{"id":"https://openalex.org/W4361961413","doi":"https://doi.org/10.1158/1078-0432.c.6518745","title":"Data from Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth","display_name":"Data from Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361961413","doi":"https://doi.org/10.1158/1078-0432.c.6518745"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6518745","doi":"https://doi.org/10.1158/1078-0432.c.6518745","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6518745","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6518745","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026243943","display_name":"Zhuohan Zhang","orcid":"https://orcid.org/0009-0000-0138-6070","observed_orcids":["https://orcid.org/0009-0000-0138-6070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhuohan Zhang","raw_affiliation_strings":["Department of Immunology, College of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, College of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101873697","display_name":"Xiaoying Yang","orcid":"https://orcid.org/0000-0001-8382-9719","observed_orcids":["https://orcid.org/0000-0001-8382-9719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoying Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yuan Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Zhang","raw_affiliation_strings":["Department of Immunology, College of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, College of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110400","display_name":"Bin Zeng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Zeng","raw_affiliation_strings":["Department of Immunology, College of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, College of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101574358","display_name":"Shujing Wang","orcid":"https://orcid.org/0000-0003-0050-3794","observed_orcids":["https://orcid.org/0000-0003-0050-3794"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shujing Wang","raw_affiliation_strings":["Institute of Polymer Chemistry and Key Laboratory for Functional Polymer Materials, College of Chemistry, Nankai University, Tianjin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Polymer Chemistry and Key Laboratory for Functional Polymer Materials, College of Chemistry, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tianhui Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tianhui Zhu","raw_affiliation_strings":["Department of Immunology, College of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, College of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089035026","display_name":"Richard B. S. Roden","orcid":"https://orcid.org/0000-0002-2506-0195","observed_orcids":["https://orcid.org/0000-0002-2506-0195"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard B.S. Roden","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739153","display_name":"Yongsheng Chen","orcid":"https://orcid.org/0000-0001-5835-8249","observed_orcids":["https://orcid.org/0000-0001-5835-8249"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Yongsheng Chen","raw_affiliation_strings":["Department of Immunology, College of Medicine,","Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","Institute of Polymer Chemistry and Key Laboratory for Functional Polymer Materials, College of Chemistry, Nankai University, Tianjin, People's Republic of China","Key Laboratory of Bioactive Materials, Ministry of Education, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, College of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Institute of Polymer Chemistry and Key Laboratory for Functional Polymer Materials, College of Chemistry, Nankai University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Key Laboratory of Bioactive Materials, Ministry of Education, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003295967","display_name":"Rongcun Yang","orcid":"https://orcid.org/0000-0002-5826-4493","observed_orcids":["https://orcid.org/0000-0002-5826-4493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rongcun Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100739153"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I205237279","https://openalex.org/I2799853436"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12627","display_name":"Graphene and Nanomaterials Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.8550000190734863},{"id":"https://openalex.org/keywords/single-walled-carbon-nanotubes","display_name":"single-walled carbon nanotubes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6579999923706055},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.7699999809265137},{"id":"https://openalex.org/keywords/lewis-lung-carcinoma","display_name":"Lewis lung carcinoma","score":0.6420000195503235},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/sirna-therapeutics","display_name":"siRNA therapeutics","score":0.7649999856948853},{"id":"https://openalex.org/keywords/transporters","display_name":"transporters","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5601229667663574},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.536468505859375},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.5212976932525635},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.29600122570991516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20693036913871765},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.165084570646286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15444660186767578}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6518745","doi":"https://doi.org/10.1158/1078-0432.c.6518745","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6518745","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6518745","doi":"https://doi.org/10.1158/1078-0432.c.6518745","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6518745","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G150120987","display_name":null,"funder_award_id":"043803711","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2480156884","display_name":null,"funder_award_id":"OC010017","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320323021","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1494841933","https://openalex.org/W1969417925","https://openalex.org/W1982822058","https://openalex.org/W1990438204","https://openalex.org/W1993243592","https://openalex.org/W1999284097","https://openalex.org/W2000971601","https://openalex.org/W2013871293","https://openalex.org/W2015037479","https://openalex.org/W2026856852","https://openalex.org/W2046741906","https://openalex.org/W2051511277","https://openalex.org/W2070564266","https://openalex.org/W2095344091","https://openalex.org/W2104908670","https://openalex.org/W2109948235","https://openalex.org/W2116648662","https://openalex.org/W2139124024","https://openalex.org/W2147319330","https://openalex.org/W2171249989"],"related_works":["https://openalex.org/W2119702552","https://openalex.org/W4391893319","https://openalex.org/W2400184085","https://openalex.org/W2893974956","https://openalex.org/W1979283436","https://openalex.org/W2101927055","https://openalex.org/W2165243439","https://openalex.org/W2316197685","https://openalex.org/W4404940499","https://openalex.org/W2406643997"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"To":[2],"determine":[3],"whether":[4],"-CONH-(CH2)6-NH3+Cl\u2212":[5,34,88,163,187],"functionalized":[6,86,108,164,188],"single-walled":[7],"carbon":[8],"nanotubes":[9],"(SWNT)":[10],"carrying":[11],"complexed":[12,167],"small":[13],"interfering":[14],"RNA":[15],"(siRNA)":[16],"can":[17],"enter":[18],"into":[19,130,157,169],"tumor":[20,75,115,136,170],"cells,":[21,171],"wherein":[22,172],"they":[23,173],"release":[24,174],"the":[25,29,39,60,70,91,103,145,175,178,183],"siRNA":[26,46,53,168,176,200],"to":[27,37,47,58,101,181],"silence":[28,59,182],"targeted":[30,184],"gene.":[31,185],"Experimental":[32],"Design:":[33],"was":[35,64],"used":[36],"mediate":[38],"conjugation":[40],"of":[41,51,62,74,93,126,147,195],"telomerase":[42],"reverse":[43],"transcriptase":[44],"(TERT)":[45],"SWNTs.":[48],"The":[49,85,186],"ability":[50],"TERT":[52,63,99,140],"delivered":[54],"via":[55],"SWNT":[56],"complexes":[57,129,142],"expression":[61,100],"assessed":[65],"by":[66],"their":[67],"effects":[68],"on":[69],"proliferation":[71],"and":[72,80,121,154],"growth":[73,123,146],"cells":[76,150],"both":[77,151],"in":[78,81,152,159],"vitro":[79,153],"mouse":[82],"models.":[83],"Results:":[84],"SWNTs":[87,109,165,189],"could":[89],"facilitate":[90],"coupling":[92],"siRNAs":[94],"that":[95],"specifically":[96],"target":[97],"murine":[98,114],"form":[102],"mTERT":[104,119,127],"siRNA:SWNT+":[105,128,141],"complex.":[106],"These":[107],"rapidly":[110],"entered":[111],"three":[112],"cultured":[113],"cell":[116],"lines,":[117],"suppressed":[118,144],"expression,":[120],"produced":[122],"arrest.":[124],"Injection":[125],"s.c.":[131],"Lewis":[132],"lung":[133],"tumors":[134,158],"reduced":[135],"growth.":[137],"Furthermore,":[138],"human":[139,148],"also":[143],"HeLa":[149],"when":[155],"injected":[156],"nude":[160],"mice.":[161],"Conclusions:":[162],"carry":[166],"from":[177],"nanotube":[179],"sidewalls":[180],"may":[190],"represent":[191],"a":[192],"new":[193],"class":[194],"molecular":[196],"transporters":[197],"applicable":[198],"for":[199],"therapeutics.":[201]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-04-05T00:00:00"}
