{"id":"https://openalex.org/W4361950952","doi":"https://doi.org/10.1158/1078-0432.c.6522171.v1","title":"Data from Coadministration of Epithelial Junction Opener JO-1 Improves the Efficacy and Safety of Chemotherapeutic Drugs","display_name":"Data from Coadministration of Epithelial Junction Opener JO-1 Improves the Efficacy and Safety of Chemotherapeutic Drugs","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361950952","doi":"https://doi.org/10.1158/1078-0432.c.6522171.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6522171.v1","doi":"https://doi.org/10.1158/1078-0432.c.6522171.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6522171.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6522171.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033918537","display_name":"Ines Beyer","orcid":"https://orcid.org/0000-0001-7468-4466","observed_orcids":["https://orcid.org/0000-0001-7468-4466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ines Beyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101854085","display_name":"Hua Cao","orcid":"https://orcid.org/0000-0003-1032-2719","observed_orcids":["https://orcid.org/0000-0003-1032-2719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Cao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jonas Persson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonas Persson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113478273","display_name":"Hui Song","orcid":"https://orcid.org/0000-0001-6804-3232","observed_orcids":["https://orcid.org/0000-0001-6804-3232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103253223","display_name":"Maximilian Richter","orcid":"https://orcid.org/0000-0002-7305-4224","observed_orcids":["https://orcid.org/0000-0002-7305-4224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maximilian Richter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015414714","display_name":"Qinghua Feng","orcid":"https://orcid.org/0009-0003-7265-2091","observed_orcids":["https://orcid.org/0009-0003-7265-2091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qinghua Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056305765","display_name":"Roma Yumul","orcid":"https://orcid.org/0009-0007-8504-2531","observed_orcids":["https://orcid.org/0009-0007-8504-2531","https://orcid.org/0000-0002-8680-5154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roma Yumul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113495719","display_name":"Ruan van Rensburg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruan van Rensburg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101754034","display_name":"Zongyi Li","orcid":"https://orcid.org/0000-0002-2637-0486","observed_orcids":["https://orcid.org/0000-0002-2637-0486"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zongyi Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060134012","display_name":"RONALD J. BERENSON","orcid":"https://orcid.org/0009-0005-4037-188X","observed_orcids":["https://orcid.org/0009-0005-4037-188X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald Berenson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072667047","display_name":"Darrick Carter","orcid":"https://orcid.org/0000-0001-5901-3402","observed_orcids":["https://orcid.org/0000-0001-5901-3402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darrick Carter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002537567","display_name":"Steve R. Roffler","orcid":"https://orcid.org/0000-0003-2543-7295","observed_orcids":["https://orcid.org/0000-0003-2543-7295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Roffler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028288310","display_name":"Charles W. Drescher","orcid":"https://orcid.org/0000-0002-6579-0416","observed_orcids":["https://orcid.org/0000-0002-6579-0416"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Drescher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029285661","display_name":"Andr\u00e9 Lieber","orcid":"https://orcid.org/0000-0001-6742-6266","observed_orcids":["https://orcid.org/0000-0001-6742-6266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Lieber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.14309999346733093,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.08619999885559082,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jo-1","display_name":"Jo-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/desmoglein-2","display_name":"desmoglein 2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/epithelial-junctions","display_name":"epithelial junctions","score":0.7739999890327454},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6240000128746033},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8240000009536743},{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.906000018119812},{"id":"https://openalex.org/keywords/liposomal-doxorubicin","display_name":"liposomal