{"id":"https://openalex.org/W4361967802","doi":"https://doi.org/10.1158/1078-0432.22468071.v1","title":"Supplementary figure 1 from Transforming Growth Factor-\u03b2 Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors","display_name":"Supplementary figure 1 from Transforming Growth Factor-\u03b2 Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361967802","doi":"https://doi.org/10.1158/1078-0432.22468071.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22468071.v1","doi":"https://doi.org/10.1158/1078-0432.22468071.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22468071.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22468071.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054388259","display_name":"Ya\u2019an Kang","orcid":"https://orcid.org/0000-0002-2076-3692","observed_orcids":["https://orcid.org/0000-0002-2076-3692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya'an Kang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028941145","display_name":"David Roife","orcid":"https://orcid.org/0000-0001-9052-2248","observed_orcids":["https://orcid.org/0000-0001-9052-2248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Roife","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003528434","display_name":"Yeon\u2010Ju Lee","orcid":"https://orcid.org/0000-0003-4814-943X","observed_orcids":["https://orcid.org/0000-0003-4814-943X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yeonju Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013468381","display_name":"Hailong Lv","orcid":"https://orcid.org/0000-0002-2019-6376","observed_orcids":["https://orcid.org/0000-0002-2019-6376"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hailong Lv","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055817781","display_name":"Rei Suzuki","orcid":"https://orcid.org/0000-0002-4049-0484","observed_orcids":["https://orcid.org/0000-0002-4049-0484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rei Suzuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044222908","display_name":"Jianhua Ling","orcid":"https://orcid.org/0000-0002-1315-4389","observed_orcids":["https://orcid.org/0000-0002-1315-4389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianhua Ling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008087370","display_name":"Mayrim V. Rios Perez","orcid":"https://orcid.org/0000-0001-5584-1315","observed_orcids":["https://orcid.org/0000-0001-5584-1315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mayrim V. Rios Perez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043084593","display_name":"Xinqun Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinqun Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017157124","display_name":"BingBing Dai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"BingBing Dai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089136645","display_name":"Michael Pratt","orcid":"https://orcid.org/0000-0002-8939-7715","observed_orcids":["https://orcid.org/0000-0002-8939-7715"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Pratt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029404091","display_name":"Mark Joseph Truty","orcid":"https://orcid.org/0000-0003-3776-527X","observed_orcids":["https://orcid.org/0000-0003-3776-527X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark J. Truty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072825310","display_name":"Deyali Chatterjee","orcid":"https://orcid.org/0000-0002-3322-1163","observed_orcids":["https://orcid.org/0000-0002-3322-1163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deyali Chatterjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101758546","display_name":"Huamin Wang","orcid":"https://orcid.org/0000-0002-2038-5863","observed_orcids":["https://orcid.org/0000-0002-2038-5863"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huamin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075684432","display_name":"Ryan Michael Thomas","orcid":"https://orcid.org/0000-0001-9251-5543","observed_orcids":["https://orcid.org/0000-0001-9251-5543"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan M. Thomas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445094","display_name":"Yu Wang","orcid":"https://orcid.org/0000-0001-7811-5834","observed_orcids":["https://orcid.org/0000-0001-7811-5834","https://orcid.org/0000-0002-9658-659X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026500137","display_name":"Eugene Jon Koay","orcid":"https://orcid.org/0000-0001-7675-3461","observed_orcids":["https://orcid.org/0000-0001-7675-3461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugene J. Koay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068301962","display_name":"Paul J. Chiao","orcid":"https://orcid.org/0000-0001-7003-6605","observed_orcids":["https://orcid.org/0000-0001-7003-6605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul J. Chiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011254389","display_name":"Matthew H. G. Katz","orcid":"https://orcid.org/0000-0003-3870-6968","observed_orcids":["https://orcid.org/0000-0003-3870-6968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew H. Katz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037694904","display_name":"Jason B. Fleming","orcid":"https://orcid.org/0000-0002-8796-5627","observed_orcids":["https://orcid.org/0000-0002-8796-5627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason B. Fleming","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.43380001187324524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8659999966621399},{"id":"https://openalex.org/keywords/lumican","display_name":"lumican","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pancreatic-stellate-cells","display_name":"pancreatic stellate cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tgf-beta-secretion","display_name":"TGF-beta secretion","score":0.7310000061988831},{"id":"https://openalex.org/keywords/image-analysis-workflow","display_name":"image analysis workflow","score":0.515999972820282},{"id":"https://openalex.org/keywords/double-immunofluorescence","display_name":"double immunofluorescence","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C2779457992","wikidata":"https://www.wikidata.org/wiki/Q18028707","display_name":"Lumican","level":5,"score":0.8207467198371887},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.745417058467865},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6982446312904358},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.603691577911377},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.44302380084991455},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3854878544807434},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35993432998657227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35468950867652893},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3175694942474365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27905333042144775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23996210098266602},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.10346657037734985},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.10145893692970276},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.090050607919693},{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22468071.v1","doi":"https://doi.org/10.1158/1078-0432.22468071.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22468071.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22468071.v1","doi":"https://doi.org/10.1158/1078-0432.22468071.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22468071.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2344736690","https://openalex.org/W4361959623","https://openalex.org/W2006727249","https://openalex.org/W3016181576","https://openalex.org/W2618037606","https://openalex.org/W2047457616","https://openalex.org/W1975910155","https://openalex.org/W930392073","https://openalex.org/W3027841730","https://openalex.org/W1991557260"],"abstract_inverted_index":{"Vectra":[0],"Image":[1],"analysis":[2],"workflow,":[3],"Double":[4],"IF":[5],"staining":[6],"of":[7],"lumican":[8],"and":[9,12],"collagen":[10],"I,":[11],"TGF-\u03b2":[13],"secretion":[14],"in":[15],"HPSC.":[16]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2023-04-05T00:00:00"}