{"id":"https://openalex.org/W4361968320","doi":"https://doi.org/10.1158/1078-0432.22451997.v1","title":"Supplementary Figure Legend and Tables 1 - 4 from CpG Island Methylator Phenotype\u2013Positive Tumors in the Absence of MLH1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis","display_name":"Supplementary Figure Legend and Tables 1 - 4 from CpG Island Methylator Phenotype\u2013Positive Tumors in the Absence of MLH1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361968320","doi":"https://doi.org/10.1158/1078-0432.22451997.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22451997.v1","doi":"https://doi.org/10.1158/1078-0432.22451997.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451997.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22451997.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039609611","display_name":"Tao Fu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Fu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070324294","display_name":"Emmanouil P. Pappou","orcid":"https://orcid.org/0000-0002-8735-1852","observed_orcids":["https://orcid.org/0000-0002-8735-1852"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emmanouil P. Pappou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040255726","display_name":"Angela A. Guzzetta","orcid":"https://orcid.org/0009-0009-1286-6059","observed_orcids":["https://orcid.org/0009-0009-1286-6059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela A. Guzzetta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066423730","display_name":"Jana Jeschke","orcid":"https://orcid.org/0000-0002-6047-2558","observed_orcids":["https://orcid.org/0000-0002-6047-2558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jana Jeschke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069847600","display_name":"Ruby Kwak","orcid":"https://orcid.org/0000-0002-2314-4088","observed_orcids":["https://orcid.org/0000-0002-2314-4088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruby Kwak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024249898","display_name":"Pujan Dave","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pujan Dave","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104276309","display_name":"Craig M. Hooker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig M. Hooker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103198733","display_name":"Richard A. Morgan","orcid":"https://orcid.org/0000-0003-0689-0916","observed_orcids":["https://orcid.org/0000-0003-0689-0916"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Morgan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058612163","display_name":"Stephen B. Baylin","orcid":"https://orcid.org/0000-0003-3697-3798","observed_orcids":["https://orcid.org/0000-0003-3697-3798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen B. Baylin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043757838","display_name":"Christine A. Iacobuzio\u2013Donahue","orcid":"https://orcid.org/0000-0002-4672-3023","observed_orcids":["https://orcid.org/0000-0002-4672-3023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine A. Iacobuzio-Donahue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051619233","display_name":"Christopher L. Wolfgang","orcid":"https://orcid.org/0009-0000-5817-6146","observed_orcids":["https://orcid.org/0009-0000-5817-6146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher L. Wolfgang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5114001695","display_name":"Nita Ahuja","orcid":"https://orcid.org/0000-0001-8293-1893","observed_orcids":["https://orcid.org/0000-0001-8293-1893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nita Ahuja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.09719999879598618,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cimp","display_name":"CpG island methylator phenotype","score":0.9120000004768372},{"id":"https://openalex.org/keywords/duodenal-adenocarcinoma","display_name":"duodenal adenocarcinoma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mlh1-promoter-methylation","display_name":"MLH1 promoter methylation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9549999833106995},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7440000176429749},{"id":"https://openalex.org/keywords/time-to-recurrence","display_name":"time to recurrence","score":0.7689999938011169},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C111425858","wikidata":"https://www.wikidata.org/wiki/Q14911708","display_name":"MLH1","level":5,"score":0.7333550453186035},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5445781350135803},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4899372458457947},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.4898354709148407},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.48124977946281433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44893723726272583},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.43799251317977905},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.41466134786605835},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.40416041016578674},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37446653842926025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33860576152801514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2983831465244293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29388338327407837},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16126692295074463},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.13359573483467102},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0900239646434784},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.07335877418518066},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.0561998188495636}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22451997.v1","doi":"https://doi.org/10.1158/1078-0432.22451997.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451997.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22451997","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_Legend_and_Tables_1_-_4_from_CpG_Island_Methylator_Phenotype_Positive_Tumors_in_the_Absence_of_i_MLH1_i_Methylation_Constitute_a_Distinct_Subset_of_Duodenal_Adenocarcinomas_and_Are_Associated_with_Poor_Prognosis/22451997","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22451997.v1","doi":"https://doi.org/10.1158/1078-0432.22451997.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451997.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361944474","https://openalex.org/W2095785927","https://openalex.org/W1978850955","https://openalex.org/W2552650822","https://openalex.org/W2042332797","https://openalex.org/W7202143847","https://openalex.org/W4392678560","https://openalex.org/W7170156024","https://openalex.org/W4405662821","https://openalex.org/W2136914254"],"abstract_inverted_index":{"PDF":[0],"file,":[1],"113K,":[2],"Supplementary":[3,6],"Figure":[4],"Legend;":[5],"Table":[7],"S1.":[8],"List":[9,18],"of":[10,19,35,52],"primers":[11],"used":[12],"for":[13,40,57],"methylation-specific":[14],"PCR;":[15],"S":[16],"2.":[17],"KRAS":[20],"mutations":[21],"in":[22],"patients":[23],"with":[24],"duodenal":[25],"Adenocarcinomas;":[26],"S3.":[27],"Five":[28],"year":[29,32],"and":[30,38,46,55],"10":[31],"cumulative":[33],"proportion":[34],"overall":[36,53],"survival":[37,54],"time-to-recurrence":[39,56],"different":[41],"molecular":[42],"groups;":[43],"S4.":[44],"Univariate":[45],"multivariate":[47],"Cox":[48],"proportional":[49],"hazard":[50],"analysis":[51],"CIMP,":[58],"MLH1":[59],"methylation":[60],"or":[61],"MSI":[62],"status.":[63]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2023-04-05T00:00:00"}
