-0002-6547-8860","observed_orcids":["https://orcid.org/0000-0002-6547-8860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah E. Wheeler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037107538","display_name":"Elena M. Morariu","orcid":"https://orcid.org/0000-0002-8753-5280","observed_orcids":["https://orcid.org/0000-0002-8753-5280"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena M. Morariu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007786518","display_name":"Joseph S. Bednash","orcid":"https://orcid.org/0000-0003-3576-4388","observed_orcids":["https://orcid.org/0000-0003-3576-4388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph S. Bednash","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067364227","display_name":"Charlton G. Otte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charlton G. Otte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056955251","display_name":"Raja R. Seethala","orcid":"https://orcid.org/0000-0003-3617-075X","observed_orcids":["https://orcid.org/0000-0003-3617-075X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raja R. Seethala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073112024","display_name":"Simion I. Chiosea","orcid":"https://orcid.org/0000-0002-5766-8779","observed_orcids":["https://orcid.org/0000-0002-5766-8779"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simion I. Chiosea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088286120","display_name":"Jennifer Rubin Grandis","orcid":"https://orcid.org/0000-0002-1013-8965","observed_orcids":["https://orcid.org/0000-0002-1013-8965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer R. Grandis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lyn-kinase","display_name":"Lyn kinase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/egfrviii","display_name":"EGFRvIII","score":0.9950000047683716},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8790000081062317},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8109999895095825},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.8610000014305115},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C175818844","wikidata":"https://www.wikidata.org/wiki/Q2463389","display_name":"LYN","level":4,"score":0.9579485058784485},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.816622257232666},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7448017001152039},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6864404678344727},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4944019317626953},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4833926260471344},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4810900390148163},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4737490117549896},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.30445733666419983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2768726646900177},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21025091409683228},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.16697952151298523},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.16175305843353271},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05353045463562012},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22445036","doi":"https://doi.org/10.1158/1078-0432.22445036","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22445036","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22445036.v1","doi":"https://doi.org/10.1158/1078-0432.22445036.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22445036.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39896084","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22445036","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figures_1_-_8_from_Lyn_Kinase_Mediates_Cell_Motility_and_Tumor_Growth_in_EGFRvIII-Expressing_Head_and_Neck_Cancer/22445036","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22445036","doi":"https://doi.org/10.1158/1078-0432.22445036","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22445036","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362393620.pdf","grobid_xml":"https://content.openalex.org/works/W4362393620.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361950143","https://openalex.org/W2163154356","https://openalex.org/W1995828194","https://openalex.org/W2124254102","https://openalex.org/W4392684053","https://openalex.org/W2082454341","https://openalex.org/W2171411676","https://openalex.org/W6977008895","https://openalex.org/W3190322609","https://openalex.org/W2328727283"],"abstract_inverted_index":{"PDF":[0],"file,":[1],"1038KB,":[2],"S1:":[3],"Dasatinib":[4,25],"treatment":[5],"decreases":[6],"migration":[7,69,85],"and":[8,18,70,86],"invasion":[9],"in":[10,16,29,37,46,49],"EGFRvIII":[11,30],"expressing":[12,31],"HNSCC.":[13],"S2:STAT3":[14],"expression":[15],"dasatinib":[17],"Lyn":[19,35,47,59,65,75],"siRNA":[20,60,79],"treated":[21],"HNSCC":[22,39,54,68,84],"cells.":[23,43],"S3:":[24],"inhibits":[26,66],"tumor":[27],"growth":[28],"xenografts.":[32],"S4:":[33],"Increased":[34],"phosphorylation":[36,48],"EGFRvIII-expressing":[38],"compared":[40],"to":[41],"vector-control":[42],"S5:":[44],"Increase":[45],"three":[50],"separate":[51],"clones":[52],"of":[53,64,74,82],"cell":[55],"lines":[56],"Cal33.":[57],"S6:":[58],"specificity.":[61],"S7:":[62],"Knockdown":[63,73],"EGFRvIII-mediated":[67,83],"invasion.":[71,87],"S8:":[72],"with":[76],"a":[77],"second":[78],"confirms":[80],"inhibition":[81]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