doxorubicin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":1.0},{"id":"https://openalex.org/keywords/tumor-penetration","display_name":"tumor penetration","score":0.40299999713897705},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7300000190734863},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5820000171661377},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.5289999842643738},{"id":"https://openalex.org/keywords/intestinal-toxicity","display_name":"intestinal toxicity","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5887496471405029},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.5835704803466797},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49580344557762146},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.4786021411418915},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4464247226715088},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.40877407789230347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14149653911590576}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6522171.v1","doi":"https://doi.org/10.1158/1078-0432.c.6522171.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6522171.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6522171.v1","doi":"https://doi.org/10.1158/1078-0432.c.6522171.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6522171.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2167038395","https://openalex.org/W2123363275","https://openalex.org/W4392726172","https://openalex.org/W2595088854","https://openalex.org/W2331060387","https://openalex.org/W2781529921","https://openalex.org/W2938431204","https://openalex.org/W2171180960","https://openalex.org/W2161248303","https://openalex.org/W7148663656"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Epithelial":[2],"junctions":[3,31],"between":[4],"tumor":[5],"cells":[6],"inhibit":[7],"the":[8,43,65,136,153,186,233,237],"penetration":[9],"of":[10,29,46,53,67,74,77,138,155,206,240],"anticancer":[11],"drugs":[12],"into":[13],"tumors.":[14,197],"We":[15],"previously":[16],"reported":[17],"on":[18,215],"recombinant":[19],"adenovirus":[20],"serotype":[21],"3\u2013derived":[22],"protein":[23],"(JO-1),":[24],"which":[25],"triggers":[26],"transient":[27,202],"opening":[28],"intercellular":[30],"in":[32,79,96,142,196,221],"epithelial":[33],"tumors":[34,129],"through":[35],"binding":[36],"to":[37,57,112,159,235],"desmoglein":[38],"2":[39],"(DSG2),":[40],"and":[41,92,104,141,172],"enhances":[42],"antitumor":[44,161],"effects":[45,177,214],"several":[47,82,143],"therapeutic":[48,238],"monoclonal":[49],"antibodies.":[50],"The":[51,72],"goal":[52],"this":[54],"study":[55],"was":[56,94],"evaluate":[58],"whether":[59],"JO-1":[60,78,108,134,148,164,193,207,230],"cotherapy":[61,231],"can":[62],"also":[63,121,150],"improve":[64,236],"efficacy":[66,137],"chemotherapeutic":[68,139,183],"drugs.":[69],"Experimental":[70],"Design:":[71],"effect":[73],"intravenous":[75,204],"application":[76],"combination":[80],"with":[81,118,128,182],"chemotherapy":[83],"drugs,":[84,140],"including":[85,169],"paclitaxel/Taxol,":[86],"nanoparticle":[87],"albumin\u2013bound":[88],"paclitaxel/Abraxane,":[89],"liposomal":[90],"doxorubicin/Doxil,":[91],"irinotecan/Camptosar,":[93],"tested":[95],"xenograft":[97],"models":[98,144],"for":[99,115,152,199],"breast,":[100],"colon,":[101],"ovarian,":[102],"gastric":[103],"lung":[105],"cancer.":[106],"Because":[107],"does":[109],"not":[110],"bind":[111],"mouse":[113,188],"cells,":[114],"safety":[116],"studies":[117],"JO-1,":[119],"we":[120,190],"used":[122],"human":[123],"DSG2":[124],"(hDSG2)":[125],"transgenic":[126],"mice":[127],"that":[130,178,192,229],"overexpressed":[131],"hDSG2.":[132],"Results:":[133],"increased":[135],"overcame":[145],"drug":[146,156],"resistance.":[147],"treatment":[149],"allowed":[151],"reduction":[154],"doses":[157],"required":[158],"achieve":[160],"effects.":[162],"Importantly,":[163],"coadmininstration":[165],"protected":[166],"normal":[167],"tissues,":[168],"bone":[170],"marrow":[171],"intestinal":[173],"epithelium,":[174],"against":[175],"toxic":[176],"are":[179],"normally":[180],"associated":[181],"agents.":[184],"Using":[185],"hDSG2-transgenic":[187,222],"model,":[189],"showed":[191],"predominantly":[194],"accumulates":[195],"Except":[198],"a":[200],"mild,":[201],"diarrhea,":[203],"injection":[205],"(2":[208],"mg/kg)":[209],"had":[210],"no":[211],"critical":[212],"side":[213],"other":[216],"tissues":[217],"or":[218],"hematologic":[219],"parameters":[220],"mice.":[223],"Conclusions:":[224],"Our":[225],"preliminary":[226],"data":[227],"suggest":[228],"has":[232],"potential":[234],"outcome":[239],"cancer":[241],"chemotherapy.":[242],"Clin":[243],"Cancer":[244],"Res;":[245],"18(12);":[246],"3340\u201351.":[247],"\u00a92012":[248],"AACR.":[249]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-05T00:00:00"}