{"id":"https://openalex.org/W4361963128","doi":"https://doi.org/10.1158/1078-0432.22488120","title":"Supplementary Table from Preclinical Modeling of Leiomyosarcoma Identifies Susceptibility to Transcriptional CDK Inhibitors through Antagonism of E2F-Driven Oncogenic Gene Expression","display_name":"Supplementary Table from Preclinical Modeling of Leiomyosarcoma Identifies Susceptibility to Transcriptional CDK Inhibitors through Antagonism of E2F-Driven Oncogenic Gene Expression","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361963128","doi":"https://doi.org/10.1158/1078-0432.22488120"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22488120","doi":"https://doi.org/10.1158/1078-0432.22488120","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22488120","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22488120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011165297","display_name":"Matthew L. Hemming","orcid":"https://orcid.org/0000-0003-4674-7778","observed_orcids":["https://orcid.org/0000-0003-4674-7778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew L. Hemming","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4674-7778","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018461011","display_name":"Patrick D. Bhola","orcid":"https://orcid.org/0000-0002-2438-4526","observed_orcids":["https://orcid.org/0000-0002-2438-4526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Bhola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041841255","display_name":"Michael A. Loycano","orcid":"https://orcid.org/0000-0003-3597-7631","observed_orcids":["https://orcid.org/0000-0003-3597-7631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A. Loycano","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3597-7631","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049554127","display_name":"Justin A. Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin A. Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062259535","display_name":"Madeleine L. Taddei","orcid":"https://orcid.org/0000-0002-1302-5202","observed_orcids":["https://orcid.org/0000-0002-1302-5202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madeleine L. Taddei","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1302-5202","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065899382","display_name":"Leona A. Doyle","orcid":"https://orcid.org/0000-0003-1110-3753","observed_orcids":["https://orcid.org/0000-0003-1110-3753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leona A. Doyle","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1110-3753","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Elizaveta Lavrova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizaveta Lavrova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110596174","display_name":"Jessica L. Andersen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica L. Andersen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065388955","display_name":"Kelly S. Klega","orcid":"https://orcid.org/0000-0002-3424-2003","observed_orcids":["https://orcid.org/0000-0002-3424-2003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly S. Klega","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3424-2003","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081992551","display_name":"Morgan R. Benson","orcid":"https://orcid.org/0000-0002-7002-7976","observed_orcids":["https://orcid.org/0000-0002-7002-7976"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morgan R. Benson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009997118","display_name":"Brian D. Crompton","orcid":"https://orcid.org/0000-0001-9404-6621","observed_orcids":["https://orcid.org/0000-0001-9404-6621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian D. Crompton","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9404-6621","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056266239","display_name":"Chandrajit P. Raut","orcid":"https://orcid.org/0000-0001-7297-3221","observed_orcids":["https://orcid.org/0000-0001-7297-3221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chandrajit P. Raut","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7297-3221","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078289621","display_name":"Suzanne George","orcid":"https://orcid.org/0000-0002-1284-8493","observed_orcids":["https://orcid.org/0000-0002-1284-8493","https://orcid.org/0000-0002-8777-8530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suzanne George","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022857112","display_name":"Anthony G. Letai","orcid":"https://orcid.org/0000-0002-1993-9013","observed_orcids":["https://orcid.org/0000-0002-1993-9013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony Letai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1993-9013","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060580923","display_name":"George D. Demetri","orcid":"https://orcid.org/0000-0002-0045-4809","observed_orcids":["https://orcid.org/0000-0002-0045-4809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George D. Demetri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0045-4809","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045074422","display_name":"Ewa Sici\u0144ska","orcid":"https://orcid.org/0000-0001-7187-319X","observed_orcids":["https://orcid.org/0000-0001-7187-319X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ewa Sicinska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.41359999775886536,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leiomyosarcoma","display_name":"leiomyosarcoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/e2f-transcription-factors","display_name":"E2F transcription factors","score":0.7879999876022339},{"id":"https://openalex.org/keywords/oncogenic-gene-expression","display_name":"oncogenic gene expression","score":0.9769999980926514},{"id":"https://openalex.org/keywords/preclinical-cancer-models","display_name":"preclinical cancer models","score":0.6309999823570251},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.5199999809265137},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.7833517789840698},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.7825853824615479},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.506843626499176},{"id":"https://openalex.org/C83258922","wikidata":"https://www.wikidata.org/wiki/Q24771933","display_name":"E2F","level":4,"score":0.5052395462989807},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46827128529548645},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45827221870422363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4435761868953705},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.4325380325317383},{"id":"https://openalex.org/C2778298596","wikidata":"https://www.wikidata.org/wiki/Q17143494","display_name":"CDK inhibitor","level":5,"score":0.4231102168560028},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3287716209888458},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25354161858558655},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.23369815945625305},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13671299815177917},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08467662334442139},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22488120","doi":"https://doi.org/10.1158/1078-0432.22488120","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22488120","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22488120.v1","doi":"https://doi.org/10.1158/1078-0432.22488120.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22488120.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22488120","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Table_from_Preclinical_Modeling_of_Leiomyosarcoma_Identifies_Susceptibility_to_Transcriptional_CDK_Inhibitors_through_Antagonism_of_E2F-Driven_Oncogenic_Gene_Expression/22488120","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22488120","doi":"https://doi.org/10.1158/1078-0432.22488120","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22488120","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361967249","https://openalex.org/W4221114948","https://openalex.org/W4413851549","https://openalex.org/W4392685523","https://openalex.org/W3033194045","https://openalex.org/W2071759917","https://openalex.org/W4220749392","https://openalex.org/W4362537684","https://openalex.org/W4250062478","https://openalex.org/W4361954348"],"abstract_inverted_index":{"Supplementary":[0],"Table":[1],"from":[2],"Preclinical":[3],"Modeling":[4],"of":[5,15],"Leiomyosarcoma":[6],"Identifies":[7],"Susceptibility":[8],"to":[9],"Transcriptional":[10],"CDK":[11],"Inhibitors":[12],"through":[13],"Antagonism":[14],"E2F-Driven":[16],"Oncogenic":[17],"Gene":[18],"Expression":[19]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}