{"id":"https://openalex.org/W4361960225","doi":"https://doi.org/10.1158/1078-0432.c.6527523","title":"Data from Engineering the TGF\u03b2 Receptor to Enhance the Therapeutic Potential of Natural Killer Cells as an Immunotherapy for Neuroblastoma","display_name":"Data from Engineering the TGF\u03b2 Receptor to Enhance the Therapeutic Potential of Natural Killer Cells as an Immunotherapy for Neuroblastoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361960225","doi":"https://doi.org/10.1158/1078-0432.c.6527523"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6527523","doi":"https://doi.org/10.1158/1078-0432.c.6527523","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6527523","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6527523","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003003191","display_name":"Rachel A. Burga","orcid":"https://orcid.org/0000-0002-0204-8986","observed_orcids":["https://orcid.org/0000-0002-0204-8986"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel A. Burga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082887496","display_name":"Eric S. Yvon","orcid":"https://orcid.org/0000-0003-3822-6710","observed_orcids":["https://orcid.org/0000-0003-3822-6710"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Yvon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083117389","display_name":"Elizabeth A. Chorvinsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Chorvinsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041746704","display_name":"Rohan Fernandes","orcid":"https://orcid.org/0000-0001-9439-4626","observed_orcids":["https://orcid.org/0000-0001-9439-4626"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rohan Fernandes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9439-4626","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033997937","display_name":"Carolina Colli Cruz","orcid":"https://orcid.org/0000-0001-7065-3769","observed_orcids":["https://orcid.org/0000-0001-7065-3769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Russell Y. Cruz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006134549","display_name":"Catherine M. Bollard","orcid":"https://orcid.org/0000-0001-5140-9090","observed_orcids":["https://orcid.org/0000-0001-5140-9090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine M. Bollard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.8579999804496765},{"id":"https://openalex.org/keywords/tgf-beta-receptor","display_name":"TGF-beta receptor","score":0.7950000166893005},{"id":"https://openalex.org/keywords/dominant-negative-receptor","display_name":"dominant negative receptor","score":0.796999990940094},{"id":"https://openalex.org/keywords/off-the-shelf-cell-therapy","display_name":"off-the-shelf cell therapy","score":0.859000027179718},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7350000143051147},{"id":"https://openalex.org/keywords/immunosuppressive-cytokines","display_name":"immunosuppressive cytokines","score":0.9229999780654907},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.5009999871253967},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6126066446304321},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5939598083496094},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5539813041687012},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5295549035072327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49008285999298096},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.44147124886512756},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.43912526965141296},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4151574671268463},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41433846950531006},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.4142317771911621},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3751339912414551},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26118993759155273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23169368505477905},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18602371215820312},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.15847784280776978},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6527523","doi":"https://doi.org/10.1158/1078-0432.c.6527523","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6527523","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6527523","doi":"https://doi.org/10.1158/1078-0432.c.6527523","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6527523","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2801220820","https://openalex.org/W4313383613","https://openalex.org/W2611062837","https://openalex.org/W7110473585","https://openalex.org/W2572765595","https://openalex.org/W4280625909","https://openalex.org/W4393095522","https://openalex.org/W4414494175","https://openalex.org/W7125426912","https://openalex.org/W4288447006"],"abstract_inverted_index":{"AbstractPurpose:":[0],"The":[1],"ability":[2],"of":[3,38,65,79,89,104,202],"natural":[4],"killer":[5],"(NK)":[6],"cells":[7,42,49,106,135,171],"to":[8,136,148,165],"lyse":[9],"allogeneic":[10],"targets,":[11],"without":[12],"the":[13,74,101,113,200],"need":[14],"for":[15,25,35,43,76,97],"explicit":[16],"matching":[17],"or":[18],"priming,":[19],"makes":[20],"them":[21],"an":[22,94],"attractive":[23],"platform":[24],"cell-based":[26],"immunotherapy.":[27],"Umbilical":[28],"cord":[29],"blood":[30],"is":[31,73,85,107],"a":[32,63,77,86,143,179],"practical":[33],"source":[34],"generating":[36],"banks":[37],"such":[39,116],"third-party":[40],"NK":[41,48,105,121,134,170,205],"\u201coff-the-shelf\u201d":[44,203],"cell":[45,122],"therapy":[46],"applications.":[47],"are":[50,162],"highly":[51],"cytolytic,":[52],"and":[53,93,124,184,216],"their":[54,193],"potent":[55],"antitumor":[56,102],"effects":[57],"can":[58],"be":[59],"rapidly":[60],"triggered":[61],"by":[62,109],"lack":[64],"HLA":[66],"expression":[67],"on":[68],"interacting":[69],"target":[70],"cells,":[71,206],"as":[72,117,190],"case":[75],"majority":[78],"solid":[80],"tumors,":[81],"including":[82],"neuroblastoma.":[83],"Neuroblastoma":[84],"leading":[87],"cause":[88],"pediatric":[90],"cancer\u2013related":[91],"deaths":[92],"ideal":[95],"candidate":[96],"NK-cell":[98],"therapy.":[99],"However,":[100],"efficacy":[103],"limited":[108],"immunosuppressive":[110],"cytokines":[111],"in":[112,178,182,188,212],"tumor":[114],"microenvironment,":[115],"TGF\u03b2,":[118],"which":[119,141],"impair":[120],"function":[123],"survival.":[125],"Experimental":[126],"Design:":[127],"To":[128],"overcome":[129,208],"this,":[130],"we":[131],"genetically":[132],"modified":[133],"express":[137],"variant":[138],"TGF\u03b2":[139,145,160],"receptors,":[140,158],"couple":[142],"mutant":[144],"dominant-negative":[146],"receptor":[147],"NK-specific":[149],"activating":[150,166],"domains.":[151],"We":[152],"hypothesized":[153],"that":[154,207],"with":[155,192,214],"these":[156],"engineered":[157],"inhibitory":[159],"signals":[161],"effectively":[163],"converted":[164],"signals.":[167],"Results:":[168],"Modified":[169],"exhibited":[172],"higher":[173],"cytotoxic":[174],"activity":[175],"against":[176],"neuroblastoma":[177,215],"TGF\u03b2-rich":[180],"environment":[181],"vitro":[183],"superior":[185],"progression-free":[186],"survival":[187],"vivo,":[189],"compared":[191],"unmodified":[194],"controls.":[195],"Conclusions:":[196],"Our":[197],"results":[198],"support":[199],"development":[201],"gene-modified":[204],"TGF\u03b2-mediated":[209],"immune":[210],"evasion,":[211],"patients":[213],"other":[217],"TGF\u03b2-secreting":[218],"malignancies.":[219]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}
