{"id":"https://openalex.org/W4361958656","doi":"https://doi.org/10.1158/1078-0432.c.6529167.v1","title":"Data from Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma","display_name":"Data from Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361958656","doi":"https://doi.org/10.1158/1078-0432.c.6529167.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6529167.v1","doi":"https://doi.org/10.1158/1078-0432.c.6529167.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6529167.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6529167.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025351354","display_name":"Benjamin M. Ellingson","orcid":"https://orcid.org/0000-0002-2764-6640","observed_orcids":["https://orcid.org/0000-0002-2764-6640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin M. Ellingson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2764-6640","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030410351","display_name":"Jingwen Yao","orcid":"https://orcid.org/0000-0002-8828-1841","observed_orcids":["https://orcid.org/0000-0002-8828-1841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingwen Yao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084168615","display_name":"Catalina Raymond","orcid":"https://orcid.org/0000-0003-2757-439X","observed_orcids":["https://orcid.org/0000-0003-2757-439X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catalina Raymond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004206249","display_name":"David A. Nathanson","orcid":"https://orcid.org/0000-0002-4919-9159","observed_orcids":["https://orcid.org/0000-0002-4919-9159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Nathanson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067837083","display_name":"Ararat Chakhoyan","orcid":"https://orcid.org/0000-0001-9447-495X","observed_orcids":["https://orcid.org/0000-0001-9447-495X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ararat Chakhoyan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jeremy Simpson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy Simpson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062059537","display_name":"James Stuart Garner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James S. Garner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103885960","display_name":"Alan G. Olivero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan G. Olivero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110236","display_name":"Lars U. Mueller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lars U. Mueller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031165814","display_name":"Jordi Ahnert Rodon","orcid":"https://orcid.org/0000-0001-6467-3632","observed_orcids":["https://orcid.org/0000-0001-6467-3632","https://orcid.org/0000-0003-2234-5248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordi Rodon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082835319","display_name":"Elizabeth Robins Gerstner","orcid":"https://orcid.org/0000-0003-2382-3838","observed_orcids":["https://orcid.org/0000-0003-2382-3838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Gerstner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063511816","display_name":"Timothy Francis Cloughesy","orcid":"https://orcid.org/0000-0002-8656-7483","observed_orcids":["https://orcid.org/0000-0002-8656-7483"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy F. Cloughesy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021656597","display_name":"Patrick Yung Wen","orcid":"https://orcid.org/0000-0002-0774-7700","observed_orcids":["https://orcid.org/0000-0002-0774-7700","https://orcid.org/0000-0003-3224-3042","https://orcid.org/0000-0002-2452-0540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Y. Wen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.08749999850988388,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-high-grade-glioma","display_name":"recurrent high-grade glioma","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pharmacokinetic-prediction","display_name":"pharmacokinetic prediction","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pi3k-mtor-inhibitors","display_name":"PI3K/mTOR inhibitors","score":0.8199999928474426},{"id":"https://openalex.org/keywords/18f-fdg-pet","display_name":"18F-FDG PET","score":0.8149999976158142},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/apparent-diffusion-coefficient","display_name":"apparent diffusion coefficient","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ktrans","display_name":"Ktrans","score":0.6639999747276306},{"id":"https://openalex.org/keywords/relative-cerebral-blood-volume","display_name":"relative