{"id":"https://openalex.org/W4361962555","doi":"https://doi.org/10.1158/1078-0432.22475772","title":"Supplemental Figure 3 from Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma","display_name":"Supplemental Figure 3 from Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361962555","doi":"https://doi.org/10.1158/1078-0432.22475772"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22475772","doi":"https://doi.org/10.1158/1078-0432.22475772","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22475772","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22475772","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025351354","display_name":"Benjamin M. Ellingson","orcid":"https://orcid.org/0000-0002-2764-6640","observed_orcids":["https://orcid.org/0000-0002-2764-6640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin M. Ellingson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2764-6640","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030410351","display_name":"Jingwen Yao","orcid":"https://orcid.org/0000-0002-8828-1841","observed_orcids":["https://orcid.org/0000-0002-8828-1841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingwen Yao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084168615","display_name":"Catalina Raymond","orcid":"https://orcid.org/0000-0003-2757-439X","observed_orcids":["https://orcid.org/0000-0003-2757-439X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catalina Raymond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004206249","display_name":"David A. Nathanson","orcid":"https://orcid.org/0000-0002-4919-9159","observed_orcids":["https://orcid.org/0000-0002-4919-9159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Nathanson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067837083","display_name":"Ararat Chakhoyan","orcid":"https://orcid.org/0000-0001-9447-495X","observed_orcids":["https://orcid.org/0000-0001-9447-495X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ararat Chakhoyan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082032382","display_name":"Jeremy C. Simpson","orcid":"https://orcid.org/0000-0002-7956-7805","observed_orcids":["https://orcid.org/0000-0002-7956-7805"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy Simpson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062059537","display_name":"James Stuart Garner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James S. Garner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103885960","display_name":"Alan G. Olivero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan G. Olivero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110236","display_name":"Lars U. Mueller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lars U. Mueller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031165814","display_name":"Jordi Ahnert Rodon","orcid":"https://orcid.org/0000-0001-6467-3632","observed_orcids":["https://orcid.org/0000-0001-6467-3632","https://orcid.org/0000-0003-2234-5248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordi Rodon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082835319","display_name":"Elizabeth Robins Gerstner","orcid":"https://orcid.org/0000-0003-2382-3838","observed_orcids":["https://orcid.org/0000-0003-2382-3838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Gerstner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063511816","display_name":"Timothy Francis Cloughesy","orcid":"https://orcid.org/0000-0002-8656-7483","observed_orcids":["https://orcid.org/0000-0002-8656-7483"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy F. Cloughesy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021656597","display_name":"Patrick Yung Wen","orcid":"https://orcid.org/0000-0002-0774-7700","observed_orcids":["https://orcid.org/0000-0002-0774-7700","https://orcid.org/0000-0003-3224-3042","https://orcid.org/0000-0002-2452-0540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Y. Wen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0689999982714653,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-high-grade-glioma","display_name":"recurrent high-grade glioma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9520000219345093},{"id":"https://openalex.org/keywords/fdg-uptake","display_name":"FDG uptake","score":0.8259999752044678},{"id":"https://openalex.org/keywords/apparent-diffusion-coefficient","display_name":"apparent diffusion coefficient","score":0.9160000085830688},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ktrans","display_name":"Ktrans","score":0.781000018119812},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.6909999847412109},{"id":"https://openalex.org/keywords/relative-cerebral-blood-volume","display_name":"relative cerebral blood volume","score":0.9100000262260437},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.7494154572486877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7065571546554565},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.6280728578567505},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.47166645526885986},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.46104878187179565},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3972531855106354},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.30083543062210083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.286124050617218},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22475772","doi":"https://doi.org/10.1158/1078-0432.22475772","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22475772","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22475772.v1","doi":"https://doi.org/10.1158/1078-0432.22475772.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22475772.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplemental_Figure_3_from_Multiparametric_MR-PET_Imaging_Predicts_Pharmacokinetics_and_Clinical_Response_to_GDC-0084_in_Patients_with_Recurrent_High-Grade_Glioma/22475772/1/files/39927279.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22475772","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplemental_Figure_3_from_Multiparametric_MR-PET_Imaging_Predicts_Pharmacokinetics_and_Clinical_Response_to_GDC-0084_in_Patients_with_Recurrent_High-Grade_Glioma/22475772","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22475772","doi":"https://doi.org/10.1158/1078-0432.22475772","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22475772","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361962555.pdf","grobid_xml":"https://content.openalex.org/works/W4361962555.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3015396224","https://openalex.org/W4361947355","https://openalex.org/W2986587395","https://openalex.org/W2999607433","https://openalex.org/W2985046962","https://openalex.org/W2899558373","https://openalex.org/W4251526733","https://openalex.org/W3036277413","https://openalex.org/W2092033269","https://openalex.org/W1966262477"],"abstract_inverted_index":{"Post-treatment":[0,13],"multi-parametric":[1],"MR-PET":[2],"imaging":[3],"measurements":[4,14,48],"and":[5,41,45,75,90],"responses":[6],"for":[7,79],"each":[8],"oral":[9],"dose":[10,80],"of":[11,15,49,82],"GDC-0084.":[12],"A)":[16],"contrast":[17,51],"enhancing":[18,52],"tumor":[19,53],"volume,":[20,54],"B)":[21],"median":[22,30,33,36,39,43,56,64,67,70,73,77],"18F-FDG":[23,57],"uptake":[24,58],"relative":[25,59],"to":[26,60],"white":[27,61],"matter,":[28,62],"C)":[29],"ADC,":[31,65],"D)":[32],"FA,":[34,68],"E)":[35],"Ktrans,":[37,71],"F)":[38],"vp\u00ac,":[40,74],"G)":[42],"rCBV":[44,78],"change":[46],"in":[47],"H)":[50],"I)":[55],"J)":[63],"K)":[66],"L)":[69],"M)":[72],"N)":[76],"levels":[81],"2,":[83],"4,":[84],"8,":[85],"15,":[86],"20,":[87],"30,":[88],"45,":[89],"65mg.":[91]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}