{"id":"https://openalex.org/W4361958700","doi":"https://doi.org/10.1158/1078-0432.c.6522263.v1","title":"Data from HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells","display_name":"Data from HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361958700","doi":"https://doi.org/10.1158/1078-0432.c.6522263.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6522263.v1","doi":"https://doi.org/10.1158/1078-0432.c.6522263.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6522263.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6522263.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091354371","display_name":"Nadire Duru","orcid":"https://orcid.org/0000-0001-9066-8191","observed_orcids":["https://orcid.org/0000-0001-9066-8191"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadire Duru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ming Fan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015508635","display_name":"Demet Candas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Demet Candas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084041568","display_name":"Cheikh Menaa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheikh Menaa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037585336","display_name":"Hsin-Chen Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hsin-Chen Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085171535","display_name":"Danupon Nantajit","orcid":"https://orcid.org/0000-0003-1368-714X","observed_orcids":["https://orcid.org/0000-0003-1368-714X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danupon Nantajit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046290894","display_name":"Yunfei Wen","orcid":"https://orcid.org/0000-0001-5313-1117","observed_orcids":["https://orcid.org/0000-0001-5313-1117"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yunfei Wen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023711566","display_name":"Kai Xiao","orcid":"https://orcid.org/0000-0002-0402-8276","observed_orcids":["https://orcid.org/0000-0002-0402-8276"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073028234","display_name":"Angela Eldridge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela Eldridge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085787524","display_name":"Brett A. Chromy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brett A. Chromy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780836","display_name":"Shiyong Li","orcid":"https://orcid.org/0000-0003-0416-526X","observed_orcids":["https://orcid.org/0000-0003-0416-526X","https://orcid.org/0000-0002-7052-5203","https://orcid.org/0000-0001-7442-1826"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiyong Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044316011","display_name":"Douglas R. Spitz","orcid":"https://orcid.org/0000-0002-1254-8765","observed_orcids":["https://orcid.org/0000-0002-1254-8765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas R. Spitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016566536","display_name":"Kit S. Lam","orcid":"https://orcid.org/0000-0002-3076-6969","observed_orcids":["https://orcid.org/0000-0002-3076-6969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kit S. Lam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059956218","display_name":"Max S. Wicha","orcid":"https://orcid.org/0000-0003-4180-7727","observed_orcids":["https://orcid.org/0000-0003-4180-7727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Max S. Wicha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023118874","display_name":"Jian Jian Li","orcid":"https://orcid.org/0000-0003-3694-9675","observed_orcids":["https://orcid.org/0000-0003-3694-9675"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Jian Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.10350000113248825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-stem-cells","display_name":"breast cancer stem cells","score":0.9369999766349792},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.921999990940094},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.9879999756813049},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/breast-cancer-recurrence","display_name":"breast cancer recurrence","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.8119999766349792},{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase","display_name":"aldehyde dehydrogenase","score":0.9160000085830688},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.671999990940094},{"id":"https://openalex.org/keywords/protein-expression-profiling","display_name":"protein expression