{"id":"https://openalex.org/W4361950448","doi":"https://doi.org/10.1158/1078-0432.c.6520806.v1","title":"Data from Synthetic miR-34a Mimics as a Novel Therapeutic Agent for Multiple Myeloma: In Vitro and In Vivo Evidence","display_name":"Data from Synthetic miR-34a Mimics as a Novel Therapeutic Agent for Multiple Myeloma: In Vitro and In Vivo Evidence","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361950448","doi":"https://doi.org/10.1158/1078-0432.c.6520806.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6520806.v1","doi":"https://doi.org/10.1158/1078-0432.c.6520806.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6520806.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6520806.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031409644","display_name":"Maria Teresa Di Martino","orcid":"https://orcid.org/0000-0002-8205-2706","observed_orcids":["https://orcid.org/0000-0002-8205-2706"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria T. Di Martino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055349907","display_name":"Emanuela Leone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emanuela Leone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077777265","display_name":"Nicola Amodio","orcid":"https://orcid.org/0000-0002-1345-4410","observed_orcids":["https://orcid.org/0000-0002-1345-4410","https://orcid.org/0000-0001-6061-626X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicola Amodio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086577405","display_name":"Umberto Foresta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Umberto Foresta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053958006","display_name":"Marta Lionetti","orcid":"https://orcid.org/0000-0002-3342-9095","observed_orcids":["https://orcid.org/0000-0002-3342-9095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Lionetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060629500","display_name":"Maria Rita Pitari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria R. Pitari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006422655","display_name":"Maria Eugenia Gallo Cantafio","orcid":"https://orcid.org/0009-0009-9937-0565","observed_orcids":["https://orcid.org/0009-0009-9937-0565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria E. Gallo Cantafio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084463088","display_name":"Annamaria Gull\u00e0","orcid":"https://orcid.org/0000-0003-4569-0095","observed_orcids":["https://orcid.org/0000-0003-4569-0095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annamaria Gull\u00e0","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Francesco Conforti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Conforti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018252872","display_name":"Eugenio Morelli","orcid":"https://orcid.org/0000-0002-8850-0442","observed_orcids":["https://orcid.org/0000-0002-8850-0442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugenio Morelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026767610","display_name":"Vera Tomaino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vera Tomaino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Marco Rossi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Rossi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087506952","display_name":"Massimo Negrini","orcid":"https://orcid.org/0000-0002-0007-1920","observed_orcids":["https://orcid.org/0000-0002-0007-1920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimo Negrini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028725821","display_name":"Manlio Ferrarini","orcid":"https://orcid.org/0000-0002-6154-2570","observed_orcids":["https://orcid.org/0000-0002-6154-2570"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manlio Ferrarini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073891277","display_name":"Michele Caraglia","orcid":"https://orcid.org/0000-0003-2408-6091","observed_orcids":["https://orcid.org/0000-0003-2408-6091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michele Caraglia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063099799","display_name":"Masood A. Shammas","orcid":"https://orcid.org/0000-0002-8932-6829","observed_orcids":["https://orcid.org/0000-0002-8932-6829"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masood A. Shammas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045740077","display_name":"Nikhil C. Munshi","orcid":"https://orcid.org/0000-0002-7344-9795","observed_orcids":["https://orcid.org/0000-0002-7344-9795","https://orcid.org/0000-0002-8397-100X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikhil C. Munshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032464400","display_name":"Kenneth Carl Anderson","orcid":"https://orcid.org/0000-0002-6418-0886","observed_orcids":["https://orcid.org/0000-0002-6418-0886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth C. Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042629318","display_name":"Antonino Neri","orcid":"https://orcid.org/0000-0001-9047-5912","observed_orcids":["https://orcid.org/0000-0001-9047-5912"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonino Neri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000930768","display_name":"Pierosandro Tagliaferri","orcid":"https://orcid.org/0000-0002-1535-2477","observed_orcids":["https://orcid.org/0000-0002-1535-2477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierosandro Tagliaferri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077467836","display_name":"Pierfrancesco Tassone","orcid":"https://orcid.org/0000-0002-8298-6787","observed_orcids":["https://orcid.org/0000-0002-8298-6787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierfrancesco Tassone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.4262999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-34a","display_name":"miR-34a","score":0.9800000190734863},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9160000085830688},{"id":"https://openalex.org/keywords/microrna-therapy","display_name":"miRNA-based therapy","score":0.703000009059906},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.8019999861717224},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cdk6","display_name":"CDK6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":1.0},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.6700000166893005},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.7850000262260437},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7619644403457642},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6647129058837891},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49782896041870117},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48196813464164734},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47618380188941956},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4510587155818939},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4137618839740753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2732979655265808},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16049626469612122},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12764710187911987},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6520806.v1","doi":"https://doi.org/10.1158/1078-0432.c.6520806.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6520806.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6520806.v1","doi":"https://doi.org/10.1158/1078-0432.c.6520806.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6520806.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2115397405","https://openalex.org/W2549056926","https://openalex.org/W2027510395","https://openalex.org/W7095422123","https://openalex.org/W2772713217","https://openalex.org/W2575104380","https://openalex.org/W1565226021","https://openalex.org/W6890364082","https://openalex.org/W2144897176","https://openalex.org/W2972714976"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Deregulated":[2],"expression":[3,31,66,75,109],"of":[4,32,51,67,123,188,213],"miRNAs":[5,33],"has":[6,201],"been":[7],"shown":[8,128],"in":[9,58,61,81,84,114,129,131,175,185,204,217],"multiple":[10],"myeloma":[11],"(MM).":[12],"A":[13],"promising":[14],"strategy":[15],"to":[16,28],"achieve":[17],"a":[18,195,209],"therapeutic":[19,49,202],"effect":[20],"by":[21],"targeting":[22],"the":[23,30,48,97,186],"miRNA":[24],"regulatory":[25],"network":[26],"is":[27],"enforce":[29],"that":[34,197],"act":[35],"as":[36,41],"tumor":[37,167],"suppressor":[38],"genes,":[39],"such":[40],"miR-34a.":[42],"Experimental":[43],"Design:":[44],"Here,":[45],"we":[46],"investigated":[47],"potential":[50],"synthetic":[52,69,149,199],"miR-34a":[53,68,87,108,125,183,200],"against":[54],"human":[55,154,163],"MM":[56,82,104,141,164,179,218],"cells":[57,83,158],"vitro":[59],"and":[60,79,93,99,143,159,170,207],"vivo.":[62],"Results:":[63],"Either":[64],"transient":[65],"mimics":[70,184],"or":[71],"lentivirus-based":[72],"miR-34a-stable":[73],"enforced":[74],"triggered":[76],"growth":[77,112,168],"inhibition":[78,113,169],"apoptosis":[80],"vitro.":[85],"Synthetic":[86],"downregulated":[88],"canonic":[89],"targets":[90],"BCL2,":[91],"CDK6,":[92],"NOTCH1":[94],"at":[95],"both":[96],"mRNA":[98],"protein":[100],"level.":[101],"Lentiviral":[102],"vector-transduced":[103],"xenografts":[105,180],"with":[106,148,153,162,182],"constitutive":[107],"showed":[110],"high":[111],"severe":[115],"combined":[116],"immunodeficient":[117],"(SCID)":[118],"mice.":[119],"The":[120],"anti-MM":[121],"activity":[122,203],"lipidic-formulated":[124],"was":[126],"further":[127],"vivo":[130],"two":[132],"different":[133],"experimental":[134],"settings:":[135],"(i)":[136],"SCID":[137],"mice":[138,146,176],"bearing":[139,177],"nontransduced":[140],"xenografts;":[142],"(ii)":[144],"SCID-synth-hu":[145],"implanted":[147],"3-dimensional":[150],"scaffolds":[151],"reconstituted":[152],"bone":[155],"marrow":[156],"stromal":[157],"then":[160],"engrafted":[161],"cells.":[165],"Relevant":[166],"survival":[171],"improvement":[172],"were":[173],"observed":[174],"TP53-mutated":[178],"treated":[181],"absence":[187],"systemic":[189],"toxicity.":[190],"Conclusions:":[191],"Our":[192],"findings":[193],"provide":[194],"proof-of-principle":[196],"formulated":[198],"preclinical":[205],"models":[206],"support":[208],"framework":[210],"for":[211],"development":[212],"miR-34a\u2013based":[214],"treatment":[215],"strategies":[216],"patients.":[219],"Clin":[220],"Cancer":[221],"Res;":[222],"18(22);":[223],"6260\u201370.":[224],"\u00a92012":[225],"AACR.":[226]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-05T00:00:00"}
