{"id":"https://openalex.org/W4361959508","doi":"https://doi.org/10.1158/1078-0432.c.6529760","title":"Data from Acute Statin Treatment Improves Antibody Accumulation in EGFR- and PSMA-Expressing Tumors","display_name":"Data from Acute Statin Treatment Improves Antibody Accumulation in EGFR- and PSMA-Expressing Tumors","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361959508","doi":"https://doi.org/10.1158/1078-0432.c.6529760"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6529760","doi":"https://doi.org/10.1158/1078-0432.c.6529760","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6529760","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6529760","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085046089","display_name":"Patr\u00edcia M. Pereira","orcid":"https://orcid.org/0000-0002-4828-7632","observed_orcids":["https://orcid.org/0000-0002-4828-7632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patr\u00edcia M.R. Pereira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110505403","display_name":"Komal Mandleywala","orcid":"https://orcid.org/0009-0002-3455-7213","observed_orcids":["https://orcid.org/0009-0002-3455-7213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Komal Mandleywala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043154738","display_name":"Ashwin Ragupathi","orcid":"https://orcid.org/0000-0002-0931-7667","observed_orcids":["https://orcid.org/0000-0002-0931-7667","https://orcid.org/0009-0009-4075-1371"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashwin Ragupathi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068928963","display_name":"Jason Stuart Lewis","orcid":"https://orcid.org/0000-0001-7065-4534","observed_orcids":["https://orcid.org/0000-0001-7065-4534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason S. Lewis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7065-4534","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9959999918937683},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7379999756813049},{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.8080000281333923},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.7879999876022339},{"id":"https://openalex.org/keywords/antibody-accumulation","display_name":"antibody accumulation","score":0.5040000081062317},{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":0.6840000152587891},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":1.0},{"id":"https://openalex.org/keywords/rosuvastatin","display_name":"rosuvastatin","score":1.0},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cavin-1","display_name":"cavin-1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/endophilin","display_name":"endophilin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/clathrin","display_name":"clathrin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dynamin","display_name":"dynamin","score":1.0},{"id":"https://openalex.org/keywords/panitumumab","display_name":"panitumumab","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":1.0},{"id":"https://openalex.org/keywords/89zr-labeled-antibody","display_name":"89Zr-labeled antibody","score":0.9010000228881836},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.583355188369751},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5680407285690308},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.5652891397476196},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.5207676291465759},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.48272082209587097},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.40337246656417847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38167861104011536},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3425990343093872},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2995578646659851},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23409566283226013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21062308549880981},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.13718271255493164},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.12796270847320557}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6529760","doi":"https://doi.org/10.1158/1078-0432.c.6529760","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6529760","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6529760","doi":"https://doi.org/10.1158/1078-0432.c.6529760","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6529760","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3091596778","https://openalex.org/W3182468471","https://openalex.org/W1496798385","https://openalex.org/W2087688280","https://openalex.org/W2045712888","https://openalex.org/W4382537626","https://openalex.org/W2888576749","https://openalex.org/W2051474057","https://openalex.org/W2038009322","https://openalex.org/W3109932450"],"abstract_inverted_index":{"AbstractPurpose:":[0],"Statins":[1,162],"are":[2,31,43],"cholesterol-depleting":[3],"drugs":[4],"used":[5,116],"to":[6,73,117,132,209,230],"treat":[7],"patients":[8],"with":[9,225],"hypercholesterolemia.":[10],"Preclinically,":[11],"statins":[12,184,208],"disrupt":[13],"trafficking":[14],"of":[15,77,86,121,183,188,195,200,207,215],"receptors":[16,216],"present":[17],"at":[18,51,66,106,217],"the":[19,52,67,74,78,84,107,119,156,181,205,212,218],"cell":[20,53,68,109,219],"membrane.":[21],"Membrane":[22],"receptors,":[23],"defined":[24],"as":[25,185],"tumor":[26,108],"biomarkers":[27],"and":[28,41,89,99,139,160,169,174],"therapeutic":[29,231],"targets,":[30],"often":[32,47,223],"internalized":[33],"by":[34],"an":[35],"endocytic":[36,136,189],"pathway.":[37],"Indeed,":[38],"receptor":[39,49,64,97,104],"endocytosis":[40],"recycling":[42],"dynamic":[44],"mechanisms":[45],"that":[46],"affect":[48],"density":[50,65,105],"surface.":[54,110],"In":[55],"therapies":[56],"using":[57,147],"monoclonal":[58],"antibodies":[59,123],"(mAb),":[60],"a":[61,221],"downregulation":[62],"in":[63,91,124,135,172,204,228],"surface":[69,141],"decreases":[70],"antibody":[71],"binding":[72,120],"extracellular":[75],"domain":[76],"membrane":[79,101],"receptor.":[80],"Here,":[81],"we":[82],"determined":[83],"potential":[85,182,206],"lovastatin,":[87,148],"simvastatin,":[88,149],"rosuvastatin":[90,151],"preclinically":[92],"modulating":[93],"epidermal":[94],"growth":[95],"factor":[96],"(EGFR)":[98],"prostate-specific":[100],"antigen":[102],"(PSMA)":[103],"Experimental":[111],"Design:":[112],"Small-animal":[113],"PET":[114],"was":[115],"study":[118],"89Zr-labeled":[122],"ectopic":[125],"xenografts.":[126,176],"Ex":[127],"vivo":[128],"analyses":[129],"were":[130],"performed":[131],"determine":[133],"changes":[134],"proteins,":[137],"EGFR,":[138],"PSMA":[140],"levels.":[142],"Results:":[143],"Acute":[144],"statin":[145],"treatment":[146],"or":[150],"enhanced":[152],"tumors'":[153,193],"avidity":[154],"for":[155,191],"mAbs":[157],"panitumumab,":[158],"cetuximab,":[159],"huJ591.":[161],"temporarily":[163,210],"modulated":[164],"caveolin-1,":[165],"cavin-1,":[166],"endophilin,":[167],"clathrin,":[168],"dynamin":[170],"proteins":[171,190],"EGFR-":[173],"PSMA-overexpressing":[175],"Conclusions:":[177],"These":[178],"data":[179],"show":[180],"pharmacologic":[186],"modulators":[187],"improved":[192],"accumulation":[194],"mAbs.":[196],"The":[197],"translational":[198],"significance":[199],"these":[201],"findings":[202],"lies":[203],"modulate":[211],"heterogeneous":[213],"presence":[214],"membrane,":[220],"characteristic":[222],"associated":[224],"poor":[226],"response":[227],"tumors":[229],"antibodies.":[232]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-05T00:00:00"}