{"id":"https://openalex.org/W4361950388","doi":"https://doi.org/10.1158/1078-0432.c.6521042","title":"Data from Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel","display_name":"Data from Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361950388","doi":"https://doi.org/10.1158/1078-0432.c.6521042"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6521042","doi":"https://doi.org/10.1158/1078-0432.c.6521042","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6521042","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6521042","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079008049","display_name":"Anne\u2010Joy M. de Graan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne-Joy M. de Graan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023250449","display_name":"Cynthia S. Lancaster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cynthia S. Lancaster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035777518","display_name":"Amanda Obaidat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Obaidat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073680043","display_name":"Bruno Hagenbuch","orcid":"https://orcid.org/0000-0002-2938-8630","observed_orcids":["https://orcid.org/0000-0002-2938-8630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Hagenbuch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057687580","display_name":"Laure Elens","orcid":"https://orcid.org/0000-0002-0039-3583","observed_orcids":["https://orcid.org/0000-0002-0039-3583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laure Elens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074482150","display_name":"Lena E. Friberg","orcid":"https://orcid.org/0000-0002-2979-679X","observed_orcids":["https://orcid.org/0000-0002-2979-679X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lena E. Friberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047240860","display_name":"Peter de Bruijn","orcid":"https://orcid.org/0000-0003-3372-5756","observed_orcids":["https://orcid.org/0000-0003-3372-5756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter de Bruijn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077955893","display_name":"Shuiying Hu","orcid":"https://orcid.org/0000-0002-9806-7734","observed_orcids":["https://orcid.org/0000-0002-9806-7734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuiying Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Alice A. Gibson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alice A. Gibson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103445067","display_name":"Gitte Hoffmann Bruun","orcid":"https://orcid.org/0000-0002-9127-4749","observed_orcids":["https://orcid.org/0000-0002-9127-4749"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gitte H. Bruun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064608729","display_name":"Thomas J. Corydon","orcid":"https://orcid.org/0000-0003-3588-6350","observed_orcids":["https://orcid.org/0000-0003-3588-6350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J. Corydon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033326521","display_name":"Torben Stamm Mikkelsen","orcid":"https://orcid.org/0000-0001-8188-2188","observed_orcids":["https://orcid.org/0000-0001-8188-2188"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Torben S. Mikkelsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027131917","display_name":"Aisha L. Walker","orcid":"https://orcid.org/0000-0001-8604-6162","observed_orcids":["https://orcid.org/0000-0001-8604-6162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aisha L. Walker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077821599","display_name":"Guoqing Du","orcid":"https://orcid.org/0000-0001-7963-4652","observed_orcids":["https://orcid.org/0000-0001-7963-4652"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guoqing Du","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113691409","display_name":"Walter J. Loos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter J. Loos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112254985","display_name":"Ron H. N. van Schaik","orcid":"https://orcid.org/0000-0003-1864-2151","observed_orcids":["https://orcid.org/0000-0003-1864-2151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ron H. N. van Schaik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077260725","display_name":"Sharyn D. Baker","orcid":"https://orcid.org/0000-0003-3062-3252","observed_orcids":["https://orcid.org/0000-0003-3062-3252"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharyn D. Baker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074174053","display_name":"Ron H.J. Mathijssen","orcid":"https://orcid.org/0000-0001-5667-5697","observed_orcids":["https://orcid.org/0000-0001-5667-5697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ron H. J. Mathijssen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065279964","display_name":"Alex Sparreboom","orcid":"https://orcid.org/0000-0003-2660-6644","observed_orcids":["https://orcid.org/0000-0003-2660-6644"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Sparreboom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1842000037431717,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oatp1b1","display_name":"OATP1B1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oatp1b3","display_name":"OATP1B3","score":1.0},{"id":"https://openalex.org/keywords/oatp1b2","display_name":"Oatp1b2","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hepatic-drug-uptake","display_name":"hepatic