{"id":"https://openalex.org/W4361950508","doi":"https://doi.org/10.1158/1078-0432.c.6533087","title":"Data from Design and Preclinical Evaluation of a Novel B7-H4\u2013Directed Antibody\u2013Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305","display_name":"Data from Design and Preclinical Evaluation of a Novel B7-H4\u2013Directed Antibody\u2013Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305","publication_year":2023,"publication_date":"2023-04-01","ids":{"openalex":"https://openalex.org/W4361950508","doi":"https://doi.org/10.1158/1078-0432.c.6533087"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6533087","doi":"https://doi.org/10.1158/1078-0432.c.6533087","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6533087","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6533087","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076745184","display_name":"Krista Kinneer","orcid":"https://orcid.org/0000-0002-5148-4848","observed_orcids":["https://orcid.org/0000-0002-5148-4848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krista Kinneer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5148-4848","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012180250","display_name":"Philipp Wortmann","orcid":"https://orcid.org/0000-0001-7325-3031","observed_orcids":["https://orcid.org/0000-0001-7325-3031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philipp Wortmann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7325-3031","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071770314","display_name":"Zachary Aaron Cooper","orcid":"https://orcid.org/0000-0003-1059-0940","observed_orcids":["https://orcid.org/0000-0003-1059-0940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zachary A. Cooper","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1059-0940","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043655203","display_name":"Niall J. Dickinson","orcid":"https://orcid.org/0000-0001-6903-0425","observed_orcids":["https://orcid.org/0000-0001-6903-0425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niall J. Dickinson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6903-0425","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044830291","display_name":"Luke A. Masterson","orcid":"https://orcid.org/0000-0002-5366-4025","observed_orcids":["https://orcid.org/0000-0002-5366-4025"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke Masterson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5366-4025","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058444974","display_name":"Thais Cailleau","orcid":"https://orcid.org/0000-0003-0428-1340","observed_orcids":["https://orcid.org/0000-0003-0428-1340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thais Cailleau","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0428-1340","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000709034","display_name":"Ian Hutchinson","orcid":"https://orcid.org/0000-0001-6118-0509","observed_orcids":["https://orcid.org/0000-0001-6118-0509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian Hutchinson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6118-0509","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048240683","display_name":"Balakumar Vijayakrishnan","orcid":"https://orcid.org/0000-0002-0329-8565","observed_orcids":["https://orcid.org/0000-0002-0329-8565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Balakumar Vijayakrishnan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0329-8565","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053107298","display_name":"Mary McFarlane","orcid":"https://orcid.org/0000-0002-1211-8650","observed_orcids":["https://orcid.org/0000-0002-1211-8650"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary McFarlane","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1211-8650","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012679547","display_name":"Kathryn Ball","orcid":"https://orcid.org/0000-0002-5654-8732","observed_orcids":["https://orcid.org/0000-0002-5654-8732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathryn Ball","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5654-8732","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091035527","display_name":"Michael Davies","orcid":"https://orcid.org/0000-0001-9875-2443","observed_orcids":["https://orcid.org/0000-0001-9875-2443"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Davies","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9875-2443","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041289414","display_name":"Arthur R. Lewis","orcid":"https://orcid.org/0000-0002-2496-3819","observed_orcids":["https://orcid.org/0000-0002-2496-3819"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arthur Lewis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2496-3819","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056326026","display_name":"Yue Huang","orcid":"https://orcid.org/0000-0003-2788-0856","observed_orcids":["https://orcid.org/0000-0003-2788-0856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue Huang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2788-0856","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040578796","display_name":"Anton I. Rosenbaum","orcid":"https://orcid.org/0000-0003-1939-951X","observed_orcids":["https://orcid.org/0000-0003-1939-951X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anton I. Rosenbaum","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1939-951X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070406189","display_name":"Jiaqi Yuan","orcid":"https://orcid.org/0000-0003-4575-452X","observed_orcids":["https://orcid.org/0000-0003-4575-452X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiaqi