{"id":"https://openalex.org/W4361951995","doi":"https://doi.org/10.1158/1078-0432.c.6524816.v1","title":"Data from Crizotinib Synergizes with Chemotherapy in Preclinical Models of Neuroblastoma","display_name":"Data from Crizotinib Synergizes with Chemotherapy in Preclinical Models of Neuroblastoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361951995","doi":"https://doi.org/10.1158/1078-0432.c.6524816.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6524816.v1","doi":"https://doi.org/10.1158/1078-0432.c.6524816.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6524816.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6524816.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053226567","display_name":"Kateryna Krytska","orcid":"https://orcid.org/0009-0009-8402-8687","observed_orcids":["https://orcid.org/0009-0009-8402-8687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kateryna Krytska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019240347","display_name":"Hannah T. Ryles","orcid":"https://orcid.org/0000-0001-5126-9075","observed_orcids":["https://orcid.org/0000-0001-5126-9075"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hannah T. Ryles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102864493","display_name":"Renata Sano","orcid":"https://orcid.org/0000-0001-9630-3388","observed_orcids":["https://orcid.org/0000-0001-9630-3388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renata Sano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068529122","display_name":"Pichai Raman","orcid":"https://orcid.org/0000-0001-6948-2157","observed_orcids":["https://orcid.org/0000-0001-6948-2157"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pichai Raman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040149772","display_name":"Nicole R. Infarinato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole R. Infarinato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904793","display_name":"Theodore D. Hansel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theodore D. Hansel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072369293","display_name":"Monish Ram Makena","orcid":"https://orcid.org/0000-0002-4068-7375","observed_orcids":["https://orcid.org/0000-0002-4068-7375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monish R. Makena","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110200","display_name":"Michael Meansup Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael M. Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058354009","display_name":"C. Patrick Reynolds","orcid":"https://orcid.org/0000-0002-2827-8536","observed_orcids":["https://orcid.org/0000-0002-2827-8536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Patrick Reynolds","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030496565","display_name":"Ya\u00ebl P. Moss\u00e9","orcid":"https://orcid.org/0000-0002-3463-0399","observed_orcids":["https://orcid.org/0000-0002-3463-0399"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yael P. Moss\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crizotinib","display_name":"crizotinib","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/alk-mutations","display_name":"ALK mutations","score":0.8859999775886536},{"id":"https://openalex.org/keywords/alk-inhibitors","display_name":"ALK inhibitors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/topotecan","display_name":"topotecan","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":1.0},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6620000004768372},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6890000104904175},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8619999885559082},{"id":"https://openalex.org/keywords/caspase-dependent-apoptosis","display_name":"caspase-dependent apoptosis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/alk-amplification","display_name":"ALK amplification","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.9752495288848877},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6051415801048279},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5903046131134033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39372965693473816},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.33299338817596436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3322516083717346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18262073397636414},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.10933342576026917},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06872367858886719},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6524816.v1","doi":"https://doi.org/10.1158/1078-0432.c.6524816.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6524816.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6524816.v1","doi":"https://doi.org/10.1158/1078-0432.c.6524816.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6524816.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2193255355","https://openalex.org/W2728549817","https://openalex.org/W4361970327","https://openalex.org/W4361920270","https://openalex.org/W1559319547","https://openalex.org/W2567312428","https://openalex.org/W4362512049","https://openalex.org/W3127273031","https://openalex.org/W4361815831","https://openalex.org/W2404235140"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"The":[2,17,74],"presence":[3],"of":[4,19,45,50,61,76,110,121,221,229],"an":[5],"ALK":[6,20,32,56,90,132,180,209,214,231],"aberration":[7],"correlates":[8],"with":[9,14,88,95,138,146,151,179,188,198,226],"inferior":[10],"survival":[11],"for":[12,67,108,236],"patients":[13,53,197],"high-risk":[15,199],"neuroblastoma.":[16],"emergence":[18],"inhibitors":[21],"such":[22],"as":[23],"crizotinib":[24,38,46,93,141,149,171,187,222],"has":[25],"provided":[26],"novel":[27],"treatment":[28],"opportunities.":[29],"However,":[30],"certain":[31],"mutations":[33,136],"result":[34],"in":[35,52,144,175,193,203],"de":[36,212],"novo":[37],"resistance,":[39],"and":[40,63,83,97,104,116,119,156,166,211,223],"a":[41,48],"phase":[42],"I":[43],"trial":[44],"showed":[47,163],"lack":[49],"response":[51],"harboring":[54,128,206],"those":[55,135,145],"mutations.":[57,215],"Thus,":[58],"understanding":[59],"mechanisms":[60],"resistance":[62,139],"defining":[64],"circumvention":[65],"strategies":[66],"the":[68,129,227],"clinic":[69],"is":[70],"critical.":[71],"Experimental":[72],"Design:":[73],"sensitivity":[75,202],"human":[77],"neuroblastoma\u2013derived":[78],"cell":[79,81,117,177],"lines,":[80],"line\u2013derived,":[82],"patient-derived":[84],"xenograft":[85],"(PDX)":[86],"models":[87,205],"varying":[89],"statuses":[91],"to":[92,140],"combined":[94,150],"topotecan":[96],"cyclophosphamide":[98],"(topo/cyclo)":[99],"was":[100],"examined.":[101],"Cultured":[102],"cells":[103],"xenografts":[105,127],"were":[106],"evaluated":[107],"effects":[109],"these":[111],"drugs":[112],"on":[113],"proliferation,":[114],"signaling,":[115],"death,":[118],"assessment":[120],"synergy.":[122],"Results:":[123],"In":[124],"neuroblastoma":[125,176,200,238],"murine":[126],"most":[130],"common":[131],"mutations,":[133],"including":[134],"associated":[137],"(but":[142],"not":[143],"wild-type":[147],"ALK),":[148],"topo/cyclo":[152,162,173],"enhanced":[153],"tumor":[154],"responses":[155],"mouse":[157],"event-free":[158],"survival.":[159],"Crizotinib":[160],"+":[161],"synergistic":[164],"cytotoxicity":[165],"higher":[167],"caspase-dependent":[168],"apoptosis":[169],"than":[170],"or":[172,183],"alone":[174],"lines":[178],"aberrations":[181,210],"(mutation":[182],"amplification).":[184],"Conclusions:":[185],"Combining":[186],"chemotherapeutic":[189],"agents":[190],"commonly":[191],"used":[192],"treating":[194],"newly":[195],"diagnosed":[196],"restores":[201],"preclinical":[204],"both":[207],"sensitive":[208],"novo\u2013resistant":[213],"These":[216],"data":[217],"support":[218],"clinical":[219],"testing":[220],"conventional":[224],"chemotherapy":[225],"goal":[228],"integrating":[230],"inhibition":[232],"into":[233],"multiagent":[234],"therapy":[235],"ALK-aberrant":[237],"patients.":[239],"Clin":[240],"Cancer":[241],"Res;":[242],"22(4);":[243],"948\u201360.":[244],"\u00a92015":[245],"AACR.":[246]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}
