{"id":"https://openalex.org/W4362207794","doi":"https://doi.org/10.14283/jpad.2023.37","title":"Association of Circulating Caprylic Acid with Risk of Mild Cognitive Impairment and Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Cohort","display_name":"Association of Circulating Caprylic Acid with Risk of Mild Cognitive Impairment and Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Cohort","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4362207794","doi":"https://doi.org/10.14283/jpad.2023.37","pmid":"https://pubmed.ncbi.nlm.nih.gov/37357292"},"language":"en","primary_location":{"id":"doi:10.14283/jpad.2023.37","doi":"https://doi.org/10.14283/jpad.2023.37","is_oa":true,"landing_page_url":"https://doi.org/10.14283/jpad.2023.37","pdf_url":null,"source":{"id":"https://openalex.org/S4210234663","display_name":"The Journal of Prevention of Alzheimer s Disease","issn_l":"2274-5807","issn":["2274-5807","2426-0266"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Prevention of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.14283/jpad.2023.37","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"L. Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Fan","raw_affiliation_strings":["Qi Dai, M.D., Ph.D., Department of Medicine, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 800, Nashville, TN 37203-1738, USA, Phone: (615) 936-0707, Fax: (615) 343-5938, E-mail: qi.dai@vanderbilt.edu","Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qi Dai, M.D., Ph.D., Department of Medicine, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 800, Nashville, TN 37203-1738, USA, Phone: (615) 936-0707, Fax: (615) 343-5938, E-mail: qi.dai@vanderbilt.edu","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007901857","display_name":"Xiaogdong Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Zhu","raw_affiliation_strings":["Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA","Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000053375","display_name":"Amy R. Borenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.R. Borenstein","raw_affiliation_strings":["Division of Epidemiology, Herbert Wertheim School of Public Health and Human Longevity Science, University of California-San Diego, La Jolla, CA, USA","Division of Epidemiology, Herbert Wertheim School of Public Health and Human Longevity Science, University of California-San Diego, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Herbert Wertheim School of Public Health and Human Longevity Science, University of California-San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Epidemiology, Herbert Wertheim School of Public Health and Human Longevity Science, University of California-San Diego, La Jolla, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057648011","display_name":"Xiang Huang","orcid":"https://orcid.org/0000-0003-0180-103X","observed_orcids":["https://orcid.org/0000-0003-0180-103X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Huang","raw_affiliation_strings":["Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA","Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056193431","display_name":"Martha J. Shrubsole","orcid":"https://orcid.org/0000-0002-5591-7575","observed_orcids":["https://orcid.org/0000-0002-5591-7575"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.J. Shrubsole","raw_affiliation_strings":["Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA","Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085969135","display_name":"Laura L. Dugan","orcid":"https://orcid.org/0000-0003-2269-6726","observed_orcids":["https://orcid.org/0000-0003-2269-6726"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.L. Dugan","raw_affiliation_strings":["Division of Geriatric Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","VA Tennessee Valley Geriatric Research, Education, and Clinical Center (GRECC), Nashville, TN, USA","Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA","Division of Geriatric Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA","VA Tennessee Valley Geriatric Research, Education, and Clinical Center (GRECC), Nashville, USA","Vanderbilt Brain Institute, Vanderbilt University, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatric Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"VA Tennessee Valley Geriatric Research, Education, and Clinical Center (GRECC), Nashville, TN, USA","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Division of Geriatric Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"VA Tennessee Valley Geriatric Research, Education, and Clinical Center (GRECC), Nashville, USA","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Brain Institute, Vanderbilt University, Nashville, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100661482","display_name":"Qi Dai","orcid":"https://orcid.org/0000-0003-1343-1494","observed_orcids":["https://orcid.org/0000-0003-1343-1494"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qi Dai","raw_affiliation_strings":["Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA","Department of Medicine, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 800, Nashville, TN, 37203-1738, USA","Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 800, Nashville, TN, 37203-1738, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100661482"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":1.441,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.80172433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"3","first_page":"513","last_page":"522"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/octanoic-acid","display_name":"octanoic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/medium-chain-fatty-acids","display_name":"medium-chain