{"id":"https://openalex.org/W4361968222","doi":"https://doi.org/10.1158/1078-0432.22451580","title":"Supplementary Figures 1 - 9 from Translation Initiation Factor eIF3b Expression in Human Cancer and Its Role in Tumor Growth and Lung Colonization","display_name":"Supplementary Figures 1 - 9 from Translation Initiation Factor eIF3b Expression in Human Cancer and Its Role in Tumor Growth and Lung Colonization","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361968222","doi":"https://doi.org/10.1158/1078-0432.22451580"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22451580","doi":"https://doi.org/10.1158/1078-0432.22451580","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451580","pdf_url":"https://aacr.figshare.com/ndownloader/files/39902658","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/ndownloader/files/39902658","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020781904","display_name":"Yuanbin Ru","orcid":"https://orcid.org/0000-0003-0509-1792","observed_orcids":["https://orcid.org/0000-0003-0509-1792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuanbin Ru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052620864","display_name":"Marta S\u00e4nchez\u2010Carbayo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Sanchez-Carbayo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617088","display_name":"Xuejiao Wang","orcid":"https://orcid.org/0009-0003-4163-4237","observed_orcids":["https://orcid.org/0009-0003-4163-4237"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuejiao Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082712375","display_name":"Jeffrey S. Kieft","orcid":"https://orcid.org/0000-0002-3718-1891","observed_orcids":["https://orcid.org/0000-0002-3718-1891"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey S. Kieft","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020183452","display_name":"Dan Theodorescu","orcid":"https://orcid.org/0000-0002-8708-8206","observed_orcids":["https://orcid.org/0000-0002-8708-8206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Theodorescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.26829999685287476,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eif3b","display_name":"eIF3b","score":0.9980000257492065},{"id":"https://openalex.org/keywords/eif3c","display_name":"eIF3c","score":0.8930000066757202},{"id":"https://openalex.org/keywords/translation-initiation-factors","display_name":"translation initiation factors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.7889999747276306},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":1.0},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8299999833106995},{"id":"https://openalex.org/keywords/lung-colonization","display_name":"lung colonization","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6579999923706055},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/integrin-alpha5","display_name":"integrin alpha5","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cell-spreading","display_name":"cell spreading","score":0.7670000195503235},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9700000286102295},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.9890000224113464},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6020382642745972},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4819038212299347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4750228524208069},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4490099251270294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12110179662704468}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22451580","doi":"https://doi.org/10.1158/1078-0432.22451580","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451580","pdf_url":"https://aacr.figshare.com/ndownloader/files/39902658","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22451580.v1","doi":"https://doi.org/10.1158/1078-0432.22451580.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451580.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22451580","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figures_1_-_9_from_Translation_Initiation_Factor_eIF3b_Expression_in_Human_Cancer_and_Its_Role_in_Tumor_Growth_and_Lung_Colonization/22451580","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22451580","doi":"https://doi.org/10.1158/1078-0432.22451580","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451580","pdf_url":"https://aacr.figshare.com/ndownloader/files/39902658","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361968222.pdf","grobid_xml":"https://content.openalex.org/works/W4361968222.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361944682","https://openalex.org/W2166365159","https://openalex.org/W1985050876","https://openalex.org/W4388748768","https://openalex.org/W2043453124","https://openalex.org/W3036194174","https://openalex.org/W2091589316","https://openalex.org/W2990075308","https://openalex.org/W4379966527","https://openalex.org/W2009011153"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"672K,":[3],"Figure":[4,16,21,36,43,53,65,77,93],"S1.":[5],"High":[6,23],"eIF3b":[7,18,24,41,47,57,69,81],"mRNA":[8,25],"expression":[9,26],"is":[10,27],"associated":[11,28],"with":[12,29],"human":[13,33],"bladder":[14],"cancer.":[15],"S2.":[17],"antibody":[19],"specificity":[20],"S3.":[22],"aggressive":[30],"phenotypes":[31],"in":[32,62,74,90],"prostate":[34,49],"cancer":[35,50,63],"S4.":[37],"Time":[38],"course":[39],"of":[40,46,56,68,80,96],"depletion.":[42],"S5.":[44],"Depletion":[45,55,67,79,95],"inhibits":[48,98],"cell":[51,60,83,99],"growth.":[52],"S6.":[54],"affects":[58],"the":[59],"cycle":[61],"cells.":[64,76,92],"S7.":[66],"does":[70],"not":[71],"induce":[72],"apoptosis":[73],"UMUC3":[75],"S8.":[78],"decreases":[82],"spreading":[84],"and":[85,103,108],"adhesion":[86],"through":[87],"integrin":[88],"alpha5":[89],"PC3":[91],"S9.":[94],"eIF3c":[97],"growth,":[100],"protein":[101],"synthesis":[102],"disrupts":[104],"actin":[105],"cytoskeleton":[106],"organization":[107],"focal":[109],"adhesion.":[110]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}