{"id":"https://openalex.org/W4361959331","doi":"https://doi.org/10.1158/1078-0432.c.6528570","title":"Data from A Phase I/II Trial of Cetuximab in Combination with Interleukin-12 Administered to Patients with Unresectable Primary or Recurrent Head and Neck Squamous Cell Carcinoma","display_name":"Data from A Phase I/II Trial of Cetuximab in Combination with Interleukin-12 Administered to Patients with Unresectable Primary or Recurrent Head and Neck Squamous Cell Carcinoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361959331","doi":"https://doi.org/10.1158/1078-0432.c.6528570"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6528570","doi":"https://doi.org/10.1158/1078-0432.c.6528570","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6528570","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6528570","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028975540","display_name":"Elizabeth L. McMichael","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth L. McMichael","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073968481","display_name":"Brooke N. Benner","orcid":"https://orcid.org/0000-0001-7471-6886","observed_orcids":["https://orcid.org/0000-0001-7471-6886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brooke Benner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033505983","display_name":"Lakhvir S. Atwal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lakhvir S. Atwal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083608306","display_name":"Nicholas B. Courtney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas B. Courtney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015153331","display_name":"Xiaokui Molly Mo","orcid":"https://orcid.org/0000-0002-9797-2687","observed_orcids":["https://orcid.org/0000-0002-9797-2687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaokui Mo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082352583","display_name":"Melanie E. Davis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melanie E. Davis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102890276","display_name":"Amanda R. Campbell","orcid":"https://orcid.org/0000-0002-0359-3900","observed_orcids":["https://orcid.org/0000-0002-0359-3900"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda R. Campbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080361449","display_name":"Megan Christina Duggan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megan C. Duggan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053484014","display_name":"Kallan Williams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kallan Williams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056489446","display_name":"Kyle A. Martin","orcid":"https://orcid.org/0000-0001-7402-9306","observed_orcids":["https://orcid.org/0000-0001-7402-9306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyle Martin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7402-9306","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054983553","display_name":"Kala M. Levine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kala Levine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024285638","display_name":"Gonzalo N. Olaverria Salavaggione","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gonzalo N. Olaverria Salavaggione","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079526097","display_name":"Tiffany C. Noel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tiffany Noel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005521067","display_name":"Akaansha Ganju","orcid":"https://orcid.org/0000-0003-0395-9287","observed_orcids":["https://orcid.org/0000-0003-0395-9287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akaansha Ganju","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054522457","display_name":"Sarvani Uppati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarvani Uppati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006315280","display_name":"Bonnie K. Paul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bonnie Paul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063621818","display_name":"Thomas E. Olencki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Olencki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112408130","display_name":"Theodoros Nicholas Teknos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theodoros N. Teknos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Panos Savvides","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Panos Savvides","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050245185","display_name":"Susheela Tridandapani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susheela Tridandapani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000921376","display_name":"John C. Byrd","orcid":"https://orcid.org/0000-0001-9830-0711","observed_orcids":["https://orcid.org/0000-0001-9830-0711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John C. Byrd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049192022","display_name":"Michael A. Caligiuri","orcid":"https://orcid.org/0000-0002-4095-3020","observed_orcids":["https://orcid.org/0000-0002-4095-3020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A. Caligiuri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043871151","display_name":"Stephen V. Liu","orcid":"https://orcid.org/0000-0002-4852-3914","observed_orcids":["https://orcid.org/0000-0002-4852-3914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen V. Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060897770","display_name":"William Edgar Carson","orcid":"https://orcid.org/0000-0001-7024-7533","observed_orcids":["https://orcid.org/0000-0001-7024-7533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William E. Carson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":1.0},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":1.0},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7279999852180481},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/fc-gamma-receptor-polymorphisms","display_name":"Fc gamma receptor polymorphisms","score":0.7070000171661377},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5350000262260437},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.734000027179718},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.7639999985694885},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7409999966621399},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.46399998664855957},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.9140334129333496},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.7580903768539429},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.7404629588127136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.632836103439331},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5125136375427246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45600637793540955},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.4243859052658081},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4030722975730896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3805190622806549},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3617236018180847},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.35106292366981506},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33694013953208923},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30406492948532104},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2879467010498047},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.18675851821899414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14164671301841736},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.08852210640907288},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6528570","doi":"https://doi.org/10.1158/1078-0432.c.6528570","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6528570","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6528570","doi":"https://doi.org/10.1158/1078-0432.c.6528570","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6528570","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2947405510","https://openalex.org/W2499805877","https://openalex.org/W2010034291","https://openalex.org/W2285565248","https://openalex.org/W4250974847","https://openalex.org/W2045699669","https://openalex.org/W2494070343","https://openalex.org/W2947605058","https://openalex.org/W2919425020","https://openalex.org/W2885888055"],"abstract_inverted_index":{"AbstractPurpose:":[0],"mAbs":[1],"including":[2],"cetuximab":[3,62,77,149,238],"can":[4],"induce":[5],"antibody-dependent":[6],"cellular":[7],"cytotoxicity":[8],"(ADCC)":[9],"and":[10,40,47,52,71,96,115,124,133,150,201,213,241],"cytokine":[11],"production":[12,48,197],"mediated":[13],"via":[14,36],"innate":[15],"immune":[16],"cells":[17,35],"with":[18,63,84,103,174,183,194,210,237],"the":[19,37,41,59,66,99,204],"ability":[20],"to":[21,113,224],"recognize":[22],"mAb-coated":[23],"tumors.":[24],"Preclinical":[25],"modeling":[26],"has":[27],"shown":[28],"that":[29,176],"costimulation":[30],"of":[31,49,61,68,76,98,120,128,136,148,162,170,198,206,217,229],"natural":[32],"killer":[33],"(NK)":[34],"Fc":[38],"receptor":[39,43],"IL12":[42,64,91,151,230],"promotes":[44],"NK-cell\u2013mediated":[45],"ADCC":[46,189],"cytokines.":[50],"Patients":[51],"Methods:":[53],"This":[54],"phase":[55],"I/II":[56],"trial":[57],"evaluated":[58],"combination":[60,147,236],"for":[65],"treatment":[67,114],"EGFR-expressing":[69],"head":[70,240],"neck":[72,242],"cancer.":[73],"Treatment":[74],"consisted":[75],"500":[78],"mg/m2":[79],"i.v.":[80],"every":[81],"2":[82,95],"weeks":[83],"either":[85],"0.2":[86],"mcg/kg":[87,90],"or":[88],"0.3":[89],"s.c.":[92],"on":[93],"days":[94,186],"5":[97],"2-week":[100],"cycle,":[101],"beginning":[102,205],"cycle":[104,207],"2.":[105],"Correlative":[106],"studies":[107],"from":[108],"blood":[109],"draws":[110],"obtained":[111],"prior":[112,223],"during":[116],"therapy":[117,191],"included":[118],"measurement":[119],"ADCC,":[121],"serum":[122],"cytokine,":[123],"chemokine":[125],"analysis,":[126],"determination":[127],"NK":[129],"cell":[130,139,244],"Fc\u03b3RIIIa":[131],"polymorphisms,":[132],"an":[134,232],"analysis":[135],"myeloid-derived":[137],"suppressor":[138],"(MDSC)":[140],"frequency":[141],"in":[142,235,239],"peripheral":[143],"blood.":[144],"Results:":[145],"The":[146],"was":[152],"well":[153],"tolerated.":[154],"No":[155],"clinical":[156,180],"responses":[157],"were":[158],"observed,":[159],"however,":[160],"48%":[161],"patients":[163,175,182],"exhibited":[164,187],"prolonged":[165],"progression-free":[166],"survival":[167],"(PFS;":[168],"average":[169],"6.5":[171],"months).":[172],"Compared":[173],"did":[177],"not":[178],"exhibit":[179],"benefit,":[181],"PFS":[184],">100":[185],"increased":[188],"as":[190,231],"continued":[192],"compared":[193,209],"baseline,":[195],"greater":[196],"IFN\u03b3,":[199],"IP-10,":[200],"TNF\u03b1":[202],"at":[203],"8":[208],"baseline":[211],"values":[212],"had":[214],"a":[215],"predominance":[216],"monocytic":[218],"MDSCs":[219,222],"versus":[220],"granulocytic":[221],"therapy.":[225],"Conclusions:":[226],"Further":[227],"investigation":[228],"immunomodulatory":[233],"agent":[234],"squamous":[243],"carcinoma":[245],"is":[246],"warranted.":[247]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2023-04-05T00:00:00"}