Yuan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4575-452X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050637005","display_name":"Jon Chesebrough","orcid":"https://orcid.org/0000-0003-4885-3611","observed_orcids":["https://orcid.org/0000-0003-4885-3611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon Chesebrough","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4885-3611","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045599189","display_name":"Judith Anderton","orcid":"https://orcid.org/0000-0002-8816-1196","observed_orcids":["https://orcid.org/0000-0002-8816-1196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judith Anderton","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8816-1196","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078346499","display_name":"Noel R. Monks","orcid":"https://orcid.org/0000-0001-6587-9827","observed_orcids":["https://orcid.org/0000-0001-6587-9827"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noel Monks","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6587-9827","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042841642","display_name":"Steven J. Novick","orcid":"https://orcid.org/0000-0001-8760-1519","observed_orcids":["https://orcid.org/0000-0001-8760-1519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Novick","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8760-1519","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052678820","display_name":"Jixin Wang","orcid":"https://orcid.org/0000-0001-7079-2056","observed_orcids":["https://orcid.org/0000-0001-7079-2056"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jixin Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7079-2056","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076501775","display_name":"Nazzareno Dimasi","orcid":"https://orcid.org/0000-0001-9379-1646","observed_orcids":["https://orcid.org/0000-0001-9379-1646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nazzareno Dimasi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9379-1646","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073559624","display_name":"R. James Christie","orcid":"https://orcid.org/0000-0002-8369-804X","observed_orcids":["https://orcid.org/0000-0002-8369-804X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. James Christie","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8369-804X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079106715","display_name":"Darrin Sabol","orcid":"https://orcid.org/0000-0002-9765-9826","observed_orcids":["https://orcid.org/0000-0002-9765-9826"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darrin Sabol","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9765-9826","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014960774","display_name":"Frances Anne Tosto","orcid":"https://orcid.org/0000-0003-1109-7103","observed_orcids":["https://orcid.org/0000-0003-1109-7103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frances Anne Tosto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1109-7103","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085246912","display_name":"Yann Wallez","orcid":"https://orcid.org/0000-0001-9654-6187","observed_orcids":["https://orcid.org/0000-0001-9654-6187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yann Wallez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9654-6187","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008491342","display_name":"Elisabetta Leo","orcid":"https://orcid.org/0000-0002-9761-8637","observed_orcids":["https://orcid.org/0000-0002-9761-8637"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisabetta Leo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9761-8637","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086547100","display_name":"Mark Robert Albertella","orcid":"https://orcid.org/0000-0003-4406-6135","observed_orcids":["https://orcid.org/0000-0003-4406-6135"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark R. Albertella","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4406-6135","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011515348","display_name":"Anna Dominika Staniszewska","orcid":"https://orcid.org/0000-0003-1328-1959","observed_orcids":["https://orcid.org/0000-0003-1328-1959"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna D. Staniszewska","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1328-1959","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019757898","display_name":"David A. Tice","orcid":"https://orcid.org/0000-0001-7819-1351","observed_orcids":["https://orcid.org/0000-0001-7819-1351"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Tice","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7819-1351","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051368970","display_name":"Philip W. Howard","orcid":"https://orcid.org/0000-0001-6392-2289","observed_orcids":["https://orcid.org/0000-0001-6392-2289","https://orcid.org/0000-0001-7828-1154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip W. Howard","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6392-2289","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072096816","display_name":"Nadia Luheshi","orcid":"https://orcid.org/0000-0002-4530-5188","observed_orcids":["https://orcid.org/0000-0002-4530-5188"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadia Luheshi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4530-5188","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014632539","display_name":"Puja Sapra","orcid":"https://orcid.org/0000-0003-0954-2212","observed_orcids":["https://orcid.org/0000-0003-0954-2212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Puja