fatty acids","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9039999842643738},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cardiometabolic-disease","display_name":"cardiometabolic disease","score":0.6639999747276306},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.9269999861717224},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cognitively-normal-older-adults","display_name":"cognitively normal older adults","score":0.8019999861717224},{"id":"https://openalex.org/keywords/alzheimer-s-disease-prevention","display_name":"Alzheimer's disease prevention","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6894209980964661},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6883512139320374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.627291202545166},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5850015878677368},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.5796757936477661},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5757294297218323},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.48072198033332825},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.46134549379348755},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45467692613601685},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.4478951394557953},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4187217652797699},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.41561371088027954}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D002210","descriptor_name":"Caprylates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002210","descriptor_name":"Caprylates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002210","descriptor_name":"Caprylates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002210","descriptor_name":"Caprylates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.14283/jpad.2023.37","doi":"https://doi.org/10.14283/jpad.2023.37","is_oa":true,"landing_page_url":"https://doi.org/10.14283/jpad.2023.37","pdf_url":null,"source":{"id":"https://openalex.org/S4210234663","display_name":"The Journal of Prevention of Alzheimer s Disease","issn_l":"2274-5807","issn":["2274-5807","2426-0266"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Prevention of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:37357292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37357292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of prevention of Alzheimer's disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10442865","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10442865","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10442865/pdf/nihms-1922108.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Prev Alzheimers Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.14283/jpad.2023.37","doi":"https://doi.org/10.14283/jpad.2023.37","is_oa":true,"landing_page_url":"https://doi.org/10.14283/jpad.2023.37","pdf_url":null,"source":{"id":"https://openalex.org/S4210234663","display_name":"The Journal of Prevention of Alzheimer s Disease","issn_l":"2274-5807","issn":["2274-5807","2426-0266"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Prevention of Alzheimer's Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.4099999964237213}],"study_designs":[],"awards":[{"id":"https://openalex.org/G104586243","display_name":null,"funder_award_id":"U01-AG-024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2189010064","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G2423387114","display_name":null,"funder_award_id":"W81XWH-12-2\u20130012","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G2835601961","display_name":null,"funder_award_id":"U01AG024904","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G29951154","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G3216574877","display_name":null,"funder_award_id":"W81XWH-12-2-","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G421370006","display_name":null,"funder_award_id":"R01 DK110166","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4392045102","display_name":null,"funder_award_id":"R01 AG058856","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4475667458","display_name":null,"funder_award_id":"W81XWH-12-2-","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4716992166","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320337376","funder_display_name":"NIH Clinical Center"},{"id":"https://openalex.org/G5381939979","display_name":"EFFECTS OF TRAUMATIC BRAIN INJURY (TBI) AND POST TRAUMATIC STRESS DISORDER (PTSD) ON ALZHEIMER'S DISEASE (AD) IN VETERANS USING IMAGING AND BIOMARKERS IN THE AD NEUROIMAGING INITIATIVE (ADNI)\"","funder_award_id":"W81XWH1220012","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G764699806","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8895907669","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G9000039018","display_name":null,"funder_award_id":"U01-AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000122335","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G960790097","display_name":null,"funder_award_id":"R01AG033679","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320309697","display_name":"Alzheimer's Disease Neuroimaging