{"id":"https://openalex.org/W4362292064","doi":"https://doi.org/10.1158/0008-5472.22405982","title":"Supplementary Figure S2 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer","display_name":"Supplementary Figure S2 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4362292064","doi":"https://doi.org/10.1158/0008-5472.22405982"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22405982","doi":"https://doi.org/10.1158/0008-5472.22405982","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22405982","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22405982","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085778676","display_name":"Carmen Priolo","orcid":"https://orcid.org/0000-0001-5716-3642","observed_orcids":["https://orcid.org/0000-0001-5716-3642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Priolo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044355098","display_name":"Saumyadipta Pyne","orcid":"https://orcid.org/0000-0003-3470-2345","observed_orcids":["https://orcid.org/0000-0003-3470-2345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saumyadipta Pyne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112214564","display_name":"Joshua Rose","orcid":"https://orcid.org/0009-0001-4425-0656","observed_orcids":["https://orcid.org/0009-0001-4425-0656"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joshua Rose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007285525","display_name":"Erzs\u00e9bet Ravasz Regan","orcid":"https://orcid.org/0000-0002-8663-3153","observed_orcids":["https://orcid.org/0000-0002-8663-3153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erzs\u00e9bet Ravasz Regan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040491062","display_name":"Giorgia Zadra","orcid":"https://orcid.org/0000-0002-8123-1358","observed_orcids":["https://orcid.org/0000-0002-8123-1358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgia Zadra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043087111","display_name":"Cornelia Photopoulos","orcid":"https://orcid.org/0009-0005-9068-3769","observed_orcids":["https://orcid.org/0009-0005-9068-3769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cornelia Photopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021055966","display_name":"Stefano Cacciatore","orcid":"https://orcid.org/0000-0001-7052-7156","observed_orcids":["https://orcid.org/0000-0001-7052-7156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefano Cacciatore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071904198","display_name":"Denise Schultz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denise Schultz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074321198","display_name":"Natalia Scaglia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia Scaglia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024316774","display_name":"Jonathan E. McDunn","orcid":"https://orcid.org/0000-0001-8792-828X","observed_orcids":["https://orcid.org/0000-0001-8792-828X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan McDunn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083333223","display_name":"Angelo Michael De Marzo","orcid":"https://orcid.org/0000-0003-4847-5307","observed_orcids":["https://orcid.org/0000-0003-4847-5307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angelo M. De Marzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071763026","display_name":"Massimo F. Loda","orcid":"https://orcid.org/0000-0001-9674-8379","observed_orcids":["https://orcid.org/0000-0001-9674-8379"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimo Loda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.06080000102519989,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/glycolysis-metabolites","display_name":"glycolysis metabolites","score":0.9430000185966492},{"id":"https://openalex.org/keywords/rwpe-1-cells","display_name":"RWPE-1 cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/genetically-modified-mice","display_name":"genetically modified mice","score":0.7139999866485596},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.5899999737739563},{"id":"https://openalex.org/keywords/metabolic-fingerprint","display_name":"metabolic fingerprint","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6220950484275818},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.5525693893432617},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5359599590301514},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.47749611735343933},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.4300042986869812},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4101659655570984},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3927575349807739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34538424015045166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29593324661254883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.248274564743042},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.23970580101013184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23668089509010315},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2073739469051361}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.22405982","doi":"https://doi.org/10.1158/0008-5472.22405982","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22405982","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22405982.v1","doi":"https://doi.org/10.1158/0008-5472.22405982.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22405982.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22405982","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/software/Supplementary_Figure_S2_from_AKT1_and_MYC_Induce_Distinctive_Metabolic_Fingerprints_in_Human_Prostate_Cancer/22405982","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Software"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22405982","doi":"https://doi.org/10.1158/0008-5472.22405982","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22405982","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392687605","https://openalex.org/W2077058200","https://openalex.org/W3170918810","https://openalex.org/W1870480401","https://openalex.org/W2894625640","https://openalex.org/W2321633425","https://openalex.org/W2965406290","https://openalex.org/W4362624355","https://openalex.org/W6902262539","https://openalex.org/W2166487880"],"abstract_inverted_index":{"Concentration":[0],"of":[1,43,45,60],"glycolysis":[2],"metabolites":[3,44],"(A)":[4],"in":[5,27,31,37,49],"genetically":[6],"engineered":[7],"RWPE-1":[8],"cells":[9],"and":[10,12,21,33,41,54],"mice,":[11],"human":[13],"prostate":[14,23],"tissue":[15],"samples.":[16],"Controls":[17],"(RWPE-EV,":[18],"WT":[19,50],"mice":[20],"normal":[22],"samples)":[24],"are":[25,36],"represented":[26],"blue,":[28],"phosphoAKT1-high":[29],"samples":[30,35],"orange":[32],"MYC-high":[34],"green.":[38],"(B)":[39],"Diagram":[40],"concentration":[42],"the":[46],"glycine/sarcosine":[47],"pathway":[48],"(blue),":[51],"MPAKT":[52],"(orange)":[53],"Lo-MYC":[55],"(green)":[56],"mice.":[57],"One-way":[58],"analysis":[59],"variance":[61],"(ANOVA)":[62],"followed":[63],"by":[64],"Tukey's":[65],"Multiple":[66],"Comparison":[67],"Test":[68],"was":[69],"performed":[70],"using":[71],"post-normalization":[72],"metabolite":[73],"quantities.":[74]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}