{"id":"https://openalex.org/W4361968366","doi":"https://doi.org/10.1158/1078-0432.22451160.v1","title":"Supplementary Figure 6 from Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma","display_name":"Supplementary Figure 6 from Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361968366","doi":"https://doi.org/10.1158/1078-0432.22451160.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22451160.v1","doi":"https://doi.org/10.1158/1078-0432.22451160.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22451160.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.22451160.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034411606","display_name":"JulieAnn Rader","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JulieAnn Rader","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041038775","display_name":"Mike R. Russell","orcid":"https://orcid.org/0009-0009-5898-2020","observed_orcids":["https://orcid.org/0009-0009-5898-2020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mike R. Russell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008979088","display_name":"Lori S. Hart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lori S. Hart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084184628","display_name":"Michael S. Nakazawa","orcid":"https://orcid.org/0000-0002-6272-5467","observed_orcids":["https://orcid.org/0000-0002-6272-5467"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael S. Nakazawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048338781","display_name":"Lili T. Belcastro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lili T. Belcastro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100690100","display_name":"Daniel Mart\u0131\u0301nez","orcid":"https://orcid.org/0000-0001-7492-5311","observed_orcids":["https://orcid.org/0000-0001-7492-5311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Martinez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017202683","display_name":"Yimei Li","orcid":"https://orcid.org/0000-0001-9067-6992","observed_orcids":["https://orcid.org/0000-0001-9067-6992","https://orcid.org/0000-0002-7046-4316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yimei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029750461","display_name":"Erica L. Carpenter","orcid":"https://orcid.org/0000-0002-0735-3605","observed_orcids":["https://orcid.org/0000-0002-0735-3605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erica L. Carpenter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063279250","display_name":"Edward F. Attiyeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward F. Attiyeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064372210","display_name":"Sharon J. Diskin","orcid":"https://orcid.org/0000-0002-7200-8939","observed_orcids":["https://orcid.org/0000-0002-7200-8939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharon J. Diskin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000850685","display_name":"Sunkyu Kim","orcid":"https://orcid.org/0000-0002-0240-6210","observed_orcids":["https://orcid.org/0000-0002-0240-6210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunkyu Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110082","display_name":"Sudha Parasuraman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sudha Parasuraman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025118565","display_name":"Giordano Caponigro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giordano Caponigro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048354121","display_name":"Robert W. Schnepp","orcid":"https://orcid.org/0000-0003-3217-0381","observed_orcids":["https://orcid.org/0000-0003-3217-0381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert W. Schnepp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075837989","display_name":"Andrew Wood","orcid":"https://orcid.org/0000-0003-4850-6345","observed_orcids":["https://orcid.org/0000-0003-4850-6345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew C. Wood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063084227","display_name":"Bruce Pawel","orcid":"https://orcid.org/0000-0001-7678-5324","observed_orcids":["https://orcid.org/0000-0001-7678-5324"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce Pawel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005796905","display_name":"Kristina Ann Cole","orcid":"https://orcid.org/0000-0003-0064-2882","observed_orcids":["https://orcid.org/0000-0003-0064-2882"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristina A. Cole","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005797590","display_name":"John M. Maris","orcid":"https://orcid.org/0000-0002-8088-7929","observed_orcids":["https://orcid.org/0000-0002-8088-7929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Maris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribociclib","display_name":"ribociclib","score":0.9430000185966492},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8769999742507935},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.6759999990463257},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C199649820","wikidata":"https://www.wikidata.org/wiki/Q14911762","display_name":"Cyclin-dependent kinase 6","level":5,"score":0.7287765741348267},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4100706875324249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38046398758888245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34915295243263245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3438900113105774},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.29068228602409363},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.2690292000770569},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.237444669008255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21008101105690002},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17625123262405396}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22451160.v1","doi":"https://doi.org/10.1158/1078-0432.22451160.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22451160.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22451160","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_6_from_Dual_CDK4_CDK6_Inhibition_Induces_Cell-Cycle_Arrest_and_Senescence_in_Neuroblastoma/22451160","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22451160.v1","doi":"https://doi.org/10.1158/1078-0432.22451160.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22451160.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361958752","https://openalex.org/W2133382697","https://openalex.org/W2090961055","https://openalex.org/W2593287963","https://openalex.org/W4394271214","https://openalex.org/W2590284380","https://openalex.org/W2479872668","https://openalex.org/W2338950868","https://openalex.org/W6902422981","https://openalex.org/W2169310901"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"6":[2],"-":[3],"PDF":[4],"file":[5],"75K,":[6],"Statistical":[7],"analysis":[8],"of":[9,17,40],"in":[10],"vivo":[11],"growth":[12],"suppression.":[13],"(A)":[14],"Growth":[15],"rates":[16],"BE2C,":[18],"1643,":[19],"and":[20],"EBC1":[21],"xenografts":[22],"treated":[23],"with":[24],"200":[25],"mg/kg":[26],"LEE011":[27],"or":[28],"vehicle,":[29],"as":[30],"determined":[31],"by":[32],"linear":[33],"mixed":[34],"effects":[35],"analysis.":[36],"(B)":[37],"Summary":[38],"table":[39],"statistics":[41]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2023-04-05T00:00:00"}