Sapra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0954-2212","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.14159999787807465,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b7-h4","display_name":"B7-H4","score":0.9259999990463257},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9629999995231628},{"id":"https://openalex.org/keywords/topoisomerase-i-inhibitor","display_name":"topoisomerase I inhibitor","score":0.9549999833106995},{"id":"https://openalex.org/keywords/azd5305","display_name":"AZD5305","score":0.9330000281333923},{"id":"https://openalex.org/keywords/parp1-inhibitors","display_name":"PARP-1 inhibitors","score":0.9729999899864197},{"id":"https://openalex.org/keywords/parp-inhibitor-resistance","display_name":"PARP inhibitor resistance","score":0.8659999966621399},{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.9330000281333923},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8119999766349792},{"id":"https://openalex.org/keywords/deep-learning-image-analysis","display_name":"deep learning image analysis","score":0.6470000147819519},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6335253715515137},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.6182169318199158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4854038655757904},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4817495346069336},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4670179486274719},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.38493993878364563},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3842654824256897},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.353962779045105},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3386121392250061},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2171511948108673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21145561337471008},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1746937334537506},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6533087","doi":"https://doi.org/10.1158/1078-0432.c.6533087","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6533087","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6533087","doi":"https://doi.org/10.1158/1078-0432.c.6533087","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6533087","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4308678863","https://openalex.org/W4362595554","https://openalex.org/W4282941445","https://openalex.org/W4281690516","https://openalex.org/W4402560096","https://openalex.org/W4362593017","https://openalex.org/W4409690254","https://openalex.org/W4409690980","https://openalex.org/W3096052300","https://openalex.org/W4210962859"],"abstract_inverted_index":{"AbstractPurpose:":[0],"We":[1],"evaluated":[2],"the":[3,25,214,226],"activity":[4],"of":[5,48,82,101,111,121,128,145,151,178,184,195,205,217,221],"AZD8205,":[6,129],"a":[7,13,66,105,109,143,156],"B7-H4\u2013directed":[8],"antibody\u2013drug":[9],"conjugate":[10],"(ADC)":[11],"bearing":[12],"novel":[14],"topoisomerase":[15],"I":[16],"inhibitor":[17,27],"(TOP1i)":[18],"payload,":[19],"alone":[20],"and":[21,35,45,76,84,94,126,135,175,198,224,241],"in":[22,29,51,71,73,89,180,199],"combination":[23],"with":[24,57,63,138,168],"PARP1-selective":[26],"AZD5305,":[28],"preclinical":[30],"models.":[31,98,182],"Experimental":[32],"Design:":[33],"IHC":[34],"deep-learning\u2013based":[36],"image":[37],"analysis":[38],"algorithms":[39],"were":[40,69,87],"used":[41],"to":[42,162,191],"assess":[43],"prevalence":[44],"intratumoral":[46],"heterogeneity":[47],"B7-H4":[49,113,179],"expression":[50,114],"human":[52,90],"tumors.":[53,117],"Several":[54],"TOP1i-ADCs,":[55],"prepared":[56],"Val-Ala":[58],"or":[59,64],"Gly\u2013Gly\u2013Phe\u2013Gly":[60],"peptide":[61],"linkers,":[62],"without":[65],"PEG8":[67],"spacer,":[68],"compared":[70,137],"biophysical,":[72],"vivo":[74],"efficacy,":[75,134],"rat":[77],"toxicology":[78],"studies.":[79],"AZD8205":[80,154,192,218],"mechanism":[81],"action":[83],"efficacy":[85],"studies":[86],"conducted":[88],"cancer":[91],"cell":[92],"line":[93],"patient-derived":[95],"xenograft":[96],"(PDX)":[97],"Results:":[99],"Evaluation":[100],"IHC-staining":[102],"density":[103],"on":[104],"per-cell":[106],"basis":[107],"revealed":[108],"range":[110],"heterogeneous":[112],"across":[115],"patient":[116],"This":[118],"informed":[119],"selection":[120],"bystander-capable":[122],"Val-Ala\u2013PEG8\u2013TOP1i":[123],"payload":[124],"AZ14170133":[125],"development":[127],"which":[130,166],"demonstrated":[131],"improved":[132],"stability,":[133],"safety":[136],"other":[139],"linker\u2013payload":[140],"ADCs.":[141],"In":[142],"study":[144,234],"26":[146],"PDX":[147],"tumors,":[148],"single":[149],"administration":[150],"3.5":[152],"mg/kg":[153],"provided":[155],"69%":[157],"overall":[158],"response":[159],"rate,":[160],"according":[161],"modified":[163],"RECIST":[164],"criteria,":[165],"correlated":[167],"homologous":[169],"recombination":[170],"repair":[171],"(HRR)":[172],"deficiency":[173],"(HRD)":[174],"elevated":[176],"levels":[177],"HRR-proficient":[181],"Addition":[183],"AZD5305":[185],"sensitized":[186],"very":[187],"low":[188],"B7-H4\u2013expressing":[189,222],"tumors":[190,223],"treatment,":[193],"independent":[194],"HRD":[196],"status":[197],"models":[200],"representing":[201],"clinically":[202],"relevant":[203],"mechanisms":[204],"PARPi":[206],"resistance.":[207],"Conclusions:":[208],"These":[209],"data":[210],"provide":[211],"evidence":[212],"for":[213,219,228],"potential":[215],"utility":[216],"treatment":[220],"support":[225],"rationale":[227],"an":[229],"ongoing":[230],"phase":[231],"1":[232],"clinical":[233],"(NCT05123482).":[235],"See":[236],"related":[237],"commentary":[238],"by":[239],"Pommier":[240],"Thomas,":[242],"p.":[243],"991":[244]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}
