{"id":"https://openalex.org/W4361958792","doi":"https://doi.org/10.1158/1078-0432.c.6522824.v1","title":"Data from HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma","display_name":"Data from HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361958792","doi":"https://doi.org/10.1158/1078-0432.c.6522824.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6522824.v1","doi":"https://doi.org/10.1158/1078-0432.c.6522824.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6522824.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6522824.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hong Zheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Zheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112124761","display_name":"Weipeng Zhao","orcid":"https://orcid.org/0000-0002-7909-9490","observed_orcids":["https://orcid.org/0000-0002-7909-9490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weipeng Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100864417","display_name":"Cihui Yan","orcid":"https://orcid.org/0000-0002-9391-0403","observed_orcids":["https://orcid.org/0000-0002-9391-0403"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cihui Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091743959","display_name":"Crystina C. Watson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Crystina C. Watson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025351008","display_name":"Michael T. Massengill","orcid":"https://orcid.org/0000-0003-0408-6596","observed_orcids":["https://orcid.org/0000-0003-0408-6596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Massengill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101108480","display_name":"Mengyu Xie","orcid":"https://orcid.org/0009-0009-3653-6636","observed_orcids":["https://orcid.org/0009-0009-3653-6636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mengyu Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059727935","display_name":"Chris Massengill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris Massengill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111712584","display_name":"David R. Noyes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David R. Noyes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007221296","display_name":"Gary V. Martinez","orcid":"https://orcid.org/0000-0002-6204-8363","observed_orcids":["https://orcid.org/0000-0002-6204-8363"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary V. Martinez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028266454","display_name":"Roha Afzal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roha Afzal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100709550","display_name":"Zhihua Chen","orcid":"https://orcid.org/0000-0002-4390-7636","observed_orcids":["https://orcid.org/0000-0002-4390-7636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhihua Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606004","display_name":"Xiubao Ren","orcid":"https://orcid.org/0000-0003-4137-2049","observed_orcids":["https://orcid.org/0000-0003-4137-2049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiubao Ren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046273815","display_name":"Scott Joseph Antonia","orcid":"https://orcid.org/0000-0002-6686-3824","observed_orcids":["https://orcid.org/0000-0002-6686-3824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott J. Antonia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064494204","display_name":"Eric B. Haura","orcid":"https://orcid.org/0000-0003-3114-1909","observed_orcids":["https://orcid.org/0000-0003-3114-1909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric B. Haura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021009961","display_name":"Brian Ruffell","orcid":"https://orcid.org/0000-0002-3846-6872","observed_orcids":["https://orcid.org/0000-0002-3846-6872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Ruffell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032171890","display_name":"Amer A. Beg","orcid":"https://orcid.org/0000-0003-3834-774X","observed_orcids":["https://orcid.org/0000-0003-3834-774X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amer A. Beg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/romidepsin","display_name":"romidepsin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.847000002861023},{"id":"https://openalex.org/keywords/tumor-infiltrating-t-cells","display_name":"tumor-infiltrating T cells","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.652999997138977},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.7829999923706055},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6650000214576721},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2781462825","wikidata":"https://www.wikidata.org/wiki/Q7363205","display_name":"Romidepsin","level":5,"score":0.8585504293441772},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6479943990707397},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6432284116744995},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6078632473945618},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6015880703926086},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.49131861329078674},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45685723423957825},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.42210516333580017},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38602587580680847},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.3754405677318573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.290050745010376},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27765005826950073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14852285385131836},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08499264717102051},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.08070552349090576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6522824.v1","doi":"https://doi.org/10.1158/1078-0432.c.6522824.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6522824.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6522824.v1","doi":"https://doi.org/10.1158/1078-0432.c.6522824.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6522824.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2296591944","https://openalex.org/W2944327888","https://openalex.org/W7034435570","https://openalex.org/W4210548348","https://openalex.org/W4392722770","https://openalex.org/W2153162429","https://openalex.org/W4399133791","https://openalex.org/W3199817364","https://openalex.org/W4207066457","https://openalex.org/W4380030110"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"A":[2],"significant":[3],"limitation":[4],"of":[5,66,70,97,116,176,189,208,227],"checkpoint":[6],"blockade":[7,19,153,171,232],"immunotherapy":[8,41,72,154,219],"is":[9],"the":[10,64,128,149],"relatively":[11],"low":[12],"response":[13,150],"rate":[14],"(e.g.,":[15],"\u223c20%":[16],"with":[17,55,63,89,230],"PD-1":[18,90,152,170,231],"in":[20,39,78,87,120,131,155,164,191,196],"lung":[21,80,157,238],"cancer).":[22],"In":[23,200],"this":[24],"study,":[25],"we":[26,133],"tested":[27,77],"whether":[28],"strategies":[29],"that":[30,108,205,225],"increase":[31],"T-cell":[32,60,118,139,193,209],"infiltration":[33],"to":[34,50,58,101,151],"tumors":[35,98],"can":[36],"be":[37],"efficacious":[38],"enhancing":[40,218],"response.":[42,73,220],"Experimental":[43],"Design:":[44],"We":[45,106],"performed":[46],"an":[47,56],"unbiased":[48],"screen":[49],"identify":[51],"FDA-approved":[52],"oncology":[53],"agents":[54,68,75,85],"ability":[57],"enhance":[59],"chemokine":[61,136,194,210],"expression":[62,115,195,211],"goal":[65],"identifying":[67],"capable":[69],"augmenting":[71],"Identified":[74],"were":[76],"multiple":[79,117,156,197],"tumor":[81,143,158],"models":[82],"as":[83],"single":[84],"and":[86,94,124,141,169],"combination":[88,226],"blockade.":[91],"Additional":[92],"molecular":[93],"cellular":[95],"analysis":[96],"was":[99],"used":[100],"define":[102],"underlying":[103],"mechanisms.":[104],"Results:":[105],"found":[107],"histone":[109],"deacetylase":[110],"(HDAC)":[111],"inhibitors":[112,229],"(HDACi)":[113],"increased":[114,135],"chemokines":[119],"cancer":[121,239],"cells,":[122],"macrophages,":[123],"T":[125,178],"cells.":[126,179],"Using":[127],"HDACi":[129],"romidepsin":[130,146,168],"vivo,":[132],"observed":[134],"expression,":[137],"enhanced":[138,148,174],"infiltration,":[140],"T-cell\u2013dependent":[142],"regression.":[144],"Importantly,":[145],"significantly":[147,173],"models,":[159],"including":[160],"nearly":[161],"complete":[162],"rejection":[163],"two":[165],"models.":[166],"Combined":[167],"also":[172],"activation":[175],"tumor-infiltrating":[177],"Conclusions:":[180],"These":[181],"results":[182,223],"provide":[183],"evidence":[184],"for":[185,217,237],"a":[186,213,234],"novel":[187,215],"role":[188],"HDACs":[190],"modulating":[192],"cell":[198],"types.":[199],"addition,":[201],"our":[202],"findings":[203],"indicate":[204],"pharmacologic":[206],"induction":[207],"represents":[212,233],"conceptually":[214],"approach":[216],"Finally,":[221],"these":[222],"suggest":[224],"HDAC":[228],"promising":[235],"strategy":[236],"treatment.":[240],"Clin":[241],"Cancer":[242],"Res;":[243],"22(16);":[244],"4119\u201332.":[245],"\u00a92016":[246],"AACR.":[247]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2023-04-05T00:00:00"}