Initiative","ror":"https://ror.org/01j20wc74"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334047","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1526060982","https://openalex.org/W1543068333","https://openalex.org/W1901948746","https://openalex.org/W1938773032","https://openalex.org/W1994856266","https://openalex.org/W1995630908","https://openalex.org/W2010138688","https://openalex.org/W2016115703","https://openalex.org/W2024671481","https://openalex.org/W2024748283","https://openalex.org/W2028911700","https://openalex.org/W2031148567","https://openalex.org/W2041522910","https://openalex.org/W2042679795","https://openalex.org/W2043595793","https://openalex.org/W2045141662","https://openalex.org/W2057719245","https://openalex.org/W2059198479","https://openalex.org/W2062452059","https://openalex.org/W2079938040","https://openalex.org/W2087040730","https://openalex.org/W2098787760","https://openalex.org/W2101042964","https://openalex.org/W2101304481","https://openalex.org/W2107199945","https://openalex.org/W2125993125","https://openalex.org/W2150027640","https://openalex.org/W2152072449","https://openalex.org/W2164303459","https://openalex.org/W2168854431","https://openalex.org/W2181121996","https://openalex.org/W2238829543","https://openalex.org/W2279204677","https://openalex.org/W2341340846","https://openalex.org/W2460959997","https://openalex.org/W2471638006","https://openalex.org/W2498795028","https://openalex.org/W2600906879","https://openalex.org/W2601368841","https://openalex.org/W2610257065","https://openalex.org/W2613799776","https://openalex.org/W2626736239","https://openalex.org/W2758712257","https://openalex.org/W2765164306","https://openalex.org/W2765822692","https://openalex.org/W2772361019","https://openalex.org/W2774052104","https://openalex.org/W2791596380","https://openalex.org/W2791994509","https://openalex.org/W2794227656","https://openalex.org/W2891082978","https://openalex.org/W2901044913","https://openalex.org/W2910859275","https://openalex.org/W2916038779","https://openalex.org/W2941655008","https://openalex.org/W2968800973","https://openalex.org/W2981873508","https://openalex.org/W2995325013","https://openalex.org/W2999771355","https://openalex.org/W2999936081","https://openalex.org/W3037825820","https://openalex.org/W3131138771","https://openalex.org/W3162450701","https://openalex.org/W3182833340","https://openalex.org/W3193613799","https://openalex.org/W3202637977","https://openalex.org/W4211050998","https://openalex.org/W4211238543","https://openalex.org/W4295242401","https://openalex.org/W4400802330","https://openalex.org/W6640649486","https://openalex.org/W6682395547"],"related_works":["https://openalex.org/W2162951066","https://openalex.org/W3003860558","https://openalex.org/W2987433916","https://openalex.org/W2082002278","https://openalex.org/W313460363","https://openalex.org/W4214932237","https://openalex.org/W25163377","https://openalex.org/W2018066652","https://openalex.org/W2017059429","https://openalex.org/W2959125974"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Medium-chain":[1],"fatty":[2],"acids":[3],"(MCFAs)":[4],"can":[5],"rapidly":[6],"cross":[7],"the":[8,18,78,190],"blood-brain":[9],"barrier":[10],"and":[11,47,56,73,109,115,128,145,186],"provide":[12],"an":[13],"alternative":[14],"energy":[15],"source":[16],"for":[17,198],"brain.":[19],"This":[20],"study":[21],"aims":[22],"to":[23,97,104],"determine":[24],"1)":[25],"whether":[26,58],"plasma":[27,85],"caprylic":[28],"acid":[29],"(C8:0)":[30],"is":[31],"associated":[32],"with":[33,112,155,166,217],"risk":[34,129,146],"of":[35,65,130,134,143,147,169,210,241],"incident":[36,48,113,131,148],"mild":[37],"cognitive":[38],"impairment":[39],"(MCI)":[40],"among":[41,52,152,208,246],"baseline":[42,53,90],"cognitively":[43],"normal":[44],"(CN)":[45],"participants,":[46,212],"Alzheimer's":[49,79],"Disease":[50,80],"(AD)":[51],"MCI":[54,114,132,149],"participants;":[55],"2)":[57],"these":[59],"associations":[60,204],"differ":[61],"by":[62],"sex,":[63],"comorbidity":[64],"cardiometabolic":[66,157,221],"diseases,":[67,222],"apolipoprotein":[68],"E":[69],"(APOE)":[70],"\u03b54":[71,171,226],"alleles,":[72],"ADAS-Cog":[74,187,230],"13.":[75],"METHODS:":[76],"Within":[77],"Neuroimaging":[81],"Initiative":[82],"(ADNI)":[83],"cohort,":[84],"C8:0":[86,127,144],"was":[87,133,150],"measured":[88],"at":[89],"in":[91,243],"618":[92],"AD-free":[93],"participants":[94,154],"aged":[95],"55":[96],"91.":[98],"Logistic":[99],"regression":[100],"models":[101],"were":[102,205],"used":[103],"estimate":[105],"odds":[106],"ratios":[107],"(ORs)":[108],"95%":[110],"CIs":[111],"AD":[116,245],"as":[117],"dependent":[118],"variables,":[119],"separately.":[120],"RESULTS:":[121],"The":[122,137,202],"inverse":[123,138,203],"association":[124,139],"between":[125,140],"circulating":[126,141],"borderline":[135],"significance.":[136],"levels":[142],"significant":[151],"CN":[153,211,247],"\u22651":[156],"diseases":[158],"[OR":[159,173,180,192],"(95%":[160,174,181],"CI):":[161,175,182],"0.75":[162],"(0.58-0.98)":[163],"(P=0.03)],":[164],"those":[165,216],"one":[167,218,224],"copy":[168],"APOE":[170,225],"alleles":[172],"0.43":[176],"(0.21-0.89)":[177],"(P=0.02)],":[178,185],"female":[179,214],"0.60":[183],"(0.38-0.94)":[184],"13":[188,231],"above":[189],"median":[191],"(95%CI):":[193],"0.69":[194],"(0.50-0.97)(P=0.03)]":[195],"after":[196],"adjusting":[197],"all":[199],"covariates.":[200],"CONCLUSION:":[201],"present":[206],"only":[207],"subgroups":[209],"including":[213],"individuals,":[215],"or":[219,223,228],"more":[220],"allele,":[227],"higher":[229],"scores.":[232],"If":[233],"confirmed,":[234],"this":[235],"finding":[236],"will":[237],"facilitate":[238],"precision":[239],"prevention":[240],"MCI,":[242],"turn,":[244],"older":[248],"adults.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-09-19T00:03:45.406941","created_date":"2025-10-10T00:00:00"}