{"id":"https://openalex.org/W4361958910","doi":"https://doi.org/10.1158/1078-0432.c.6518109.v1","title":"Data from Early G1 Cyclin-Dependent Kinases as Prognostic Markers and Potential Therapeutic Targets in Esophageal Adenocarcinoma","display_name":"Data from Early G1 Cyclin-Dependent Kinases as Prognostic Markers and Potential Therapeutic Targets in Esophageal Adenocarcinoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361958910","doi":"https://doi.org/10.1158/1078-0432.c.6518109.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6518109.v1","doi":"https://doi.org/10.1158/1078-0432.c.6518109.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6518109.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6518109.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Amin Ismail","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amin Ismail","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108217468","display_name":"Santhoshi Bandla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santhoshi Bandla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006421949","display_name":"Marie R\u00e9veiller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie Reveiller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038121589","display_name":"Liana M Toia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liana Toia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044137274","display_name":"Zhongren Zhou","orcid":"https://orcid.org/0000-0002-6977-8414","observed_orcids":["https://orcid.org/0000-0002-6977-8414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhongren Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017526826","display_name":"William E. Gooding","orcid":"https://orcid.org/0000-0001-9070-3559","observed_orcids":["https://orcid.org/0000-0001-9070-3559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William E. Gooding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054196266","display_name":"Irina Kalatskaya","orcid":"https://orcid.org/0000-0002-1663-859X","observed_orcids":["https://orcid.org/0000-0002-1663-859X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irina Kalatskaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052076713","display_name":"Lincoln David Stein","orcid":"https://orcid.org/0000-0002-1983-4588","observed_orcids":["https://orcid.org/0000-0002-1983-4588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lincoln Stein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044112892","display_name":"Mary D\u2019Souza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary D'Souza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021970250","display_name":"Virginia Ruth Litle","orcid":"https://orcid.org/0000-0002-3107-688X","observed_orcids":["https://orcid.org/0000-0002-3107-688X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Virginia R. Litle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020843186","display_name":"Jeffrey H. Peters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey H. Peters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035230452","display_name":"Arjun Pennathur","orcid":"https://orcid.org/0000-0001-7937-7991","observed_orcids":["https://orcid.org/0000-0001-7937-7991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arjun Pennathur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005631181","display_name":"James D. Luketich","orcid":"https://orcid.org/0000-0002-6578-6169","observed_orcids":["https://orcid.org/0000-0002-6578-6169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James D. Luketich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055942274","display_name":"Tony E. Godfrey","orcid":"https://orcid.org/0000-0002-3283-6983","observed_orcids":["https://orcid.org/0000-0002-3283-6983"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tony E. Godfrey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.03579999879002571,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/cdk6","display_name":"CDK6","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cdk4","display_name":"CDK4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.9789999723434448},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8960000276565552},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.8690000176429749},{"id":"https://openalex.org/keywords/prb-pathway","display_name":"pRb pathway","score":0.8500000238418579},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.7329999804496765},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.8349999785423279},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C199649820","wikidata":"https://www.wikidata.org/wiki/Q14911762","display_name":"Cyclin-dependent kinase 6","level":5,"score":0.6853698492050171},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.49088388681411743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47099846601486206},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46370843052864075},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.46317699551582336},{"id":"https://openalex.org/C2778589982","wikidata":"https://www.wikidata.org/wiki/Q808892","display_name":"Barrett's esophagus","level":4,"score":0.44218599796295166},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3520553708076477},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.3372719883918762},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2962709665298462},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2570226192474365},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2552613615989685},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15093085169792175},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.11229979991912842}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6518109.v1","doi":"https://doi.org/10.1158/1078-0432.c.6518109.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6518109.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6518109.v1","doi":"https://doi.org/10.1158/1078-0432.c.6518109.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6518109.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2162812530","https://openalex.org/W2327696017","https://openalex.org/W2331132958","https://openalex.org/W2035201046","https://openalex.org/W2030193407","https://openalex.org/W1989574877","https://openalex.org/W1683179340","https://openalex.org/W2092645267","https://openalex.org/W2016369708","https://openalex.org/W2112473227"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Chromosomal":[2],"gain":[3],"at":[4,131],"7q21":[5,53,64,76,92,227],"is":[6,162,193,223],"a":[7,25,44,85,163,249],"frequent":[8],"event":[9,16],"in":[10,24,80,113,242],"esophageal":[11],"adenocarcinoma":[12],"(EAC).":[13],"However,":[14],"this":[15,254],"has":[17],"not":[18],"been":[19],"mapped":[20],"with":[21,32,84,96,122,150],"fine":[22,50],"resolution":[23],"large":[26],"EAC":[27,187,210],"cohort,":[28],"and":[29,35,60,66,99,145,159,189,203,206,229,233,238],"its":[30,67],"association":[31],"clinical":[33],"endpoints":[34],"functional":[36,61],"relevance":[37],"are":[38,182,235],"unclear.":[39],"Experimental":[40],"Design:":[41],"We":[42,219],"used":[43],"cohort":[45],"of":[46,63,74,82,101,147,156,166,173,186,200,209,214,226],"116":[47],"patients":[48],"to":[49],"map":[51],"the":[52,75,110,114,132,136,197,215,224],"amplification":[54,65,93,127,144,228],"using":[55],"SNP":[56],"microarrays.":[57],"Prognostic":[58],"significance":[59],"role":[62],"gene":[68,102,112],"expression":[69,103,118,146],"were":[70],"explored.":[71],"Results:":[72],"Amplification":[73],"region":[77,134],"was":[78,94,119,129],"observed":[79,130],"35%":[81],"tumors":[83],"focal,":[86],"minimal":[87,115],"amplicon":[88,116],"containing":[89,135],"six":[90],"genes.":[91],"associated":[95,121],"poor":[97,123,151],"survival":[98,167],"analysis":[100],"identified":[104],"cyclin-dependent":[105,139],"kinase":[106,140,198],"6":[107],"(CDK6)":[108],"as":[109],"only":[111],"whose":[117],"also":[120],"survival.":[124,152],"A":[125,153],"low-level":[126],"(10%)":[128],"12q13":[133],"CDK6":[137,158,176,222,234],"homologue":[138],"4":[141],"(CDK4).":[142],"Both":[143],"CDK4":[148,160,174,232],"correlated":[149],"combined":[154],"model":[155],"both":[157,201,231],"expressions":[161],"superior":[164],"predictor":[165],"than":[168],"either":[169],"alone.":[170],"Specific":[171],"knockdown":[172],"and/or":[175],"by":[177],"siRNAs":[178],"shows":[179],"that":[180,190,221,230],"they":[181],"required":[183],"for":[184,253],"proliferation":[185,205],"cells":[188,211],"their":[191],"function":[192],"additive.":[194],"PD-0332991":[195],"targets":[196],"activity":[199],"molecules":[202,246],"suppresses":[204],"anchorage":[207],"independence":[208],"through":[212],"activation":[213],"pRB":[216],"pathway.":[217],"Conclusions:":[218],"suggest":[220],"driver":[225],"prognostic":[236],"markers":[237],"bona":[239],"fide":[240],"oncogenes":[241],"EAC.":[243],"Targeting":[244],"these":[245],"may":[247],"constitute":[248],"viable":[250],"new":[251],"therapy":[252],"disease.":[255],"Clin":[256],"Cancer":[257],"Res;":[258],"17(13);":[259],"4513\u201322.":[260],"\u00a92011":[261],"AACR.":[262]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2023-04-05T00:00:00"}