profiling","score":0.7020000219345093},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.6110000014305115},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.7540000081062317},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.45899999141693115},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.8069999814033508},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":1.0},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.6530443429946899},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.6489031910896301},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5648306608200073},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.4568089544773102},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44589826464653015},{"id":"https://openalex.org/C2779492189","wikidata":"https://www.wikidata.org/wiki/Q1190762","display_name":"CD24","level":4,"score":0.43718022108078003},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.397593230009079},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3671918511390686},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3622671961784363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33553051948547363},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.29678863286972046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26087188720703125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2128155529499054},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1932069957256317},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6522263.v1","doi":"https://doi.org/10.1158/1078-0432.c.6522263.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6522263.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6522263.v1","doi":"https://doi.org/10.1158/1078-0432.c.6522263.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6522263.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2155509815","https://openalex.org/W2332804701","https://openalex.org/W1486733737","https://openalex.org/W2887147801","https://openalex.org/W4322627707","https://openalex.org/W2779195779","https://openalex.org/W3201724673","https://openalex.org/W2287006027","https://openalex.org/W2972991629","https://openalex.org/W2888944160"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"To":[2],"understand":[3],"the":[4,158,236,246,257],"role":[5],"of":[6,157,166,201,227,249],"HER2-associated":[7,209],"signaling":[8,118,241],"network":[9,119,229,242],"in":[10,54,82,93,148,188,215],"breast":[11,18,24,38,49,87,174,260],"cancer":[12,19,50,88,175],"stem":[13],"cells":[14,20,52,131,160,179],"(BCSC)":[15],"using":[16],"radioresistant":[17],"and":[21,53,62,73,85,107,116,138,147,155,182,199,221],"clinical":[22],"recurrent":[23,36,86,189],"cancers":[25],"to":[26,255],"evaluate":[27],"HER2-targeted":[28],"therapy":[29],"as":[30],"a":[31,207],"tumor":[32,144,216],"eliminating":[33],"strategy":[34],"for":[35,245],"HER2\u2212/low":[37,259],"cancers.":[39],"Experimental":[40],"Design:":[41],"HER2-expressing":[42],"BCSCs":[43,97,205,250],"(HER2+/CD44+/CD24\u2212/low)":[44],"were":[45,64,161,184],"isolated":[46],"from":[47],"radiation-treated":[48],"MCF7":[51,57],"vivo":[55,149],"irradiated":[56],"xenograft":[58],"tumors.":[59],"Tumor":[60],"aggressiveness":[61,139],"radioresistance":[63,156],"analyzed":[65,81],"by":[66,122,141,164],"gap":[67],"filling,":[68],"Matrigel":[69,142],"invasion,":[70,143],"tumor-sphere":[71],"formation,":[72,146],"clonogenic":[74],"survival":[75],"assays.":[76],"The":[77,151],"HER2/CD44":[78],"feature":[79,226],"was":[80,98,120,230],"40":[83],"primary":[84,192],"specimens.":[89],"Protein":[90],"expression":[91],"profiling":[92],"HER2+/CD44+/CD24\u2212/low":[94,130,159,202],"versus":[95,203],"HER2\u2212/CD44+/CD24\u2212/low":[96,204],"conducted":[99],"with":[100,127],"two-dimensional":[101],"difference":[102],"gel":[103],"electrophoresis":[104],"(2-D":[105],"DIGE)":[106],"high-performance":[108],"liquid":[109],"chromatography":[110],"tandem":[111],"mass":[112],"spectrometry":[113],"(HPLC/MS-MS)":[114],"analysis":[115],"HER2-mediated":[117,239],"generated":[121],"MetaCore":[123],"program.":[124],"Results:":[125],"Compared":[126],"HER2-negative":[128],"BCSCs,":[129],"showed":[132],"elevated":[133],"aldehyde":[134],"dehydrogenase":[135],"(ALDH)":[136],"activity":[137],"tested":[140],"sphere":[145],"tumorigenesis.":[150],"enhanced":[152],"aggressive":[153,247],"phenotype":[154,248],"markedly":[162],"reduced":[163],"inhibition":[165],"HER2":[167,181],"via":[168],"siRNA":[169],"or":[170],"Herceptin":[171],"treatments.":[172],"Clinical":[173],"specimens":[176],"revealed":[177],"that":[178,238,251],"coexpressing":[180],"CD44":[183],"more":[185],"frequently":[186],"detected":[187],"(84.6%)":[190],"than":[191],"tumors":[193],"(57.1%).":[194],"In":[195],"addition,":[196],"2-D":[197],"DIGE":[198],"HPLC/MS-MS":[200],"reported":[206],"unique":[208],"protein":[210],"profile":[211],"including":[212],"effectors":[213],"involved":[214],"metastasis,":[217],"apoptosis,":[218],"mitochondrial":[219],"function,":[220],"DNA":[222],"repair.":[223],"A":[224],"specific":[225],"HER2\u2013STAT3":[228],"identified.":[231],"Conclusion:":[232],"This":[233],"study":[234],"provides":[235],"evidence":[237],"prosurvival":[240],"is":[243],"responsible":[244],"could":[252],"be":[253],"targeted":[254],"control":[256],"therapy-resistant":[258],"cancer.":[261],"Clin":[262],"Cancer":[263],"Res;":[264],"18(24);":[265],"6634\u201347.":[266],"\u00a92012":[267],"AACR.":[268]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-05T00:00:00"}