drug uptake","score":0.7839999794960022},{"id":"https://openalex.org/keywords/drug-disposition","display_name":"drug disposition","score":0.5460000038146973},{"id":"https://openalex.org/keywords/cyp3a4-metabolism","display_name":"CYP3A4 metabolism","score":0.7369999885559082},{"id":"https://openalex.org/keywords/rs4149056","display_name":"rs4149056","score":0.8999999761581421},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.6549999713897705},{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.9025458693504333},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5605352520942688},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5564244985580444},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5516862273216248},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.5095984935760498},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45546066761016846},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4292046129703522},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4121074974536896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27219343185424805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26465466618537903},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18908461928367615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17029067873954773},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08760929107666016},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.08646520972251892}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.c.6521042","doi":"https://doi.org/10.1158/1078-0432.c.6521042","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6521042","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6521042.v1","doi":"https://doi.org/10.1158/1078-0432.c.6521042.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6521042.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6521042","doi":"https://doi.org/10.1158/1078-0432.c.6521042","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6521042","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2095993519","https://openalex.org/W7075601769","https://openalex.org/W1961223560","https://openalex.org/W4362495464","https://openalex.org/W2146553113","https://openalex.org/W1550577419","https://openalex.org/W2327071570","https://openalex.org/W2045111884","https://openalex.org/W2000478673","https://openalex.org/W4392679743"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Docetaxel":[2,84,110],"is":[3,17,33,234],"extensively":[4],"metabolized":[5],"by":[6,13,35,126],"CYP3A4":[7],"in":[8,48,63,88,96,131,139,150,154,169,192,207],"the":[9,15,36,80,163,193,202,224],"liver":[10,29,156,195],"but":[11,122],"mechanisms":[12],"which":[14,145],"drug":[16,54],"taken":[18],"up":[19],"into":[20],"hepatocytes":[21],"remain":[22],"poorly":[23],"understood.":[24],"We":[25],"hypothesized":[26],"that":[27,204,232,245],"(i)":[28],"uptake":[30,190],"of":[31,59,99,129,162,184,209,223],"docetaxel":[32,60,140,176,200,237],"mediated":[34],"polymorphic":[37],"solute":[38],"carriers":[39],"OATP1B1":[40,170,249],"and":[41,43,90,120,250],"OATP1B3":[42,172],"(ii)":[44],"inherited":[45],"genetic":[46],"defects":[47,206],"this":[49],"process":[50],"may":[51,212],"impair":[52],"systemic":[53],"elimination.":[55],"Experimental":[56],"Design:":[57],"Transport":[58],"was":[61,86,111,123,133,146],"studied":[62,164],"vitro":[64],"using":[65],"various":[66],"cell":[67],"lines":[68],"stably":[69],"transfected":[70],"with":[71,101,135,175,196,243],"OATP1B1*1A":[72],"(wild-type),":[73],"OATP1B1*5":[74],"[c.521T>C":[75],"(V174A);":[76],"rs4149056],":[77],"OATP1B3,":[78,119],"or":[79,171],"mouse":[81,155],"transporter":[82,104],"Oatp1b2.":[83],"clearance":[85,141,177],"evaluated":[87],"wild-type":[89],"Oatp1b2-knockout":[91],"mice":[92,132],"as":[93,95],"well":[94],"two":[97,187],"cohorts":[98],"patients":[100],"multiple":[102],"variant":[103],"genotypes":[105],"(n":[106],"=":[107,143],"213).":[108],"Results:":[109],"found":[112],"to":[113,148,215,239],"be":[114,213,240],"a":[115],"substrate":[116],"for":[117,199,228],"OATP1B1,":[118],"Oatp1b2":[121,130],"not":[124],"transported":[125],"OATP1B1*5.":[127],"Deficiency":[128],"associated":[134,174],"an":[136],"18-fold":[137],"decrease":[138],"(P":[142,178],"0.0099),":[144],"unrelated":[147],"changes":[149],"intrinsic":[151],"metabolic":[152],"capacity":[153],"microsomes.":[157],"In":[158,221],"patients,":[159],"however,":[160],"none":[161],"common":[165],"reduced":[166],"function":[167],"variants":[168],"were":[173],">":[179],"0.05).":[180],"Conclusions:":[181],"The":[182],"existence":[183],"at":[185],"least":[186],"potentially":[188],"redundant":[189],"transporters":[191],"human":[194],"similar":[197],"affinity":[198],"supports":[201],"possibility":[203],"functional":[205],"both":[208,248],"these":[210],"proteins":[211],"required":[214],"confer":[216],"substantially":[217],"altered":[218],"disposition":[219],"phenotypes.":[220],"view":[222],"established":[225],"exposure\u2013toxicity":[226],"relationships":[227],"docetaxel,":[229],"we":[230],"suggest":[231],"caution":[233],"warranted":[235],"if":[236],"has":[238],"administered":[241],"together":[242],"agents":[244],"potently":[246],"inhibit":[247],"OATP1B3.":[251],"Clin":[252],"Cancer":[253],"Res;":[254],"18(16);":[255],"4433\u201340.":[256],"\u00a92012":[257],"AACR.":[258]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