cerebral blood volume","score":0.953000009059906},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6930000185966492},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5460919141769409},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5404580235481262},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5033456683158875},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.45303285121917725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44467923045158386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3841474652290344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3137897253036499},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2789132595062256},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.2530922591686249},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16691356897354126},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6529167.v1","doi":"https://doi.org/10.1158/1078-0432.c.6529167.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6529167.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6529167.v1","doi":"https://doi.org/10.1158/1078-0432.c.6529167.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6529167.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3015396224","https://openalex.org/W2986587395","https://openalex.org/W2999607433","https://openalex.org/W4251526733","https://openalex.org/W2899558373","https://openalex.org/W2985046962","https://openalex.org/W2757101206","https://openalex.org/W2519363128","https://openalex.org/W2745731372","https://openalex.org/W2036391644"],"abstract_inverted_index":{"AbstractPurpose:":[0],"GDC-0084":[1,70],"is":[2],"an":[3,97,176],"oral,":[4],"brain-penetrant":[5],"small-molecule":[6],"inhibitor":[7],"of":[8,69,126,232,240],"PI3K":[9],"and":[10,19,37,49,96,112,139,153,182,199,204],"mTOR.":[11],"Because":[12],"these":[13],"two":[14],"targets":[15],"alter":[16],"tumor":[17,91,107],"vascularity":[18],"metabolism,":[20],"respectively,":[21],"we":[22],"hypothesized":[23],"multiparametric":[24,166,219],"MR-PET":[25,53,167,220],"could":[26],"be":[27,235],"used":[28],"to":[29,57,143,171,228],"quantify":[30],"the":[31,229],"response,":[32],"estimate":[33,144],"pharmacokinetic":[34],"(PK)":[35],"parameters,":[36],"predict":[38,172],"progression-free":[39],"survival":[40],"(PFS)":[41],"in":[42,61,72,89,99,128],"patients":[43,74,174,193],"with":[44,75,86,121,175,192,194],"recurrent":[45,76],"malignant":[46,77],"gliomas.":[47],"Patients":[48],"Methods:":[50],"Multiparametric":[51],"advanced":[52],"imaging":[54,168,221],"was":[55,84,141],"performed":[56],"evaluate":[58],"physiologic":[59,225],"response":[60,169],"a":[62,87,195],"first-in-man,":[63],"multicenter,":[64],"phase":[65,245],"I,":[66],"dose-escalation":[67],"study":[68,213],"(NCT01547546)":[71],"47":[73],"glioma.":[78],"Results:":[79],"Measured":[80],"maximum":[81],"concentration":[82,198],"(Cmax)":[83],"associated":[85],"decrease":[88],"enhancing":[90],"volume":[92,116],"(P":[93,201],"=":[94,104,148,158,202,206],"0.0287)":[95],"increase":[98],"fractional":[100],"anisotropy":[101],"(FA;":[102],"P":[103,150,160,205],"0.0418).":[105],"Posttreatment":[106],"volume,":[108],"18F-FDG":[109,129],"uptake,":[110,131],"Ktrans,":[111,137],"relative":[113],"cerebral":[114],"blood":[115],"(rCBV)":[117],"were":[118],"all":[119],"correlated":[120],"Cmax.":[122],"A":[123],"linear":[124],"combination":[125],"change":[127],"PET":[130],"apparent":[132],"diffusion":[133],"coefficient":[134],"(ADC),":[135],"FA,":[136],"vp,":[138],"rCBV":[140],"able":[142],"both":[145],"Cmax":[146,178],"(R2":[147],"0.4113;":[149],"<":[151,161],"0.0001)":[152],"drug":[154,230],"exposure":[155,200],"(AUC;":[156],"R2":[157],"0.3481;":[159],"0.0001).":[162],"Using":[163],"this":[164,212],"composite":[165,215],"biomarker":[170],"PK,":[173],"estimated":[177,197],">":[179,184],"0.1":[180],"\u03bcmol/L":[181],"AUC":[183],"1.25":[185],"\u03bcmol/L*hour":[186],"demonstrated":[187],"significantly":[188],"longer":[189],"PFS":[190],"compared":[191],"lower":[196],"0.0039":[203],"0.0296,":[207],"respectively).":[208],"Conclusions:":[209],"Results":[210],"from":[211,218],"suggest":[214],"biomarkers":[216],"created":[217],"targeting":[222],"metabolic":[223],"and/or":[224],"processes":[226],"specific":[227],"mechanism":[231],"action":[233],"may":[234],"useful":[236],"for":[237,243],"subsequent":[238],"evaluation":[239],"treatment":[241],"efficacy":[242],"larger":[244],"II\u2013III":[246],"studies.":[247]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
