{"id":"https://openalex.org/W4361959110","doi":"https://doi.org/10.1158/1535-7163.c.6531617","title":"Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells","display_name":"Data from HYD1-induced increase in reactive oxygen species leads to autophagy and necrotic cell death in multiple myeloma cells","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361959110","doi":"https://doi.org/10.1158/1535-7163.c.6531617"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6531617","doi":"https://doi.org/10.1158/1535-7163.c.6531617","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6531617","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.c.6531617","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rajesh R. Nair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajesh R. Nair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013287959","display_name":"Michael F. Emmons","orcid":"https://orcid.org/0000-0002-0008-8335","observed_orcids":["https://orcid.org/0000-0002-0008-8335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael F. Emmons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080838230","display_name":"Anne E. Cress","orcid":"https://orcid.org/0000-0001-6194-0061","observed_orcids":["https://orcid.org/0000-0001-6194-0061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne E. Cress","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010781287","display_name":"Raul F. Argilagos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raul F. Argilagos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016566536","display_name":"Kit S. Lam","orcid":"https://orcid.org/0000-0002-3076-6969","observed_orcids":["https://orcid.org/0000-0002-3076-6969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kit Lam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059642198","display_name":"William T. Kerr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William T. Kerr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014680448","display_name":"Hong-Gong Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-Gong Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103061547","display_name":"William S. Dalton","orcid":"https://orcid.org/0000-0001-9417-2599","observed_orcids":["https://orcid.org/0000-0001-9417-2599"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William S. Dalton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054463097","display_name":"Lori Hazlehurst","orcid":"https://orcid.org/0000-0001-7040-4084","observed_orcids":["https://orcid.org/0000-0001-7040-4084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lori A. Hazlehurst","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6348000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6348000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.3174000084400177,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d-amino-acid-peptides","display_name":"D-amino acid peptides","score":0.8479999899864197},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9520000219345093},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9150000214576721},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9229999780654907},{"id":"https://openalex.org/keywords/fibronectin-adhesion","display_name":"fibronectin adhesion","score":0.8050000071525574},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5370000004768372},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.765999972820282},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.8095746040344238},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.6906254887580872},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6728378534317017},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5953296422958374},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5742828845977783},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47861260175704956},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4534265995025635},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4139004647731781},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3908279538154602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3540113866329193},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24076518416404724}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.c.6531617","doi":"https://doi.org/10.1158/1535-7163.c.6531617","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6531617","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6531617","doi":"https://doi.org/10.1158/1535-7163.c.6531617","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6531617","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2137878070","https://openalex.org/W4362478643","https://openalex.org/W2142585396","https://openalex.org/W2334344757","https://openalex.org/W180027602","https://openalex.org/W2327997691","https://openalex.org/W2561168083","https://openalex.org/W2105204735","https://openalex.org/W2909640381","https://openalex.org/W2063714802"],"abstract_inverted_index":{"Abstract":[0],"HYD1":[1,40,84,121],"is":[2],"a":[3,48,155],"D\u2013amino":[4],"acid":[5],"peptide":[6],"that":[7,27,153,179],"was":[8,54,129],"previously":[9],"shown":[10,59],"to":[11,18,30,38,131,137,151],"inhibit":[12],"adhesion":[13,32],"of":[14,33,70,100,105,144,176,199],"prostate":[15],"cancer":[16],"cells":[17,37,46,163],"the":[19,98,103,112,142],"extracellular":[20],"matrix.":[21],"In":[22],"this":[23],"study,":[24],"we":[25],"show":[26,152],"in":[28,44,56,63,77,89,125,201,206],"addition":[29],"inhibiting":[31],"multiple":[34],"myeloma":[35],"(MM)":[36],"fibronectin,":[39],"induces":[41],"cell":[42,52,91,138,145,185,188,204],"death":[43,53,92,186,205],"MM":[45,162,207],"as":[47,58,171,173],"single":[49],"agent.":[50],"HYD1-induced":[51,165,170,202],"necrotic":[55,203],"nature":[57],"by:":[60],"(a)":[61],"decrease":[62],"mitochondrial":[64],"membrane":[65],"potential":[66],"(\u0394\u03c8m),":[67],"(b)":[68],"loss":[69],"total":[71],"cellular":[72],"ATP,":[73],"and":[74,108,187],"(c)":[75],"increase":[76],"reactive":[78],"oxygen":[79],"species":[80],"(ROS)":[81],"production.":[82],"Moreover,":[83],"treatment":[85],"does":[86],"not":[87,96],"result":[88],"apoptotic":[90],"because":[93],"it":[94,116],"did":[95,115,122],"trigger":[97,183],"activation":[99],"caspases":[101],"or":[102],"release":[104],"apoptosis-inducing":[106],"factor":[107],"endonuclease":[109],"G":[110],"from":[111,164],"mitochondria,":[113],"nor":[114],"induce":[117],"double-stranded":[118],"DNA":[119],"breaks.":[120],"initiate":[123],"autophagy":[124,128],"cells;":[126],"however,":[127],"found":[130],"be":[132],"an":[133,196],"adaptive":[134],"response":[135],"contributing":[136],"survival":[139,189],"rather":[140],"than":[141],"cause":[143],"death.":[146,166],"We":[147],"were":[148],"further":[149],"able":[150],"N-acetyl-L-cysteine,":[154],"thiol-containing":[156],"free":[157],"radical":[158],"scavenger,":[159],"partially":[160],"protects":[161],"Additionally,":[167],"N-acetyl-L-cysteine":[168],"blocked":[169],"well":[172],"basal":[174],"levels":[175],"autophagy,":[177],"suggesting":[178],"ROS":[180,200],"can":[181],"potentially":[182],"both":[184],"pathways.":[190],"Taken":[191],"together,":[192],"our":[193],"data":[194],"describe":[195],"important":[197],"role":[198],"cells.":[208],"[Mol":[209],"Cancer":[210],"Ther":[211],"2009;8(8):2441\u201351]":[212]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-04-05T00:00:00"}
