{"id":"https://openalex.org/W4361963203","doi":"https://doi.org/10.1158/1078-0432.22488011.v1","title":"Supplementary Figure from Preclinical and Pilot Study of Type I FLT3 Tyrosine Kinase Inhibitor, Crenolanib, with Sorafenib in Acute Myeloid Leukemia and FLT3-Internal Tandem Duplication","display_name":"Supplementary Figure from Preclinical and Pilot Study of Type I FLT3 Tyrosine Kinase Inhibitor, Crenolanib, with Sorafenib in Acute Myeloid Leukemia and FLT3-Internal Tandem Duplication","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361963203","doi":"https://doi.org/10.1158/1078-0432.22488011.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22488011.v1","doi":"https://doi.org/10.1158/1078-0432.22488011.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22488011.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22488011.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075936752","display_name":"Hiroto Inaba","orcid":"https://orcid.org/0000-0003-0605-7342","observed_orcids":["https://orcid.org/0000-0003-0605-7342"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroto Inaba","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0605-7342","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055786979","display_name":"Jolieke G. van Oosterwijk","orcid":"https://orcid.org/0000-0003-2282-6121","observed_orcids":["https://orcid.org/0000-0003-2282-6121"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jolieke G. van Oosterwijk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2282-6121","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039997334","display_name":"John Carl Panetta","orcid":"https://orcid.org/0000-0003-1308-7208","observed_orcids":["https://orcid.org/0000-0003-1308-7208"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John C. Panetta","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1308-7208","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016647580","display_name":"Lie Li","orcid":"https://orcid.org/0000-0003-1508-5484","observed_orcids":["https://orcid.org/0000-0003-1508-5484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lie Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019289825","display_name":"Daelynn R. Buelow","orcid":"https://orcid.org/0000-0002-4413-5711","observed_orcids":["https://orcid.org/0000-0002-4413-5711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daelynn R. Buelow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080781659","display_name":"James Stewart Blachly","orcid":"https://orcid.org/0000-0002-4275-5562","observed_orcids":["https://orcid.org/0000-0002-4275-5562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James S. Blachly","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4275-5562","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111418262","display_name":"Sheila A. Shurtleff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheila Shurtleff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018363328","display_name":"Ching\u2010Hon Pui","orcid":"https://orcid.org/0000-0003-0303-5658","observed_orcids":["https://orcid.org/0000-0003-0303-5658"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ching-Hon Pui","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0303-5658","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086250633","display_name":"Raul Correa Ribeiro","orcid":"https://orcid.org/0000-0002-9956-5647","observed_orcids":["https://orcid.org/0000-0002-9956-5647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raul C. Ribeiro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9956-5647","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065634145","display_name":"Jeffrey E. Rubnitz","orcid":"https://orcid.org/0000-0001-9885-3527","observed_orcids":["https://orcid.org/0000-0001-9885-3527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey E. Rubnitz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9885-3527","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064611054","display_name":"Stanley B Pounds","orcid":"https://orcid.org/0000-0002-9167-2114","observed_orcids":["https://orcid.org/0000-0002-9167-2114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stanley Pounds","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077260725","display_name":"Sharyn D. Baker","orcid":"https://orcid.org/0000-0003-3062-3252","observed_orcids":["https://orcid.org/0000-0003-3062-3252"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharyn D. Baker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3062-3252","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crenolanib","display_name":"crenolanib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.9819999933242798},{"id":"https://openalex.org/keywords/flt3-inhibitors","display_name":"FLT3 inhibitors","score":0.8790000081062317},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9729999899864197},{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.9440000057220459},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/preclinical-research","display_name":"preclinical research","score":0.5170000195503235},{"id":"https://openalex.org/keywords/pilot-study","display_name":"pilot study","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.8703435659408569},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7418156266212463},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.6397942900657654},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5381883382797241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5117645263671875},{"id":"https://openalex.org/C156446351","wikidata":"https://www.wikidata.org/wiki/Q7682435","display_name":"Tandem exon duplication","level":4,"score":0.4986748695373535},{"id":"https://openalex.org/C2910954276","wikidata":"https://www.wikidata.org/wiki/Q14912399","display_name":"Fms-Like Tyrosine Kinase 3","level":4,"score":0.4985203742980957},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48327523469924927},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34544074535369873},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2822137773036957},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.26349687576293945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2122473418712616},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10156604647636414},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09044831991195679},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.08369860053062439},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.08304205536842346},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07360392808914185},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05652621388435364}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22488011.v1","doi":"https://doi.org/10.1158/1078-0432.22488011.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22488011.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22488011.v1","doi":"https://doi.org/10.1158/1078-0432.22488011.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22488011.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2484833135","https://openalex.org/W2793373713","https://openalex.org/W2005831962","https://openalex.org/W2075312788","https://openalex.org/W4386496024","https://openalex.org/W4385899916","https://openalex.org/W3011987339","https://openalex.org/W2512058705","https://openalex.org/W1969154832","https://openalex.org/W2317475893"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"from":[2],"Preclinical":[3],"and":[4,21],"Pilot":[5],"Study":[6],"of":[7],"Type":[8],"I":[9],"FLT3":[10],"Tyrosine":[11],"Kinase":[12],"Inhibitor,":[13],"Crenolanib,":[14],"with":[15],"Sorafenib":[16],"in":[17],"Acute":[18],"Myeloid":[19],"Leukemia":[20],"FLT3-Internal":[22],"Tandem":[23],"Duplication":[24]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
